Zobrazeno 1 - 10
of 115
pro vyhledávání: '"B Alex Merrick"'
Autor:
Deepak Mav, Dhiral P Phadke, Michele R Balik-Meisner, B Alex Merrick, Scott Auerbach, Marije Niemeijer, Suzanna Huppelschoten, Audrey Baze, Celine Parmentier, Lysiane Richert, Bob van de Water, Ruchir R Shah, Richard S Paules
Publikováno v:
Bioinformatics and Biology Insights, Vol 14 (2020)
The TempO-Seq S1500+ platform(s), now available for human, mouse, rat, and zebrafish, measures a discrete number of genes that are representative of biological and pathway co-regulation across the entire genome in a given species. While measurement o
Externí odkaz:
https://doaj.org/article/d6f389cb95e54e188488ba1e4c1a51c4
Autor:
Deepak Mav, Ruchir R Shah, Brian E Howard, Scott S Auerbach, Pierre R Bushel, Jennifer B Collins, David L Gerhold, Richard S Judson, Agnes L Karmaus, Elizabeth A Maull, Donna L Mendrick, B Alex Merrick, Nisha S Sipes, Daniel Svoboda, Richard S Paules
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0191105 (2018)
Changes in gene expression can help reveal the mechanisms of disease processes and the mode of action for toxicities and adverse effects on cellular responses induced by exposures to chemicals, drugs and environment agents. The U.S. Tox21 Federal col
Externí odkaz:
https://doaj.org/article/ac4c3100313c431db2f048cc682fb4c1
Autor:
B Alex Merrick, Justin S Chang, Dhiral P Phadke, Meredith A Bostrom, Ruchir R Shah, Xinguo Wang, Oksana Gordon, Garron M Wright
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190992 (2018)
The transcriptome can reveal insights into precancer biology. We recently conducted RNA-Seq analysis on liver RNA from male rats exposed to the carcinogen, aflatoxin B1 (AFB1), for 90 days prior to liver tumor onset. Among >1,000 differentially expre
Externí odkaz:
https://doaj.org/article/25bd8608d23d4629a3f9705634361845
Autor:
Daniel L Morgan, B Alex Merrick, Kevin E Gerrish, Patricia S Stockton, Yu Wang, Julie F Foley, William M Gwinn, Francine L Kelly, Scott M Palmer, Thai-Vu T Ton, Gordon P Flake
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0118459 (2015)
Obliterative bronchiolitis (OB) is an irreversible lung disease characterized by progressive fibrosis in the small airways with eventual occlusion of the airway lumens. OB is most commonly associated with lung transplant rejection; however, OB has al
Externí odkaz:
https://doaj.org/article/ed935998995a4245ac6ff095d7654c8d
Autor:
B Alex Merrick, Dhiral P Phadke, Scott S Auerbach, Deepak Mav, Suzy M Stiegelmeyer, Ruchir R Shah, Raymond R Tice
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61768 (2013)
Deep sequencing was used to investigate the subchronic effects of 1 ppm aflatoxin B1 (AFB1), a potent hepatocarcinogen, on the male rat liver transcriptome prior to onset of histopathological lesions or tumors. We hypothesized RNA-Seq would reveal mo
Externí odkaz:
https://doaj.org/article/a3b59a1659ee46fb996fa3a880f22e55
Autor:
Arpit Tandon, Brian Howard, Sreenivasa Ramaiahgari, Adyasha Maharana, Stephen Ferguson, Ruchir Shah, B. Alex Merrick
Publikováno v:
SLAS Discovery, Vol 27, Iss 1, Pp 29-38 (2022)
High-throughput chemical screening approaches often employ microscopy to capture photomicrographs from multi-well cell culture plates, generating thousands of images that require time-consuming human analysis. To automate this subjective and time-con
Externí odkaz:
https://doaj.org/article/8c6a90be8b5a4ef3855a69a9351185fd
Autor:
Julie F. Foley, Brian Elgart, Dhiral Phadke, Deepak Mav, Ignacio Tripodi, Nicholas Clausen, Madeleine Weick, Wes Gladwell, Kevin Gerrish, Ruchir Shah, B. Alex Merrick
Publikováno v:
Journal of Applied Toxicology.
Publikováno v:
Genomic and Epigenomic Biomarkers of Toxicology and Disease. :395-413
Autor:
Wei Qu, Yitang Yan, Kevin Gerrish, Erica Scappini, Charles J. Tucker, Darlene Dixon, B. Alex Merrick
Publikováno v:
Toxicology in Vitro. 89:105577
Autor:
Julie F. Foley, Ruchir R. Shah, B. Alex Merrick, Molly E. Cook, Jason A. Malphurs, Michael B. Fessler, Brian Elgart, Frederick J.W. Miller, Dhiral P. Phadke, Kevin E. Gerrish, Gregory G. Solomon
Publikováno v:
Physiological Reports
Physiological Reports, Vol 9, Iss 15, Pp n/a-n/a (2021)
Physiological Reports, Vol 9, Iss 15, Pp n/a-n/a (2021)
Cell‐free DNA circulates in plasma at low levels as a normal by‐product of cellular apoptosis. Multiple clinical pathologies, as well as environmental stressors can lead to increased circulating cell‐free DNA (ccfDNA) levels. Plasma DNA studies