Synergistic lethality in chronic myeloid leukemia - targeting oxidative phosphorylation and unfolded protein response effectively complements tyrosine kinase inhibitor treatment.

Autor: Häselbarth L; Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Erlangen, Germany. lukas.haeselbarth@uk-erlangen.de.; Comprehensive Cancer Center Erlangen-European Metropolitan Area Nuremberg (CCC-ER-EMN), Erlangen, Germany. lukas.haeselbarth@uk-erlangen.de.; Interdisciplinary Centre for Clinical Research (IZKF), Erlangen, Germany. lukas.haeselbarth@uk-erlangen.de., Gamali S; Department of Internal Medicine 5, Hematology and Oncology, University Hospital Erlangen, Erlangen, Germany., Saul D; Department of Internal Medicine 5, Hematology and Oncology, University Hospital Erlangen, Erlangen, Germany., Krumbholz M; Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Erlangen, Germany.; Comprehensive Cancer Center Erlangen-European Metropolitan Area Nuremberg (CCC-ER-EMN), Erlangen, Germany., Böttcher-Loschinski R; Department of Hematology and Oncology, Medical Center, Otto-Von-Guericke University Magdeburg, Magdeburg, Germany., Böttcher M; Department of Hematology and Oncology, Medical Center, Otto-Von-Guericke University Magdeburg, Magdeburg, Germany.; Health Campus Immunology, Inflammation and Infectiology (GC-I3), Medical Center, Otto-Von-Guericke University Magdeburg, Magdeburg, Germany., Zou D; Department of Hematology and Oncology, Medical Center, Otto-Von-Guericke University Magdeburg, Magdeburg, Germany., Metzler M; Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Erlangen, Germany.; Comprehensive Cancer Center Erlangen-European Metropolitan Area Nuremberg (CCC-ER-EMN), Erlangen, Germany.; Interdisciplinary Centre for Clinical Research (IZKF), Erlangen, Germany., Karow A; Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Erlangen, Germany.; Comprehensive Cancer Center Erlangen-European Metropolitan Area Nuremberg (CCC-ER-EMN), Erlangen, Germany.; Interdisciplinary Centre for Clinical Research (IZKF), Erlangen, Germany., Mougiakakos D; Department of Hematology and Oncology, Medical Center, Otto-Von-Guericke University Magdeburg, Magdeburg, Germany.; Health Campus Immunology, Inflammation and Infectiology (GC-I3), Medical Center, Otto-Von-Guericke University Magdeburg, Magdeburg, Germany.

Publikováno v: BMC cancer [BMC Cancer] 2023 Nov 27; Vol. 23 (1), pp. 1153. Date of Electronic Publication: 2023 Nov 27.

TIGIT signaling and its influence on T cell metabolism and immune cell function in the tumor microenvironment.

Autor: Jantz-Naeem N; Institute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany., Böttcher-Loschinski R; Department of Hematology and Oncology, University Hospital Magdeburg, Otto-von-Guericke University Magdeburg, Magdeburg, Germany., Borucki K; Institute of Clinical Chemistry, Department of Pathobiochemistry, Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany., Mitchell-Flack M; Department of Oncology, The Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Böttcher M; Department of Hematology and Oncology, University Hospital Magdeburg, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.; Health Campus Immunology, Infectiology and Inflammation (GCI), Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany., Schraven B; Institute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.; Health Campus Immunology, Infectiology and Inflammation (GCI), Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany., Mougiakakos D; Department of Hematology and Oncology, University Hospital Magdeburg, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.; Health Campus Immunology, Infectiology and Inflammation (GCI), Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany., Kahlfuss S; Institute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.; Health Campus Immunology, Infectiology and Inflammation (GCI), Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.; Institute of Medical Microbiology and Hospital Hygiene, Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.; Center for Health and Medical Prevention (CHaMP), Otto-von-Guericke-University, Magdeburg, Germany.

Publikováno v: Frontiers in oncology [Front Oncol] 2023 Feb 17; Vol. 13, pp. 1060112. Date of Electronic Publication: 2023 Feb 17 (Print Publication: 2023).

CLL-Derived Extracellular Vesicles Impair T-Cell Activation and Foster T-Cell Exhaustion via Multiple Immunological Checkpoints.

Autor: Böttcher M; Department of Hematology and Oncology, University Hospital Magdeburg, Otto-von-Guericke University Magdeburg, 39120 Magdeburg, Germany., Böttcher-Loschinski R; Department of Hematology and Oncology, University Hospital Magdeburg, Otto-von-Guericke University Magdeburg, 39120 Magdeburg, Germany., Kahlfuss S; Institute of Molecular and Clinical Immunology, Medical Faculty, Otto-von-Guericke University Magdeburg, 39120 Magdeburg, Germany.; Health Campus Immunology, Infectiology, and Inflammation (GCI3), Medical Center, Otto-von-Guericke University Magdeburg, 39120 Magdeburg, Germany.; Institute of Medical Microbiology and Hospital Hygiene, Medical Faculty, Otto-von-Guericke University Magdeburg, 39120 Magdeburg, Germany.; ChaMP, Center for Health and Medical Prevention, Otto-von-Guericke University Magdeburg, 39120 Magdeburg, Germany., Aigner M; Medical Department 5-Hematology and Oncology, University Hospital Erlangen, Friedrich-Alexander-University of Erlangen-Nürnberg, 91054 Erlangen, Germany., Gießl A; Department of Ophthalmology, University Hospital Erlangen, Friedrich-Alexander-University of Erlangen-Nürnberg, 91054 Erlangen, Germany., Mackensen A; Medical Department 5-Hematology and Oncology, University Hospital Erlangen, Friedrich-Alexander-University of Erlangen-Nürnberg, 91054 Erlangen, Germany., Schlötzer-Schrehardt U; Department of Ophthalmology, University Hospital Erlangen, Friedrich-Alexander-University of Erlangen-Nürnberg, 91054 Erlangen, Germany., Tüting T; Health Campus Immunology, Infectiology, and Inflammation (GCI3), Medical Center, Otto-von-Guericke University Magdeburg, 39120 Magdeburg, Germany.; Laboratory for Experimental Dermatology, Department of Dermatology, Medical Faculty, Otto-von-Guericke University Magdeburg, 39120 Magdeburg, Germany., Bruns H; Medical Department 5-Hematology and Oncology, University Hospital Erlangen, Friedrich-Alexander-University of Erlangen-Nürnberg, 91054 Erlangen, Germany., Mougiakakos D; Department of Hematology and Oncology, University Hospital Magdeburg, Otto-von-Guericke University Magdeburg, 39120 Magdeburg, Germany.; Health Campus Immunology, Infectiology, and Inflammation (GCI3), Medical Center, Otto-von-Guericke University Magdeburg, 39120 Magdeburg, Germany.; Medical Department 5-Hematology and Oncology, University Hospital Erlangen, Friedrich-Alexander-University of Erlangen-Nürnberg, 91054 Erlangen, Germany.

Publikováno v: Cells [Cells] 2022 Jul 12; Vol. 11 (14). Date of Electronic Publication: 2022 Jul 12.

IL-3 is essential for ICOS-L stabilization on mast cells, and sustains the IL-33-induced RORγt ⁺ T reg generation via enhanced IL-6 induction.

Autor: Drube S; Institut für Immunologie, Universitätsklinikum Jena, Jena, Germany., Müller S; Institut für Immunologie, Universitätsklinikum Jena, Jena, Germany., Weber F; Institut für Immunologie, Universitätsklinikum Jena, Jena, Germany., Wegner P; Institut für Immunologie, Universitätsklinikum Jena, Jena, Germany., Böttcher-Loschinski R; Medizinische Klinik 5, Universitätsklinikum Erlangen, Erlangen, Germany., Gaestel M; Institut für Zellbiochemie, Medizinische Hochschule Hannover, Hannover, Germany., Hutloff A; Institut für Immunologie und Institut für Klinische Molekularbiologie, Universitätsklinikum Schleswig-Holstein, Kiel, Germany., Kamradt T; Institut für Immunologie, Universitätsklinikum Jena, Jena, Germany., Andreas N; Institut für Immunologie, Universitätsklinikum Jena, Jena, Germany.

Publikováno v: Immunology [Immunology] 2021 May; Vol. 163 (1), pp. 86-97. Date of Electronic Publication: 2021 Jan 27.

Impact of Nrf2 expression in reconstituting T-cells of allogeneic hematopoietic stem cell transplanted patients.

Autor: Karl F; Department of Internal Medicine 5, Hematology and Oncology, University of Erlangen-Nuremberg, Erlangen, Germany., Stoll A; Department of Internal Medicine 5, Hematology and Oncology, University of Erlangen-Nuremberg, Erlangen, Germany., Böttcher-Loschinski R; Department of Internal Medicine 5, Hematology and Oncology, University of Erlangen-Nuremberg, Erlangen, Germany., Böttcher M; Department of Internal Medicine 5, Hematology and Oncology, University of Erlangen-Nuremberg, Erlangen, Germany., Baur R; Department of Internal Medicine 5, Hematology and Oncology, University of Erlangen-Nuremberg, Erlangen, Germany., Jacobs B; Department of Internal Medicine 5, Hematology and Oncology, University of Erlangen-Nuremberg, Erlangen, Germany., Völkl S; Department of Internal Medicine 5, Hematology and Oncology, University of Erlangen-Nuremberg, Erlangen, Germany., Jitschin R; Department of Internal Medicine 5, Hematology and Oncology, University of Erlangen-Nuremberg, Erlangen, Germany., Rösler W; Department of Internal Medicine 5, Hematology and Oncology, University of Erlangen-Nuremberg, Erlangen, Germany., Mackensen A; Department of Internal Medicine 5, Hematology and Oncology, University of Erlangen-Nuremberg, Erlangen, Germany., Mougiakakos D; Department of Internal Medicine 5, Hematology and Oncology, University of Erlangen-Nuremberg, Erlangen, Germany. dimitrios.mougiakakos@uk-erlangen.de.

Publikováno v: Leukemia [Leukemia] 2021 Mar; Vol. 35 (3), pp. 910-915. Date of Electronic Publication: 2020 Jul 23.