Výsledky vyhledávání - "B C, Broughton"

Trichothiodystrophy, a human DNA repair disorder with heterogeneity in the cellular response to ultraviolet light

Autor: A R, Lehmann, C F, Arlett, B C, Broughton, S A, Harcourt, H, Steingrimsdottir, M, Stefanini, A, Malcolm, R, Taylor, A T, Natarajan, S, Green

Publikováno v: Cancer research. 48(21)

Trichothiodystrophy (TTD) is an autosomal recessive disorder characterized by brittle hair with reduced sulfur content, ichthyosis, peculiar face, and mental and physical retardation. Some patients are photosensitive. A previous study by Stefanini et

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::35bedf3a1a585ec5c597ec3d623a7dcb
https://pubmed.ncbi.nlm.nih.gov/2458832

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A biochemical defect in the repair of alkylated DNA in cells from an immunodeficient patient (46BR)

Autor: P Karran, I A Teo, R S Day, Alan R. Lehmann, M.R. James, L V Mayne, B C Broughton

Publikováno v: Carcinogenesis. 4(5)

The fibroblast cell strain 46BR, derived from an immunodeficient individual, is hypersensitive to the lethal effects of a variety of DNA-damaging agents, this effect being particularly marked for monofunctional methylating agents. After U.V. irradiat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8102128aa5583a1ca40d1edf928fb165
https://pubmed.ncbi.nlm.nih.gov/6850987

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The ultraviolet sensitivity of Cockayne syndrome cells is not a consequence of reduced cellular NAD content

Autor: L V, Mayne, B C, Broughton, A R, Lehmann

Publikováno v: American journal of human genetics. 36(2)

Cells from individuals with Cockayne syndrome (CS) are hypersensitive to the lethal effects of ultraviolet light (uv) and show a number of abnormal biochemical responses following uv-irradiation. Fujiwara et al. recently reported that the NAD content

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0bad64cf58431c947e3c236405327a77
https://pubmed.ncbi.nlm.nih.gov/6201064

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Poly(ADP-ribosylation) reduces the steady-state level of breaks in DNA following treatment of human cells with alkylating agents

Autor: B. C. Broughton, Alan R. Lehmann

Publikováno v: Carcinogenesis. 5(1)

Following treatment of human fibroblasts with dimethyl-sulphate, more breaks persisted in DNA in cells incubated with 3-aminobenzamide, an inhibitor of ADP-ribosyltransferase, than in its absence. This effect of 3-aminobenzamide was more pronounced i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789db81a862c13c345c94d176b73396b
https://pubmed.ncbi.nlm.nih.gov/6317222

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