Zobrazeno 1 - 10
of 666
pro vyhledávání: '"B Brett Finlay"'
Autor:
Sarah E Woodward, Laurel M P Neufeld, Jorge Peña-Díaz, Wenny Feng, Antonio Serapio-Palacios, Isabel Tarrant, Wanyin Deng, B Brett Finlay
Publikováno v:
PLoS Biology, Vol 22, Iss 8, p e3002761 (2024)
Enteric pathogens navigate distinct regional microenvironments within the intestine that cue important adaptive behaviors. We investigated the response of Citrobacter rodentium, a model of human pathogenic Escherichia coli infection in mice, to regio
Externí odkaz:
https://doaj.org/article/bf39aca966254f04bdd241b67abf2f66
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 9, Pp 1-12 (2019)
Abstract All species, including humans, are cohabited by a myriad of microbial species, which massively influences body function in a diet‐, exercise‐ and age‐dependent manner. The microbiome composition differs between individuals, partly due
Externí odkaz:
https://doaj.org/article/de2371aaa0f741d3aaa87f055c492552
Autor:
Rozlyn CT Boutin, Charisse Petersen, Sarah E Woodward, Antonio Serapio-Palacios, Tahereh Bozorgmehr, Rachelle Loo, Alina Chalanuchpong, Mihai Cirstea, Bernard Lo, Kelsey E Huus, Weronika Barcik, Meghan B Azad, Allan B Becker, Piush J Mandhane, Theo J Moraes, Malcolm R Sears, Padmaja Subbarao, Kelly M McNagny, Stuart E Turvey, B Brett Finlay
Publikováno v:
eLife, Vol 10 (2021)
Bacterial members of the infant gut microbiota and bacterial-derived short-chain fatty acids (SCFAs) have been shown to be protective against childhood asthma, but a role for the fungal microbiota in asthma etiology remains poorly defined. We recentl
Externí odkaz:
https://doaj.org/article/3528669980c6489896b4811b6c6f4526
Autor:
Katelyn Knuff-Janzen, Audrey Tupin, Sophie Yurist-Doutsch, Jennifer L Rowland, B Brett Finlay
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0235020 (2020)
The pathogenesis of Salmonella Typhimurium depends on the bacterium's ability to survive and replicate within host cells. The formation and maintenance of a unique membrane-bound compartment, termed the Salmonella-containing vacuole (SCV), is essenti
Externí odkaz:
https://doaj.org/article/a6221295ad9d40099d923a2d7faf88b7
Autor:
Jérôme Tourret, Benjamin P Willing, Matthew A Croxen, Nicolas Dufour, Sara Dion, Sarah Wachtel, Erick Denamur, B Brett Finlay
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153034 (2016)
Uropathogenic Escherichia coli (UPEC) strains live as commensals in the digestive tract of the host, but they can also initiate urinary tract infections. The aim of this work was to determine how a host detects the presence of a new UPEC strain in th
Externí odkaz:
https://doaj.org/article/dbb0ff792dd94c9a9395f462f78a7034
Autor:
Sophie Yurist-Doutsch, Marie-Claire Arrieta, Audrey Tupin, Yanet Valdez, L Caetano M Antunes, Ryan Yen, B Brett Finlay
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159676 (2016)
Salmonella enterica serovar Typhimurium (S. Typhimurium) is a foodborne enteric pathogen and a major cause of gastroenteritis in humans. It is known that molecules derived from the human fecal microbiota downregulate S. Typhimurium virulence gene exp
Externí odkaz:
https://doaj.org/article/d94aaa3e20064e97bc38d26bb1f83f76
Autor:
Matthew K Waldor, Gene Tyson, Elhanan Borenstein, Howard Ochman, Andrew Moeller, B Brett Finlay, Heidi H Kong, Jeffrey I Gordon, Karen E Nelson, Karim Dabbagh, Hamilton Smith
Publikováno v:
PLoS Biology, Vol 13, Iss 1, p e1002050 (2015)
The development of high-throughput sequencing technologies has transformed our capacity to investigate the composition and dynamics of the microbial communities that populate diverse habitats. Over the past decade, these advances have yielded an aval
Externí odkaz:
https://doaj.org/article/6457b55f90cd4e3ca038da5b4026adf6
Autor:
Ricarda Cortés-Vieyra, Octavio Silva-García, Javier Oviedo-Boyso, Alejandro Huante-Mendoza, Alejandro Bravo-Patiño, Juan J Valdez-Alarcón, B Brett Finlay, Víctor M Baizabal-Aguirre
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132867 (2015)
Glycogen synthase kinase 3 (GSK3) is a constitutively active regulatory enzyme that is important in cancer, diabetes, and cardiovascular, neurodegenerative, and psychiatric diseases. While GSK3α is usually important in neurodegenerative and psychiat
Externí odkaz:
https://doaj.org/article/889ef8d428084158ac438db8aab2b60b
Publikováno v:
Canadian Journal of Gastroenterology, Vol 16, Iss 11, Pp 771-778 (2002)
Enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E coli (EHEC) are important causes of infectious diarrhea, particularly among pediatric populations. While EPEC is a significant health threat in the developing world, EHEC causes sporadi
Externí odkaz:
https://doaj.org/article/6ce905da832d4d368f5f4664088fb575
Autor:
Amit P Bhavsar, Nat F Brown, Jan Stoepel, Marcel Wiermer, Dale D O Martin, Karolynn J Hsu, Koshi Imami, Colin J Ross, Michael R Hayden, Leonard J Foster, Xin Li, Phil Hieter, B Brett Finlay
Publikováno v:
PLoS Pathogens, Vol 9, Iss 7, p e1003518 (2013)
To further its pathogenesis, S. Typhimurium delivers effector proteins into host cells, including the novel E3 ubiquitin ligase (NEL) effector SspH2. Using model systems in a cross-kingdom approach we gained further insight into the molecular functio
Externí odkaz:
https://doaj.org/article/18d8300ef9bc4b3f815eb0cf4287600f