Structural basis for the rescue of hyperexcitable cells by the amyotrophic lateral sclerosis drug Riluzole

Autor: David Hollingworth, Frances Thomas, Dana A. Page, Mohamed A. Fouda, Raquel Lopez-Rios De Castro, Altin Sula, Vitaliy B. Mykhaylyk, Geoff Kelly, Martin B. Ulmschneider, Peter C. Ruben, B. A. Wallace

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract Neuronal hyperexcitability is a key element of many neurodegenerative disorders including the motor neuron disease Amyotrophic Lateral Sclerosis (ALS), where it occurs associated with elevated late sodium current (INaL). INaL results from in

Externí odkaz: https://doaj.org/article/eeabfb2a411349818eb73589abebceae

Extension of the AIOMFAC model by iodine and carbonate species: applications for aerosol acidity and cloud droplet activation

Autor: H. Yin, J. Dou, L. Klein, U. K. Krieger, A. Bain, B. J. Wallace, T. C. Preston, A. Zuend

Publikováno v: Atmospheric Chemistry and Physics, Vol 22, Pp 973-1013 (2022)

Iodine and carbonate species are important components in marine and dust aerosols, respectively. The non-ideal interactions between these species and other inorganic and organic compounds within aqueous particle phases affect hygroscopicity, acidity,

Externí odkaz: https://doaj.org/article/c66e4584c9304a7fb91f64443d175e32

2 THE NATURE OF REALITY

Autor: Sean Carroll, B. Alan Wallace

Publikováno v: Great Minds Don’t Think Alike ISBN: 9780231555371

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::69580e14556eb7578399b6b6bc521a39
https://doi.org/10.7312/glei20410-003

The 1.28 GHz MeerKAT Galactic Center Mosaic

Autor: I. Heywood, I. Rammala, F. Camilo, W. D. Cotton, F. Yusef-Zadeh, T. D. Abbott, R. M. Adam, G. Adams, M. A. Aldera, K. M. B. Asad, E. F. Bauermeister, T. G. H. Bennett, H. L. Bester, W. A. Bode, D. H. Botha, A. G. Botha, L. R. S. Brederode, S. Buchner, J. P. Burger, T. Cheetham, D. I. L. de Villiers, M. A. Dikgale-Mahlakoana, L. J. du Toit, S. W. P. Esterhuyse, B. L. Fanaroff, S. February, D. J. Fourie, B. S. Frank, R. R. G. Gamatham, M. Geyer, S. Goedhart, M. Gouws, S. C. Gumede, M. J. Hlakola, A. Hokwana, S. W. Hoosen, J. M. G. Horrell, B. Hugo, A. I. Isaacson, G. I. G. Józsa, J. L. Jonas, A. F. Joubert, R. P. M. Julie, F. B. Kapp, J. S. Kenyon, P. P. A. Kotzé, N. Kriek, H. Kriel, V. K. Krishnan, R. Lehmensiek, D. Liebenberg, R. T. Lord, B. M. Lunsky, K. Madisa, L. G. Magnus, O. Mahgoub, A. Makhaba, S. Makhathini, J. A. Malan, J. R. Manley, S. J. Marais, A. Martens, T. Mauch, B. C. Merry, R. P. Millenaar, N. Mnyandu, O. J. Mokone, T. E. Monama, M. C. Mphego, W. S. New, B. Ngcebetsha, K. J. Ngoasheng, M. T. Ockards, N. Oozeer, A. J. Otto, S. S. Passmoor, A. A. Patel, A. Peens-Hough, S. J. Perkins, A. J. T. Ramaila, N. M. R. Ramanujam, Z. R. Ramudzuli, S. M. Ratcliffe, A. Robyntjies, S. Salie, N. Sambu, C. T. G. Schollar, L. C. Schwardt, R. L. Schwartz, M. Serylak, R. Siebrits, S. K. Sirothia, M. Slabber, O. M. Smirnov, L. Sofeya, B. Taljaard, C. Tasse, A. J. Tiplady, O. Toruvanda, S. N. Twum, T. J. van Balla, A. van der Byl, C. van der Merwe, V. Van Tonder, R. Van Wyk, A. J. Venter, M. Venter, B. H. Wallace, M. G. Welz, L. P. Williams, B. Xaia

The inner $\sim$200 pc region of the Galaxy contains a 4 million M$_{\odot}$ supermassive black hole (SMBH), significant quantities of molecular gas, and star formation and cosmic ray energy densities that are roughly two orders of magnitude higher t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28fe7ee4d1e1621d3fd4322adc908210

Photon upconversion for the enhancement of microfluidic photochemical synthesis

Autor: Aaron P. Esser-Kahn, Brittany A. Moser, Rachel C. Steinhardt, Timothy McCormick Steeves, M. Wu, A. Figueroa, B. M. Wallace, S. T. Kim

Publikováno v: RSC Advances. 9:26172-26175

Photochemical transformations are greatly improved in yield by fluidic reactor technology. However, the delivery of synthetically-active light to the reactants is a challenge. Here, we use upconversion in a bio-inspired microreactor to augment the fl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd0219e4544dc47dc678ad0c4a18f80d
https://doi.org/10.1039/c9ra03468d