Zobrazeno 1 - 10
of 955
pro vyhledávání: '"B‐cell lymphoma 2"'
Autor:
Ayodeji Johnson Ajibare, Adeyemi Fatai Odetayo, Olabode Oluwadare Akintoye, Luqman Aribidesi Olayaki
Publikováno v:
Redox Report, Vol 29, Iss 1 (2024)
Background: Acrylamide is a toxic substance formed in some foods that require high-temperature cooking processes and has been implicated as a gonadotoxic agent. Zinc, on the other hand, is a known antioxidant with fertility-enhancing properties. Henc
Externí odkaz:
https://doaj.org/article/07961a866df34a028b2f910f0beb1284
Publikováno v:
Hematology, Vol 29, Iss 1 (2024)
Venetoclax is a selective inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (BCL2), as a targeted therapy for multiple myeloma (MM) patients. It was initially approved by the United States Food and Drug Administration for the treatment of chr
Externí odkaz:
https://doaj.org/article/9c59153d5af146aeb7865719eb56c1fe
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 4, Pp 2946-2960 (2024)
Targeting the FLT3 receptor and the IL-1R associated kinase 4 as well as the anti-apoptotic proteins MCL1 and BCL2 may be a promising novel approach in the treatment of acute myeloid leukemia (AML). The FLT3 and IRAK4 inhibitor emavusertib (CA4948),
Externí odkaz:
https://doaj.org/article/ab41290b58f549f1851ded0efc64d10f
Autor:
Muhammad Fakhar-e-Alam Kulyar, Quan Mo, Wangyuan Yao, Yan Li, Shah Nawaz, Kyein San Loon, Ahmed Ezzat Ahmed, Aiman A. Alsaegh, Khalid M. Al Syaad, Muhammad Akhtar, Zeeshan Ahmad Bhutta, Jiakui Li, Desheng Qi
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background The B-cell lymphoma 2 (Bcl-2) protein regulates programmed cell death throughout the disease conditions by upholding apoptotic pathways. However, the mechanism by which it’s expressed in chondrocytes still needs to be studied in
Externí odkaz:
https://doaj.org/article/677dd173f641472184ff39094ab90824
Autor:
Akalya Manimaran, Savita Dongapure
Publikováno v:
National Journal of Laboratory Medicine, Vol 13, Iss 01, Pp 47-50 (2024)
Introduction: Endometrial hyperplasia affects both premenopausal and postmenopausal women and is a pathological condition that ranges from mild, reversible glandular proliferations to direct precursors of cancer. B-cell Lymphoma 2 (Bcl-2), an antiapo
Externí odkaz:
https://doaj.org/article/afab1d45fa62446da0d78ca4672d3bb0
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 9, Pp 7011-7026 (2023)
Targeting the molecular chaperone HSP90 and the anti-apoptotic proteins MCL1 and BCL2 may be a promising novel approach in the treatment of acute myeloid leukemia (AML). The HSP90 inhibitor PU-H71, MCL1 inhibitor S63845, and BCL2 inhibitor venetoclax
Externí odkaz:
https://doaj.org/article/e9fd06a271dc4970ac830749cb3a1183
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 4, Iss 4, Pp 583-599 (2023)
Targeting the B-cell lymphoma 2 (Bcl-2) family proteins has been the backbone for hematological malignancies with overall survival improvements. The Bcl-2 family is a major player in apoptosis regulation and, has captured the researcher’s interest
Externí odkaz:
https://doaj.org/article/ab5e7af0e22440349fff7684e5283726
Autor:
Yihua Lin, Yiling Zhao, Minggui Chen, Zishuo Li, Qiao Liu, Jian Chen, Yi Ding, Chunyong Ding, Ye Ding, Cuiling Qi, Lingyun Zheng, Jiangchao Li, Rongxin Zhang, Jia Zhou, Lijing Wang, Qian-Qian Zhang
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-18 (2023)
Abstract Background B-cell lymphoma 2 (Bcl-2) family proteins are key regulators of apoptosis, which possess four conserved Bcl-2 homologies (BH) domains. Among the BH domains, the BH3 domain is considered as a potent ‘death domain’ while the BH4
Externí odkaz:
https://doaj.org/article/d79bd16be6784b4cbe59b5dca56071ea
Autor:
Iuliia Kalashnyk-Vakulenko, Galina Gubina-Vakulyck, Anatolii Onishchenko, Oksana Nakonechna, Tatyana Gorbach, Viktoriya Tkachenko, Anton Tkachenko
Publikováno v:
Ķazaķstannyṇ Klinikalyķ Medicinasy, Vol 19, Iss 6, Pp 63-67 (2022)
Aim: To evaluate expression of anti-apoptotic Bcl-2 protein in the nasal tissue and its levels in blood serum of patients with chronic rhinosinusitis with (CRSwNP) and without nasal polyps (CRSsNP). Material and methods: Expression of Bcl-2 in the si
Externí odkaz:
https://doaj.org/article/7354e3294969420085b991e3b1e63cd4
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