Zobrazeno 1 - 10
of 232
pro vyhledávání: '"B A O'Connor"'
Autor:
Patrick B. F. O’Connor, Jennifer Mahony, Eoghan Casey, Pavel V. Baranov, Douwe van Sinderen, Martina M. Yordanova
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 4 (2024)
ABSTRACTBacteria have evolved diverse defense mechanisms to counter bacteriophage attacks. Genetic programs activated upon infection characterize phage–host molecular interactions and ultimately determine the outcome of the infection. In this study
Externí odkaz:
https://doaj.org/article/686b9e90ff334a5f9f68107dec1dc818
Autor:
A. van Haandel, J. L. Kerr, J. Laban, X. Massart, T. J. Murray, B. C. O’Connor, S. M. Pawson, C. M. Romo, S. Walker
Publikováno v:
New Zealand Journal of Forestry Science, Vol 47, Iss 1, Pp 1-9 (2017)
Abstract Background Irradiation is accepted as a phytosanitary treatment for horticultural products by many countries. Irradiation is a potential alternative to chemical fumigation for wood products; however, data supporting its efficacy against pote
Externí odkaz:
https://doaj.org/article/06021dc7c813482595cd874167f324f4
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Ribosome profiling data can suffer from uneven coverage which hampers estimation of elongation rates. Connor et al.present an enhanced data smoothing method for Ribo-seq data and highlight significant variability in sequence determinants of ribosome
Externí odkaz:
https://doaj.org/article/42f88ac9182b471484c206f16074bb5e
Autor:
Fabio Hedayioglu, Emma J Mead, Patrick B F O'Connor, Matas Skiotys, Owen J Sansom, Giovanna R Mallucci, Anne E Willis, Pavel V Baranov, C Mark Smales, Tobias von der Haar
Publikováno v:
Nucleic acids research. 50(19)
The assessment of transcriptome-wide ribosome binding to mRNAs is useful for studying the dynamic regulation of protein synthesis. Two methods frequently applied in eukaryotic cells that operate at different levels of resolution are polysome profilin
Autor:
Darren A Fenton, Michał Świrski, Patrick B F O’Connor, Stephen J Kiniry, Audrey M Michel, Joanna Kufel, Pavel V Baranov, John P Morrissey
The coding potential of the eukaryotic genome can be greatly expanded by the regulated use of mechanisms that generate more than one protein product from a gene. We combined techniques for mapping 5’ and 3’ ends of RNA transcripts with ribosome p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51f4cb5817bbff8302ef46f97cb2391d
https://doi.org/10.1101/2022.03.25.485750
https://doi.org/10.1101/2022.03.25.485750
Autor:
Marina V. Serebryakova, Petr N. Datskevich, Audrey M. Michel, Ivan N. Shatsky, Maria S Mikhaylova, Patrick B F O'Connor, John F. Atkins, Pavel V. Baranov, Sergey I. Kovalchuk, Dmitri B. Papkovsky, Stephen J Kiniry, Gary Loughran, Dmitry E. Andreev, Alexander V. Zhdanov, Fedor N. Rozov
Publikováno v:
Proc Natl Acad Sci U S A
While near-cognate codons are frequently used for translation initiation in eukaryotes, their efficiencies are usually low (
Autor:
Patrick B F O'Connor, Victor Koteliansky, Robert Langer, Timofei S. Zatsepin, Pavel V. Baranov, Daniel G. Anderson, Maxim V. Gerashchenko, Kevin J. Kauffman, Vadim N. Gladyshev, Anna S. Fefilova, Charles A. Whittaker, Elena M. Smekalova, Roman L. Bogorad
Publikováno v:
Elsevier
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
© 2019 Translation is an essential biological process, and dysregulation is associated with a range of diseases including ribosomopathies, diabetes, and cancer. Here, we examine translation dysregulation in vivo using RNAi to knock down the m-subuni
Autor:
Alexander V. Zhdanov, John F. Atkins, Ivan N. Shatsky, Stephen J Kiniry, Petr N. Datskevich, Maria S Mikhaylova, Sergey I. Kovalchuk, Marina V. Serebryakova, Fedor N. Rozov, Audrey M. Michel, Pavel V. Baranov, Gary Loughran, Patrick B F O'Connor, Dmitri B. Papkovsky, Dmitry E. Andreev
While near cognate codons are frequently used for translation initiation in eukaryotes, their efficiencies are usually low (POLGmRNA initiates almost as efficiently (~60-70%) as an AUG in optimal context. This CUG directs translation of a conserved 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f8087d1789303bd57ce8e10c000e3e
Autor:
Sinéad O’Loughlin, Ekaterina Samatova, Patrick B F O'Connor, Pavel V. Baranov, Jonathan S. Weissman, Arthur Coakley, John F. Atkins, Gary Loughran, Joseph D. Puglisi, Marina V. Rodnina, Mariia Klimova, Norma M. Wills, Mark C. Capece
Publikováno v:
Journal of Molecular Biology
Efficient translational bypassing of a 50 nt non-coding gap in a phage T4 topoisomerase subunit gene (gp60) requires several recoding signals. Here we investigate the function of the mRNA stem loop 5′ of the take-off codon, as well as the importanc
Autor:
Dmitri B. Papkovsky, Pavel V. Baranov, Maria S. Benitez-Cantos, Martina M. Yordanova, Dmitry E. Andreev, Patrick B F O'Connor, Alexander V. Zhdanov, Sergey I. Kovalchuk
Publikováno v:
Genome Res
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Eukaryotic translation initiation involves preinitiation ribosomal complex 5′ -to-3′ directional probing of mRNA for codons suitable for starting protein synthesis. The recognition of codons as starts depends on the codon identity and on its imme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa867b70124283509b4ae14c40fc4afd
http://hdl.handle.net/10481/64164
http://hdl.handle.net/10481/64164