Zobrazeno 1 - 10
of 30
pro vyhledávání: '"B A, Larder"'
Autor:
H C Lane, D. Wang, Peter Reiss, Brian Gazzard, A.I. van Sighem, Sean Emery, Julio S. G. Montaner, B. A. Larder, Andrew D. Revell, Mark A. Boyd
Publikováno v:
HIV Medicine. 15:442-448
Objectives: We compared the use of computational models developed with and without HIV genotype vs. genotyping itself to predict effective regimens for patients experiencing first-line virological failure. Methods: Two sets of models predicted virolo
Autor:
Kurt Hertogs, R Pauwels, S. D. Kemp, Schlomo Staszewski, Veronica Miller, Martin Stürmer, Jingshan Ren, B. A. Larder, David I. Stuart, David K. Stammers, R. L. Desmet, Stuart Bloor
Publikováno v:
Scopus-Elsevier
To investigate the occurrence of multinucleoside analog resistance during therapy failure, we surveyed the drug susceptibilities and genotypes of nearly 900 human immunodeficiency virus type 1 (HIV-1) samples. For 302 of these, the 50% inhibitory con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0c8f4e46ae7c1f82b43696643b47260
https://ora.ox.ac.uk/objects/uuid:c02b6582-c197-4b96-8d40-3b9caf461d22
https://ora.ox.ac.uk/objects/uuid:c02b6582-c197-4b96-8d40-3b9caf461d22
Autor:
Jingshan Ren, B. A. Larder, Johan Lennerstrand, P.P. Chamberlain, C.E. Nichols, L. Douglas, David K. Stammers, David I. Stuart
Publikováno v:
Journal of Virology. 76:10015-10019
Six structures of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) containing combinations of resistance mutations for zidovudine (AZT) (M41L and T215Y) or lamivudine (M184V) have been determined as inhibitor complexes. Minimal
Autor:
A D, Revell, M A, Boyd, D, Wang, S, Emery, B, Gazzard, P, Reiss, A I, van Sighem, J S, Montaner, H C, Lane, B A, Larder
Publikováno v:
HIV medicine. 15(7)
We compared the use of computational models developed with and without HIV genotype vs. genotyping itself to predict effective regimens for patients experiencing first-line virological failure.Two sets of models predicted virological response for 99
Autor:
C. Holtzer, E. Race, Kurt Hertogs, William W. Hall, Richard Harrigan, B Clotet, Deenan Pillay, Jean-Claude Schmit, G. De Schrijver, B. A. Larder, Veronica Miller, Anne-Mieke Vandamme, Anders Sönnerborg, Nicholas S. Hellmann, Rob Schuurman, François Houÿez, E. Shulse, D. Bànhegyi, K De Smet
Publikováno v:
Scopus-Elsevier
Europe PubMed Central
ResearcherID
Europe PubMed Central
ResearcherID
HIV drug resistance is one of the major limitations in the successful treatment of HIV-infected patients using currently available antiretroviral combination therapies. When appropriate, drug susceptibility profiles should be taken into consideration
Autor:
A D, Revell, D, Wang, R, Wood, C, Morrow, H, Tempelman, R L, Hamers, G, Alvarez-Uria, A, Streinu-Cercel, L, Ene, A M J, Wensing, F, DeWolf, M, Nelson, J S, Montaner, H C, Lane, B A, Larder, Maria-Jesus, Perez-Elias
Publikováno v:
Journal of antimicrobial chemotherapy, 68(6), 1406-1414. Oxford University Press
Journal of Antimicrobial Chemotherapy, 68(6), 1406-1414. Oxford University Press
Journal of Antimicrobial Chemotherapy, 68(6), 1406-1414. Oxford University Press
Genotypic HIV drug-resistance testing is typically 6065 predictive of response to combination antiretroviral therapy (ART) and is valuable for guiding treatment changes. Genotyping is unavailable in many resource-limited settings (RLSs). We aimed to
Autor:
S D Kemp, Kevin N. Pennington, S Bloor, M H St Clair, B A Larder, Robert T. Schooley, A. Kohli, P R Harrigan, J M Lange
Publikováno v:
Journal of virology, 70(9), 5922-5929. American Society for Microbiology
Human immunodeficiency virus type 1 (HIV-1) isolates obtained prior to and during a combination therapy trial comparing zidovudine (AZT; 3'-azidothymidine) monotherapy with AZT plus 2',3'-dideoxyinosine (ddI) or AZT plus 2',3'-dideoxycytidine (ddC) w
Autor:
B A Larder, Simon F. Lacey
Publikováno v:
Antimicrobial Agents and Chemotherapy. 38:1428-1432
We have selected a human immunodeficiency virus type 1 (HIV-1) mutant strain with a moderate (sevenfold) level of resistance to the nucleoside analog 2',3'-didehydro-2',3'-dideoxythymidine (D4T or stavudine). After serial passage of the HXB2 strain o
Autor:
B A Larder, Simon F. Lacey
Publikováno v:
Journal of Virology. 68:3421-3424
Mutation in the human immunodeficiency virus type 1 reverse transcriptase (RT) at codon 215 has been shown to play a significant role in resistance to zidovudine (AZT). Substitution of threonine with tyrosine or phenylalanine alone confers decreased
Autor:
R. Van Leeuwen, J. Tijnagel, J. M. A. Lange, Charles A. Boucher, B. A. Larder, Paul Kellam, P. Schipper
Publikováno v:
Antimicrobial Agents and Chemotherapy. 37:1525-1530
Zidovudine treatment of individuals infected with human immunodeficiency virus type 1 (HIV-1) results in HIV-1 isolates with a reduced zidovudine sensitivity in vitro. This reduction is due to mutations causing amino acid substitutions at five codons