Zobrazeno 1 - 10
of 20
pro vyhledávání: '"B Alexander, Yi"'
Autor:
Christopher A Werley, Miao-Ping Chien, Jellert Gaublomme, Karthik Shekhar, Vincent Butty, B Alexander Yi, Joel M Kralj, William Bloxham, Laurie A Boyer, Aviv Regev, Adam E Cohen
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0172671 (2017)
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are a promising platform for cardiac studies in vitro, and possibly for tissue repair in humans. However, hiPSC-CM cells tend to retain morphology, metabolism, patterns of gene exp
Externí odkaz:
https://doaj.org/article/23e59abed85b48d2860c1c438a159503
Publikováno v:
The New England journal of medicine. 385(19)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ffcc2a2137b5198bf94552754f6d36b4
https://pubmed.ncbi.nlm.nih.gov/34731546
https://pubmed.ncbi.nlm.nih.gov/34731546
Autor:
Peter, Verhamme, B Alexander, Yi, Annelise, Segers, Janeen, Salter, Daniel, Bloomfield, Harry R, Büller, Gary E, Raskob, Jeffrey I, Weitz, Chernivtsi Y, Vasylchyshyn
Publikováno v:
New England journal of medicine, 385(7), 609-617. Massachussetts Medical Society
The role of factor XI in the pathogenesis of postoperative venous thromboembolism is uncertain. Abelacimab is a monoclonal antibody that binds to factor XI and locks it in the zymogen (inactive precursor) conformation.In this open-label, parallel-gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d61d26a75ee377b5fef9afe108eafa2c
https://pubmed.ncbi.nlm.nih.gov/34871049
https://pubmed.ncbi.nlm.nih.gov/34871049
Publikováno v:
Clinical Pharmacology and Therapeutics
There remains a large unmet need for new therapies in the treatment of heart failure with reduced ejection fraction (HFrEF). In the early drug development phase, the therapeutic potential of a drug is not yet fully understood and trial endpoints othe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2c36b4c87389e30bcff78b2c11e1230
https://doi.org/10.1002/cpt.1010
https://doi.org/10.1002/cpt.1010
Autor:
Aviv Regev, Vincent L. Butty, B. Alexander Yi, Miao-Ping Chien, Karthik Shekhar, Christopher A. Werley, Laurie A. Boyer, Jellert Gaublomme, Joel M. Kralj, William Bloxham, Adam E. Cohen
Publikováno v:
PLoS
PLoS ONE
PloS one, vol 12, iss 3
PLoS ONE, Vol 12, Iss 3, p e0172671 (2017)
PLoS ONE
PloS one, vol 12, iss 3
PLoS ONE, Vol 12, Iss 3, p e0172671 (2017)
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are a promising platform for cardiac studies in vitro, and possibly for tissue repair in humans. However, hiPSC-CM cells tend to retain morphology, metabolism, patterns of gene exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daf9bf623fdd95bd5daa67ceed2002d9
https://orcid.org/0000-0001-8567-2049
https://orcid.org/0000-0001-8567-2049
Autor:
Hongcang Gu, Alexander Meissner, Joo Hye C. Park, Ying Shao, Erding Hu, John J. Lepore, Kenneth R. Chien, Hao Wu, Alyssa K. Riley, Zhong Wang, Robert N. Willette, Ibrahim J. Domian, Kathy O. Lui, Huansheng Xu, B. Alexander Yi, Christoph Bock
Publikováno v:
Cell Research. 22:142-154
Cardiomyocytes derived from pluripotent stem cells can be applied in drug testing, disease modeling and cell-based therapy. However, without procardiogenic growth factors, the efficiency of cardiomyogenesis from pluripotent stem cells is usually low
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f876e80451e242b3a49a190bb014e31
https://doi.org/10.1038/cr.2011.171
https://doi.org/10.1038/cr.2011.171
Publikováno v:
Journal of Clinical Investigation. 120:20-28
The ability to create new functional cardiomyocytes is the holy grail of cardiac regenerative medicine. From studies using model organisms, new insights into the fundamental pathways that drive heart muscle regeneration have begun to arise as well as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d94ea2e77b26208937efe101335264ec
https://doi.org/10.1172/jci40820
https://doi.org/10.1172/jci40820
Publikováno v:
Journal of Molecular and Cellular Cardiology, 53(3), 311-313
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad5b0c0909cc2dc62be490a6a7845b82
https://doi.org/10.1016/j.yjmcc.2012.06.010
https://doi.org/10.1016/j.yjmcc.2012.06.010
Publikováno v:
Cell Research. 22:1521-1523
The term "lineage reprogramming" is typically used to describe the conversion of one differentiated somatic cell type into another without transit through a pluripotent intermediate. Two recent reports in Nature demonstrate that such a conversion can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5256fb3c8974118943b4bda9c6c5950
https://doi.org/10.1038/cr.2012.101
https://doi.org/10.1038/cr.2012.101
Publikováno v:
Nature Cell Biology. 13:191-193
The adult human heart lacks sufficient regenerative capacity to recover after a myocardial infarction. Cell-based therapy has emerged as a potential treatment for the failing heart; however, a key issue for the success of future cell-based therapies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b8595697478edb3a7b503b811382604
https://doi.org/10.1038/ncb0311-191
https://doi.org/10.1038/ncb0311-191