Zobrazeno 1 - 10
of 1 121
pro vyhledávání: '"B‐cell malignancies"'
Autor:
Lian-Fang Pu, Hui-Min Zheng, Xiang-Jiang Feng, Alice Charwudzi, Xue Liang, Lin-Hui Hu, Yang-Yang Ding, Ze-Lin Liu, Ya Liao, Shu-Dao Xiong
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background CD19-targeted chimeric antigen receptor T (CAR-T) cell therapy stands out as a revolutionary intervention, exhibiting remarkable remission rates in patients with refractory/relapsed (R/R) B-cell malignancies. However, the potentia
Externí odkaz:
https://doaj.org/article/e50289f53c6f44b2a90bdaf69002d041
Autor:
Rens Peeters, Julia Jellusova
Publikováno v:
Molecular Oncology, Vol 18, Iss 7, Pp 1795-1813 (2024)
In recent years, the field of immunometabolism has solidified its position as a prominent area of investigation within the realm of immunological research. An expanding body of scientific literature has unveiled the intricate interplay between energy
Externí odkaz:
https://doaj.org/article/8ef861e4f0f94ec3b6b47a7d1a970824
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundBeta-2 microglobulin (β2M) is acknowledged as a prognostic biomarker for B-cell malignancies. However, insights into the impact of β2M on B-cell malignancy risk, and vice versa, are limited.MethodsWe conducted a genome-wide meta-analysis
Externí odkaz:
https://doaj.org/article/ff9f407c44774701acd84fe2a82ce800
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/a9a8996edca849559e3286979818e7ad
Autor:
Yaqing Qie, Martha E. Gadd, Qing Shao, Tommy To, Andrew Liu, Shuhua Li, Rocio Rivera‐Valentin, Farah Yassine, Hemant S. Murthy, Roxana Dronca, Mohamed A. Kharfan‐Dabaja, Hong Qin, Yan Luo
Publikováno v:
MedComm, Vol 5, Iss 9, Pp n/a-n/a (2024)
Abstract The challenge of disease relapsed/refractory (R/R) remains a therapeutic hurdle in chimeric antigen receptor (CAR) T‐cell therapy, especially for hematological diseases, with chronic lymphocytic leukemia (CLL) being particularly resistant
Externí odkaz:
https://doaj.org/article/2f29030e86d846d6bad6c794841fdd0f
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-4 (2024)
Abstract Chimeric antigen receptors (CAR) are engineered fusion proteins that target T-cells to specific surface antigens of tumor cells to generate effective anti-tumor responses. CAR T-cell therapy is playing an increasingly important role in the t
Externí odkaz:
https://doaj.org/article/b1fbcb0aac43433bb57ee097a45ff9b1
Autor:
Liya Shen, Shuqi Yan, Aoyu Xu, Di Lan, Xue Jiang, Yuehan Peng, Songjun Wang, Zhanzhong Wang, Yongyan Chen
Publikováno v:
Heliyon, Vol 10, Iss 12, Pp e33145- (2024)
CD19 is a surface antigen on B cells that regulates B cell activation and proliferation, participating in B cell signaling. It is expressed in all B cell lineage tumor diseases, making CD19 a significant marker for detecting B cell tumor diseases and
Externí odkaz:
https://doaj.org/article/12d022aa6b4c42c4a27e8a64d3303df3
Publikováno v:
Cancer Medicine, Vol 12, Iss 18, Pp 18767-18785 (2023)
Abstract Background The efficacy of CD22 or CD19 chimeric antigen receptor T (CAR‐T) cells in the management of acute lymphoblastic leukemia (ALL) and non‐Hodgkin lymphoma (NHL) was observed. Because antigen loss and lack of CAR‐T‐cell persis
Externí odkaz:
https://doaj.org/article/14150acabd0f40c0b61dbd02d0da9fd2
Autor:
Kyrillus S. Shohdy, Manon Pillai, Ryan Guest, Dominic Rothwell, Natalia Kirillova, Shien Chow, David Gilham, Fiona Thistlethwaite, Robert Hawkins
Publikováno v:
eJHaem, Vol 4, Iss 3, Pp 882-885 (2023)
Abstract The persistence and reactivity of CAR T cells were enhanced by adding co‐stimulatory domains, which is the basis of currently approved CAR‐T cell therapies. However, this comes at the expense of increasing toxicities from the strong cyto
Externí odkaz:
https://doaj.org/article/f080ad1392f64c9c93c2ca458278ac2c
Autor:
Giovanni Manfredi Assanto ,, Matteo Totaro, Poggiali Rebecca, Delli Paoli Adele, Annechini Giorgia, D’Elia Gianna Maria, Aji Francesco, Petrucci Luigi, Fazio Francesca, Del Giudice Ilaria, Martelli Maurizio, Micozzi Alessandra, Giuseppe Gentile
Publikováno v:
Mediterranean Journal of Hematology and Infectious Diseases, Vol 15, Iss 1 (2023)
Severe Acute Respiratory Syndrome CoronaVirus‐2 (SARS‐CoV‐2) infection can result in different clinical manifestations (COVID-19), starting from asymptomatic disease to life threatening respiratory insufficiency. Onco-haematologic patients are
Externí odkaz:
https://doaj.org/article/2333e79f73004c0eb7baff70540cfd15