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Conformational plasticity across phylogenetic clusters of RND multidrug efflux pumps and its impact on substrate specificity.

Autor: Lazarova M; Institute of Biochemistry, Goethe-University Frankfurt, Germany., Eicher T; Institute of Biochemistry, Goethe-University Frankfurt, Germany., Börnsen C; Buchmann Institute for Molecular Life Sciences and Institute of Biophysics, Goethe-University Frankfurt, Germany., Zeng H; Institute of Biochemistry, Goethe-University Frankfurt, Germany., Athar M; Department of Physics, University of Cagliari, Italy., Okada U; Department of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan., Yamashita E; Institute for Protein Research, Osaka University, Japan., Spannaus IM; Institute of Biochemistry, Goethe-University Frankfurt, Germany., Borgosch M; Institute of Biochemistry, Goethe-University Frankfurt, Germany., Cha HJ; Institute of Biochemistry, Goethe-University Frankfurt, Germany., Vargiu AV; Department of Physics, University of Cagliari, Italy., Murakami S; Department of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan., Diederichs K; Department of Biology, University of Konstanz, Germany., Frangakis AS; Buchmann Institute for Molecular Life Sciences and Institute of Biophysics, Goethe-University Frankfurt, Germany., Pos KM; Institute of Biochemistry, Goethe-University Frankfurt, Germany.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Nov 22. Date of Electronic Publication: 2024 Nov 22.