Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours.

Autor: Brenner E; Department of Dermatology, University of Tübingen, 72076, Tübingen, Germany., Schörg BF; Department of Preclinical Imaging and Radiopharmacy, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens-Foundation, University of Tübingen, 72076, Tübingen, Germany., Ahmetlić F; Institut für Molekulare Immunologie, Helmholtz-Zentrum München, 81377, Munich, Germany.; Eigenständige Forschungseinheit Translationale Molekulare Immunologie, Helmholtz Zentrum München, 81377, Munich, Germany., Wieder T; Department of Dermatology, University of Tübingen, 72076, Tübingen, Germany., Hilke FJ; Institute of Medical Genetics and Applied Genomics, University of Tübingen, 72076, Tübingen, Germany., Simon N; Department of Dermatology, University of Tübingen, 72076, Tübingen, Germany., Schroeder C; Institute of Medical Genetics and Applied Genomics, University of Tübingen, 72076, Tübingen, Germany., Demidov G; Institute of Medical Genetics and Applied Genomics, University of Tübingen, 72076, Tübingen, Germany., Riedel T; Institut für Molekulare Immunologie, Helmholtz-Zentrum München, 81377, Munich, Germany., Fehrenbacher B; Department of Dermatology, University of Tübingen, 72076, Tübingen, Germany., Schaller M; Department of Dermatology, University of Tübingen, 72076, Tübingen, Germany., Forschner A; Department of Dermatology, University of Tübingen, 72076, Tübingen, Germany., Eigentler T; Department of Dermatology, University of Tübingen, 72076, Tübingen, Germany., Niessner H; Department of Dermatology, University of Tübingen, 72076, Tübingen, Germany., Sinnberg T; Department of Dermatology, University of Tübingen, 72076, Tübingen, Germany., Böhm KS; Department of Dermatology, University of Tübingen, 72076, Tübingen, Germany., Hömberg N; Institut für Molekulare Immunologie, Helmholtz-Zentrum München, 81377, Munich, Germany.; Eigenständige Forschungseinheit Translationale Molekulare Immunologie, Helmholtz Zentrum München, 81377, Munich, Germany., Braumüller H; Department of Dermatology, University of Tübingen, 72076, Tübingen, Germany., Dauch D; Department of Medical Oncology and Pneumology, University Hospital Tübingen, 72076, Tübingen, Germany.; German Cancer Research Consortium (DKTK), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany., Zwirner S; Department of Medical Oncology and Pneumology, University Hospital Tübingen, 72076, Tübingen, Germany., Zender L; Department of Medical Oncology and Pneumology, University Hospital Tübingen, 72076, Tübingen, Germany.; German Cancer Research Consortium (DKTK), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image Guided and Functionally Instructed Tumor Therapies', 72076, Tübingen, Germany., Sonanini D; Department of Preclinical Imaging and Radiopharmacy, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens-Foundation, University of Tübingen, 72076, Tübingen, Germany.; Department of Medical Oncology and Pneumology, University Hospital Tübingen, 72076, Tübingen, Germany., Geishauser A; Institut für Molekulare Immunologie, Helmholtz-Zentrum München, 81377, Munich, Germany.; Eigenständige Forschungseinheit Translationale Molekulare Immunologie, Helmholtz Zentrum München, 81377, Munich, Germany., Bauer J; Department of Dermatology, University of Tübingen, 72076, Tübingen, Germany., Eichner M; Institute of Clinical Epidemiology and Applied Biometry, University of Tübingen, 72076, Tübingen, Germany., Jarick KJ; Department of Medicine II, Würzburg University, 97078, Würzburg, Germany., Beilhack A; Department of Medicine II, Würzburg University, 97078, Würzburg, Germany., Biskup S; Cluster of Excellence iFIT (EXC 2180) 'Image Guided and Functionally Instructed Tumor Therapies', 72076, Tübingen, Germany.; Center for Genomics and Transcriptomics (CeGaT) GmbH and Practice for Human Genetics, 72076, Tübingen, Germany., Döcker D; Department of Dermatology, University of Tübingen, 72076, Tübingen, Germany.; Center for Genomics and Transcriptomics (CeGaT) GmbH and Practice for Human Genetics, 72076, Tübingen, Germany., Schadendorf D; German Cancer Research Consortium (DKTK), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.; Department of Dermatology, University Hospital, West German Cancer Centre, University Duisburg-Essen, 45147, Essen, Germany., Quintanilla-Martinez L; Cluster of Excellence iFIT (EXC 2180) 'Image Guided and Functionally Instructed Tumor Therapies', 72076, Tübingen, Germany.; Institute of Pathology, University of Tübingen, 72076, Tübingen, Germany., Pichler BJ; Department of Preclinical Imaging and Radiopharmacy, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens-Foundation, University of Tübingen, 72076, Tübingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image Guided and Functionally Instructed Tumor Therapies', 72076, Tübingen, Germany., Kneilling M; Department of Dermatology, University of Tübingen, 72076, Tübingen, Germany.; Department of Preclinical Imaging and Radiopharmacy, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens-Foundation, University of Tübingen, 72076, Tübingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image Guided and Functionally Instructed Tumor Therapies', 72076, Tübingen, Germany., Mocikat R; Institut für Molekulare Immunologie, Helmholtz-Zentrum München, 81377, Munich, Germany.; Eigenständige Forschungseinheit Translationale Molekulare Immunologie, Helmholtz Zentrum München, 81377, Munich, Germany., Röcken M; Department of Dermatology, University of Tübingen, 72076, Tübingen, Germany. mrocken@med.uni-tuebingen.de.; German Cancer Research Consortium (DKTK), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. mrocken@med.uni-tuebingen.de.; Cluster of Excellence iFIT (EXC 2180) 'Image Guided and Functionally Instructed Tumor Therapies', 72076, Tübingen, Germany. mrocken@med.uni-tuebingen.de.

Publikováno v: Nature communications [Nat Commun] 2020 Mar 12; Vol. 11 (1), pp. 1335. Date of Electronic Publication: 2020 Mar 12.