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Developmental toxicity of 4-substituted amphetamines in mice

Autor: Harpal S. Buttar, B. C. Foster, James H Moffatt

Publikováno v: Reproductive Toxicology. 10:301-310

Despite overwhelming and tragic evidence of their detrimental and dangerous consequences, amphetamines remain significant drugs of abuse and addiction. The effects of 4-substituted amphetamines: 4-hydroxyamphetamine (4-HA), 4-methoxyamphetamine (4-ME

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d2422d1fef6206ce40f38d9edd1b8af
https://doi.org/10.1016/0890-6238(96)00059-7

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Effects of feeding diets containing Fusarium (naturally) contaminated wheat or pure deoxynivalenol (DON) in growing pigs

Autor: K. E. Hartin, H. L. Trenholm, R. W. Coppock, L. L. Charmley, M. A. Albassam, B. K. Thompson, B. C. Foster

Publikováno v: Canadian Journal of Animal Science. 74:361-369

Three experiments were conducted to determine the effects of feeding diets containing laboratory synthesized deoxynivalenol (DON), or Fusarium (naturally) contaminated wheat containing DON on performance and health of young pigs (32.8–41.1 kg body

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4e14857870a8d16f71b797e92b4081ca
https://doi.org/10.4141/cjas94-049

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Microbial transformation of 3,4-methylenedioxy-N-methylamphetamine and 3,4-methylenedioxyamphetamine

Autor: T. Marwood, D. L. Wilson, Jiri Zamecnik, B. C. Foster, J. C. Ethier

Publikováno v: Canadian journal of microbiology. 42(8)

The biotransformation of 3,4-methylenedioxy-N-methylarnphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA) was examined in the fungus Cunninghamella echinulata. In addition to the reported mammalian metabolites (MDA, 3,4-methylenedioxybenzyl met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::078126bb1e93d356815e8f4a66359fc4
https://pubmed.ncbi.nlm.nih.gov/22049999

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Biotransformation of tri-substituted methoxyamphetamines by Cunninghamella echinulata

Autor: B. A. Lodge, Jiri Zamecnik, D. L. Wilson, B. C. Foster, J. McLeish, L. W. Whitehouse

Publikováno v: Xenobiotica. 22:1383-1394

1. Four trimethoxyamphetamine analogues were incubated with the filamentous fungus Cunninghamella echinulata. 2. 2,4,5-Trimethoxyamphetamine and 2,5-dimethoxy-4-ethoxyamphetamine were poorly metabolized by C. echinulata ATCC 9244 and C. echinulata va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc14eaa33a9da95aadfdd836619fc223
https://doi.org/10.3109/00498259209056689

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In vitro assessment of cytotoxicity and biotransformation of propranolol in Cunninghamella echinulata

Autor: E. Ormsby, B. C. Foster, D. L. Wilson, B. A. Dawson, D. L. Litster

Publikováno v: Xenobiotica. 22:1221-1228

1. Biotransformation studies with five concentrations of racemic propranolol were conducted using the filamentous fungus Cunninghamella echinulata ATCC 9244. 2. The rate of formation and subsequent disappearance of a new major metabolite, 8-hydroxypr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb9aadf9e4ce002f9396b1c3bd82ece
https://doi.org/10.3109/00498259209053150

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Aromatic hydroxylation and sulfation of phenazopyridine by Cunninghamella echinulata

Autor: G. Solomonraj, Jiri Zamecnik, Bruce A. Lodge, B. C. Foster, Randy Duhaime, Brian A. Dawson, Barry H. Thomas, D. Lynden Wilson, Iain J. McGilveray

Publikováno v: Canadian Journal of Microbiology. 37:504-508

The metabolism of phenazopyridine was studied in the filamentous fungus Cunninghamella echinulata (synonym C. bainieri) ATCC 9244. Metabolic products were initially isolated by HPLC and TLC, with further characterization achieved by a combination of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c50cfe9ce41a0d6dc6b0c8a5b707ccc
https://doi.org/10.1139/m91-085

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Biotransformation of 2-, 3-, and 4-methoxy-amphetamines byCunninghamella echinulata

Autor: D. L. Litster, B. C. Foster, B. A. Lodge

Publikováno v: Xenobiotica. 21:1337-1346

1. Three methoxyamphetamine analogues have been incubated with Cunninghamella echinulata under different environmental and nutrient conditions. 2. The biotransformation of 4-methoxyamphetamine was inhibited by cobalt; the carbon source and other trac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1efaf190bf843ff7938aadd32aa2651b
https://doi.org/10.3109/00498259109043208

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Dextran sulfate disposition in the rat

Autor: B. C. Foster, Keith Gallicano, I. J. McGilveray, Saifur R. Khan, L. W. Whitehouse

Publikováno v: Biopharmaceutics & Drug Disposition. 11:595-606

Comparative studies of oral and intravenous administration of tritiated dextran sulfate in rats showed markedly different distribution patterns. Following IV dosing about 50 per cent of the radioactivity was recovered in feces and urine within 24 h.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbee9c94ffc55517578efcc753a9b791
https://doi.org/10.1002/bdd.2510110705

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Fungal metabolism of 4-substituted amphetamines

Autor: A. W. By, B. A. Lodge, D. L. Wilson, B. C. Foster, L. M. Nantais, Jiri Zamecnik

Publikováno v: Xenobiotica. 20:583-590

1. rac.-4-Ethoxyamphetamine was incubated with 14 different yeast and fungal microorganisms. 4-Hydroxyamphetamine was the major metabolite; traces of N-acetyl-4-ethoxyamphetamine were also detected. 2. The major fungal (Cunninghamella) metabolite of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::186d1581e157e5f12a3c23abd628ed90
https://doi.org/10.3109/00498259009046873

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