γ-Carboxyglutamic acids 36 and 40 do not contribute to human factor IX function

Autor: H. Patel, B. C. Furie, H. A. Scoble, M. C. Huberty, B. Furie, M Bond, S. Gillis, W. B. Foster, M. Switzer

Publikováno v: Protein Science. 6:185-196

The gamma-carboxyglutamic acid (Gla) domains of the vitamin K-dependent blood coagulation proteins contain 10 highly conserved Gla residues within the first 33 residues, but factor IX is unique in possessing 2 additional Gla residues at positions 36

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c6596f485bea983fb49b24493b394ef
https://doi.org/10.1002/pro.5560060121

Surreptitious ingestion of a long-acting vitamin K antagonist/rodenticide, brodifacoum: clinical and metabolic studies of three cases

Autor: J N, Weitzel, J A, Sadowski, B C, Furie, R, Moroose, H, Kim, M E, Mount, M J, Murphy, B, Furie

Publikováno v: Blood. 76:2555-2559

The vitamin K metabolism of three patients with factitious purpura due to brodifacoum ingestion was studied. These patients, who presented with bleeding disorders due to deficiency of the vitamin K-dependent blood clotting proteins, were refractory t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::756d11812b728d0eb58019afa3dcf928
https://doi.org/10.1182/blood.v76.12.2555.bloodjournal76122555

Mechanochemistry: Fundamental Principles and Applications.

Autor: Dong L; Collaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Department of Physics, Nanjing University, Nanjing, Jiangsu, 210093, P. R. China., Li L; Collaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Department of Physics, Nanjing University, Nanjing, Jiangsu, 210093, P. R. China., Chen H; Collaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Department of Physics, Nanjing University, Nanjing, Jiangsu, 210093, P. R. China., Cao Y; Collaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Department of Physics, Nanjing University, Nanjing, Jiangsu, 210093, P. R. China., Lei H; School of Physics, Zhejiang University, Hangzhou, Zhejiang, 310027, P. R. China.; Institute of Advanced Physics, Zhejiang University, Hangzhou, Zhejiang, 310027, P. R. China.

Publikováno v: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Aug 29, pp. e2403949. Date of Electronic Publication: 2024 Aug 29.

Alpha-granule secretion from alpha-toxin permeabilized, MgATP-exposed platelets is induced independently by H+ and Ca2+

Autor: R, Flaumenhaft, B, Furie, B C, Furie

Publikováno v: Journal of cellular physiology. 179(1)

In order to better understand granule release from platelets, we developed an alpha-toxin permeabilized platelet model to study alpha-granule secretion. Secretion of alpha-granules was analyzed by flow cytometry using P-selectin as a marker for alpha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::926c85574f33ec5ae1c09218b0a760be
https://pubmed.ncbi.nlm.nih.gov/10082126

Proteins of the exocytotic core complex mediate platelet alpha-granule secretion. Roles of vesicle-associated membrane protein, SNAP-23, and syntaxin 4

Autor: R, Flaumenhaft, K, Croce, E, Chen, B, Furie, B C, Furie

Publikováno v: The Journal of biological chemistry. 274(4)

To understand the molecular basis of granule release from platelets, we examined the role of vesicle-associated membrane protein, SNAP-23, and syntaxin 4 in alpha-granule secretion. A vesicle-associated membrane protein, SNAP-23, and syntaxin 4 were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::21801a6cfafa9946c2cf6953738dbf11
https://pubmed.ncbi.nlm.nih.gov/9891020