Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Börje Darpö"'
Autor:
Shichang Miao, Peter Staehr, Ezra Tai, Borje Darpo, Hongqi Xue, Danielle Armas, Kenneth Webster, Rajneet K. Oberoi
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 7, Pp n/a-n/a (2024)
Abstract This phase I thorough QTc, double‐blind, randomized, placebo‐ and positive‐controlled, parallel group, multiple‐dose study evaluated avacopan's effect on cardiac repolarization using concentration‐QTc (C‐QTc) as the primary analy
Externí odkaz:
https://doaj.org/article/a9cf4106b51344e988533b466eaadf9d
Autor:
Hironobu Tsukada, Snezana M. Milanovic, Borje Darpo, Hongqi Xue, Kuangnan Xiong, Emily Tripp, Lisa Lennek, MaryAlice Worden, Seth C. Hopkins, Gerald R. Galluppi
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 6, Pp 1063-1074 (2023)
Abstract This study (NCT04369391) evaluated the effects of ulotaront (SEP‐363856), a novel trace amine‐associated receptor 1 (TAAR1) agonist in development for schizophrenia, on electrocardiogram parameters. Study design was a randomized, single
Externí odkaz:
https://doaj.org/article/fb931202cdb44672bb881bd23a3cb680
Autor:
Borje Darpo, Michal Geva, Georg Ferber, Yigal Paul Goldberg, Andres Cruz-Herranz, Munish Mehra, Richard Kovacs, Michael R. Hayden
Publikováno v:
Neurology and Therapy, Vol 12, Iss 2, Pp 597-617 (2023)
Abstract Introduction Pridopidine is a highly selective sigma-1 receptor (S1R) agonist in development for the treatment of Huntington’s disease (HD) and amyotrophic lateral sclerosis (ALS). Pridopidine’s activation of S1R enhances cellular proces
Externí odkaz:
https://doaj.org/article/8aac3a828618475eb11cb8502f0f5d75
Autor:
Sibel Ucpinar, Borje Darpo, Ann Neale, Philip Nunn, Jin Shu, Katherine A. Chu, Marianne Kavanagh, Hongqi Xue, Pasit Phiasivongsa, Dolca Thomas, Patrick F. Smith
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 6, Pp 1507-1518 (2022)
Abstract This study aimed to define the clinically relevant supratherapeutic dose of rilzabrutinib, an oral Bruton tyrosine kinase (BTK) inhibitor, and evaluate potential effects of therapeutic and supratherapeutic exposures on cardiac repolarization
Externí odkaz:
https://doaj.org/article/3418278264b64f71bc273037eb1ad05f
Autor:
Markus S. Mueller, Patricia N. Sidharta, Christine Voors-Pette, Borje Darpo, Hongqi Xue, Jasper Dingemanse
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 15, Iss 1, Pp 1-15 (2020)
Abstract Background Fabry disease is a rare inherited glycosphingolipid storage disorder caused by deleterious mutations in the GLA gene coding for the lysosomal enzyme α-galactosidase A. The glucosylceramide synthase inhibitor lucerastat is an imin
Externí odkaz:
https://doaj.org/article/f0abba24de554ee6a78152eb628f9a5e
Autor:
Song Mu, Borje Darpo, Zhiyu Tang, William Novotny, Manal Tawashi, Hongqi Xue, Michael Willett, Leo Lin, Sri Sahasranaman, Ying C. Ou
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 5, Pp 923-931 (2020)
This thorough QT (TQT) study evaluated the effect of zanubrutinib on electrocardiogram (ECG) parameters by using concentration‐QTc (C‐QTc) analysis as the primary analysis for this study. Part A of the study determined the safety and tolerability
Externí odkaz:
https://doaj.org/article/e0ea160c88114e70927aa41ba7867992
Publikováno v:
Annals of Noninvasive Electrocardiology, Vol 26, Iss 4, Pp n/a-n/a (2021)
Abstract Background The risk of ventricular arrhythmias in patients on QT prolonging drugs is indicated to be increased early after cardioversion (CV) of atrial fibrillation (AF) to sinus rhythm (SR). Sotalol, used to prevent AF relapse, prolongs car
Externí odkaz:
https://doaj.org/article/eff5e8a9be0d4e52aa3b0ccf7aa369be
Autor:
Hans Vallin, Börje Darpö, Harry Jgm Crijns, Per Blomström, Birgitta Houltz, Johannes Brachmann, Elisabeth Svernhage, Steen M Jensen, Karl Swedberg, Nils Edvardsson
Publikováno v:
Cardiovascular Drugs and Therapy. 13:329-338
Purpose: To assess the efficacy of the I-kr-blocker almokalant attempting to convert chronic atrial tachyarrhythmias, and to find predictors of conversion, to sinus rhythm. Methods: The electrophysiological effects of a 6-hour infusion of almokalant,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66825095d83b2f5b750bd21c8ce7def2
https://doi.org/10.1023/a:1007759500274
https://doi.org/10.1023/a:1007759500274
Autor:
Steen M. Jensen, Hans Vallin, Johannes Brachmann, Harry J.G.M. Crijns, Elisabeth Svernhage, Birgitta Houltz, Per Blomström, Karl Swedberg, Börje Darpö, Nils Edvardsson
Publikováno v:
Pace-Pacing and Clinical Electrophysiology, 21(5), 1044-1057. Wiley
The aim of this study was to identify predictors of torsades de pointes (TdP) in patients with atrial fibrillation (AF) or flutter exposed to the Class III antiarrhythmic drug almokalant. TdP can be caused by drugs that prolong myocardial repolarizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9b96f3d9f1b3b4c06586ed84051be68
https://doi.org/10.1111/j.1540-8159.1998.tb00150.x
https://doi.org/10.1111/j.1540-8159.1998.tb00150.x
Autor:
Börje Darpö, Nils Edvardsson
Publikováno v:
Cardiovascular Drugs and Therapy. 11:499-508
The aim of the present study was to investigate the effects of almokalant on sustained reentrant supraventricular tachycardias. Reentrant tachycardias were induced, using transesophageal atrial stimulation, in 82 patients with atrioventricular reentr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b6f139138d8aac290009df188b7d867
https://doi.org/10.1023/a:1007761825414
https://doi.org/10.1023/a:1007761825414