Zobrazeno 1 - 10
of 590
pro vyhledávání: '"B Blomberg"'
Autor:
Sonal V. Gidwani, Devarshi Brahmbhatt, Aaron Zomback, Mamie Bassie, Jennifer Martinez, Jian Zhuang, John Schulze, Jason S. McLellan, Roberto Mariani, Peter Alff, Daniela Frasca, Bonnie B. Blomberg, Christopher P. Marshall, Mark A. Yondola
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Viral fusion proteins facilitate cellular infection by fusing viral and cellular membranes, which involves dramatic transitions from their pre- to postfusion conformations. These proteins are among the most protective viral immunogens, but t
Externí odkaz:
https://doaj.org/article/9f64bc085d664e7cb563be6d97f3ebf8
Publikováno v:
Immunity & Ageing, Vol 20, Iss 1, Pp 1-11 (2023)
Abstract Background We have previously shown that obesity accelerates age-associated defects in B cell function and antibody production leading to decreased secretion of protective antibodies and increased autoimmunity. We wanted to evaluate if obese
Externí odkaz:
https://doaj.org/article/535ee2b334544355925dfb97d393bccb
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0285025 (2023)
In this study, we have compared frequencies, phenotype, function and metabolic requirements of B cells isolated from the breast and abdominal subcutaneous adipose tissue (AT) of women with obesity who underwent weight reduction surgeries. Results sho
Externí odkaz:
https://doaj.org/article/00884dadd0444357a3c2b9af24b63931
Publikováno v:
Immunity & Ageing, Vol 18, Iss 1, Pp 1-11 (2021)
Abstract Background Aging is associated with increased intrinsic B cell inflammation, decreased protective antibody responses and increased autoimmune antibody responses. The effects of aging on the metabolic phenotype of B cells and on the metabolic
Externí odkaz:
https://doaj.org/article/2177035512f943bba2ed69dd2130cd69
Aging induces B cell defects and decreased antibody responses to influenza infection and vaccination
Autor:
Daniela Frasca, Bonnie B. Blomberg
Publikováno v:
Immunity & Ageing, Vol 17, Iss 1, Pp 1-10 (2020)
Abstract Background Aging is characterized by a progressive decline in the capacity of the immune system to fight influenza virus infection and to respond to vaccination. Among the several factors involved, in addition to increased frailty and high-r
Externí odkaz:
https://doaj.org/article/494261780ecf4eaaac1d89bd1be952f0
Publikováno v:
Frontiers in Aging, Vol 2 (2022)
We have measured the secretion of autoimmune antibodies in plasma samples and in culture supernatants of blood-derived B cells from four groups of individuals: young lean (YL), elderly lean (EL), young obese (YO) and elderly obese (EO). We found secr
Externí odkaz:
https://doaj.org/article/944f0ce3528a428a96127720d9ac368b
Publikováno v:
Frontiers in Aging, Vol 2 (2021)
Our previous work has shown that young and elderly patients with Type-2 Diabetes Mellitus (T2DM) treated with Metformin have optimal B cell function and serum antibodies specific for the seasonal influenza vaccine. In this paper, we have evaluated B
Externí odkaz:
https://doaj.org/article/827dddde63b641bb82316d121851ecd2
Autor:
Raghuram Reddy, Joel Mintz, Roei Golan, Fakiha Firdaus, Roxana Ponce, Derek Van Booven, Aysswarya Manoharan, Isabelle Issa, Bonnie B. Blomberg, Himanshu Arora
Publikováno v:
Vaccines, Vol 10, Iss 8, p 1165 (2022)
Patients with cancer tend to develop antibodies to autologous proteins. This phenomenon has been observed across multiple cancer types, including bladder, lung, colon, prostate, and melanoma. These antibodies potentially arise due to induced inflamma
Externí odkaz:
https://doaj.org/article/05a7eadfc77b407aac1c91b224ac9bdc
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
We have previously shown that obesity is associated with increased secretion of IgG antibodies with anti-self-reactivity. In this paper, we confirm and extend our previous findings. We show that the plasma of individuals with obesity is enriched in a
Externí odkaz:
https://doaj.org/article/fc0bcf270dc2430dbca57aceb5c811f4
Autor:
Daniela Frasca, Lisa Reidy, Carolyn Cray, Alain Diaz, Maria Romero, Kristin Kahl, Bonnie B Blomberg
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0245424 (2021)
SARS-CoV-2 (Severe Acute Respiratory Syndrome Corona Virus-2), cause of COVID-19 (Coronavirus Disease of 2019), represents a significant risk to people living with pre-existing conditions associated with exacerbated inflammatory responses and consequ
Externí odkaz:
https://doaj.org/article/e3c56a4c19304b4dbb4bd70abc5470d1