Výsledky vyhledávání - "B A Hamilton"

Akademický článek

TYROBP/DAP12 knockout in Huntington’s disease Q175 mice cell-autonomously decreases microglial expression of disease-associated genes and non-cell-autonomously mitigates astrogliosis and motor deterioration

Autor: Jordi Creus-Muncunill, Jean Vianney Haure-Mirande, Daniele Mattei, Joanna Bons, Angie V. Ramirez, B. Wade Hamilton, Chuhyon Corwin, Sarah Chowdhury, Birgit Schilling, Lisa M. Ellerby, Michelle E. Ehrlich

Publikováno v: Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-26 (2024)

Abstract Introduction Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by an expansion of the CAG trinucleotide repeat in the Huntingtin gene (HTT). Immune activation is abundant in the striatum of HD patients. Detection of ac

Externí odkaz: https://doaj.org/article/b2af945c340e484f850a0185183190e3

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Akademický článek

Postnatal Conditional Deletion of Bcl11b in Striatal Projection Neurons Mimics the Transcriptional Signature of Huntington’s Disease

Autor: Sicheng Song, Jordi Creus Muncunill, Carlos Galicia Aguirre, Kizito-Tshitoko Tshilenge, B. Wade Hamilton, Akos A. Gerencser, Houda Benlhabib, Maria-Daniela Cirnaru, Mark Leid, Sean D. Mooney, Lisa M. Ellerby, Michelle E. Ehrlich

Publikováno v: Biomedicines, Vol 10, Iss 10, p 2377 (2022)

The dysregulation of striatal gene expression and function is linked to multiple diseases, including Huntington’s disease (HD), Parkinson’s disease, X-linked dystonia-parkinsonism (XDP), addiction, autism, and schizophrenia. Striatal medium spiny

Externí odkaz: https://doaj.org/article/4bd87685543d46c2b0b873499ca2ac64

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Microglial INPP5D limits plaque formation and glial reactivity in the PSAPP mouse model of Alzheimer's disease

Autor: Emilie L. Castranio, Philip Hasel, Jean‐Vianney Haure‐Mirande, Angie V. Ramirez Jimenez, B. Wade Hamilton, Rachel D. Kim, Charles G. Glabe, Minghui Wang, Bin Zhang, Sam Gandy, Shane A. Liddelow, Michelle E. Ehrlich

Publikováno v: Alzheimer's & Dementia.

The inositol polyphosphate-5-phosphatase D (INPP5D) gene encodes a dual-specificity phosphatase that can dephosphorylate both phospholipids and phosphoproteins. Single nucleotide polymorphisms in INPP5D impact risk for developing late onset sporadic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4818097de544fc665949b91f0b448a3
https://doi.org/10.1002/alz.12821

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Akademický článek

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Deletion of the microglial transmembrane immune signaling adaptor TYROBP ameliorates Huntington’s disease mouse phenotype

Autor: Jordi Creus-Muncunill, Daniele Mattei, Joanna Bons, Angie V. Ramirez-Jimenez, B. Wade Hamilton, Chuhyon Corwin, Sarah Chowdhury, Birgit Schilling, Lisa Ellerby, Michelle E. Ehrlich

BACKGROUNDHuntington’s disease (HD) is a fatal neurodegenerative disorder caused by an expansion of the CAG trinucleotide repeat in the huntingtin gene. Immune activation is abundant in the striatum of HD patients. Detection of active microglia at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bce1fd1e242772557d07b5d5971fea0d
https://doi.org/10.1101/2022.02.18.480944

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