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Phenothiazine- and Carbazole-Cyanochalcones as Dual Inhibitors of Tubulin Polymerization and Human Farnesyltransferase.

Autor: Zubaș A; Faculty of Chemistry, 'Alexandru Ioan Cuza' University of Iasi, Bulevardul Carol I, nr. 11, 700506 Iasi, Romania., Ghinet A; Faculty of Chemistry, 'Alexandru Ioan Cuza' University of Iasi, Bulevardul Carol I, nr. 11, 700506 Iasi, Romania.; Junia, Health and Environment, Laboratory of Sustainable Chemistry and Health, 59000 Lille, France.; Institut National de la Santé et de la Recherche Médicale, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE-Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, University of Lille, 59000 Lille, France., Farce A; Institut National de la Santé et de la Recherche Médicale, CHU Lille, U1286-Infinite-Institute for Translational Research in Inflammation, University of Lille, 59000 Lille, France., Dubois J; Institut de Chimie des Substances Naturelles, UPR2301, CNRS, Centre de Recherche de Gif, 91190 Gif-sur-Yvette, France., Bîcu E; Faculty of Chemistry, 'Alexandru Ioan Cuza' University of Iasi, Bulevardul Carol I, nr. 11, 700506 Iasi, Romania.

Publikováno v: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2023 Jun 16; Vol. 16 (6). Date of Electronic Publication: 2023 Jun 16.

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7-Chloroquinolinehydrazones as First-in-Class Anticancer Experimental Drugs in the NCI-60 Screen among Different Investigated Series of Aryl, Quinoline, Pyridine, Benzothiazole and Imidazolehydrazones.

Autor: Negru Apostol G; Faculty of Chemistry, 'Alexandru Ioan Cuza' University of Iasi, Bd. Carol I, nr. 11, 700506 Iasi, Romania., Ghinet A; Faculty of Chemistry, 'Alexandru Ioan Cuza' University of Iasi, Bd. Carol I, nr. 11, 700506 Iasi, Romania.; Junia, Health and Environment, Laboratory of Sustainable Chemistry and Health, F-59000 Lille, France.; Institut National de la Santé et de la Recherche Médicale, Centre Hospitalier Universitaire de Lille, Institut Pasteur Lille, U1167-RID-AGE-Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, University of Lille, F-59000 Lille, France., Bîcu E; Faculty of Chemistry, 'Alexandru Ioan Cuza' University of Iasi, Bd. Carol I, nr. 11, 700506 Iasi, Romania.

Publikováno v: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2023 May 03; Vol. 16 (5). Date of Electronic Publication: 2023 May 03.

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Attempts to Access a Series of Pyrazoles Lead to New Hydrazones with Antifungal Potential against Candida species including Azole-Resistant Strains.

Autor: Negru G; Faculty of Chemistry, 'Alexandru Ioan Cuza' University of Iași, Bd. Carol I 11, 700506 Iași, Romania., Kamus L; Inserm U1285, CHU Lille, UGSF UMR CNRS 8576, Glycobiology in Fungal and Clinical Applications, Unité de Glycobiologie Structurale et Fonctionnelle, University of Lille, 59000 Lille, France., Bîcu E; Faculty of Chemistry, 'Alexandru Ioan Cuza' University of Iași, Bd. Carol I 11, 700506 Iași, Romania., Shova S; 'Petru Poni' Institute of Macromolecular Chemistry, 700487 Iași, Romania., Sendid B; Inserm U1285, CHU Lille, UGSF UMR CNRS 8576, Glycobiology in Fungal and Clinical Applications, Unité de Glycobiologie Structurale et Fonctionnelle, University of Lille, 59000 Lille, France., Dubar F; Inserm U1285, CHU Lille, UGSF UMR CNRS 8576, Glycobiology in Fungal and Clinical Applications, Unité de Glycobiologie Structurale et Fonctionnelle, University of Lille, 59000 Lille, France., Ghinet A; Faculty of Chemistry, 'Alexandru Ioan Cuza' University of Iași, Bd. Carol I 11, 700506 Iași, Romania.; Laboratory of Sustainable Chemistry and Health, Health and Environment Department, Junia, 59000 Lille, France.; Inserm, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE-Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, University of Lille, 59000 Lille, France.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2021 Sep 27; Vol. 26 (19). Date of Electronic Publication: 2021 Sep 27.

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Indolizine-phenothiazine hybrids as the first dual inhibitors of tubulin polymerization and farnesyltransferase with synergistic antitumor activity.

Autor: Moise IM; 'Alexandru Ioan Cuza' University of Iasi, Faculty of Chemistry, Bd. Carol I nr. 11, 700506 Iasi, Romania., Bîcu E; 'Alexandru Ioan Cuza' University of Iasi, Faculty of Chemistry, Bd. Carol I nr. 11, 700506 Iasi, Romania. Electronic address: elena@uaic.ro., Farce A; Univ. Lille, Faculté des Sciences Pharmaceutiques et Biologiques, Rue du Pr Laguesse, B.P. 83, F-59006 Lille, France., Dubois J; Institut de Chimie des Substances Naturelles, UPR2301 CNRS, Centre de Recherche de Gif, Avenue de la Terrasse, F-91198 Gif-sur-Yvette Cedex, France., Ghinet A; 'Alexandru Ioan Cuza' University of Iasi, Faculty of Chemistry, Bd. Carol I nr. 11, 700506 Iasi, Romania; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, F-59000 Lille, France; Yncréa Hauts-de-France, Hautes Etudes d'Ingénieur (HEI), UCLille, Health & Environment Department, Sustainable Chemistry Team, Laboratoire de Chimie Durable et Santé, 13 rue de Toul, F-59046 Lille, France. Electronic address: alina.ghinet@yncrea.fr.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2020 Oct; Vol. 103, pp. 104184. Date of Electronic Publication: 2020 Aug 26.

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Exploring isoxazoles and pyrrolidinones decorated with the 4,6-dimethoxy-1,3,5-triazine unit as human farnesyltransferase inhibitors.

Autor: Lucescu L; Faculty of Chemistry, Al. I. Cuza' University of Iasi, Iasi, Romania., Ghinet A; Faculty of Chemistry, Al. I. Cuza' University of Iasi, Iasi, Romania.; Inserm U995, LIRIC, Faculté de médecine-Pôle recherche, Université de Lille, CHRU de Lille, Lille, France.; Laboratoire de Chimie Durable et Santé, Hautes Etudes d'Ingénieur (HEI), Yncréa Hauts-de-France, UC Lille, Lille, France., Shova S; Petru Poni' Institute of Macromolecular Chemistry, Iasi, Romania., Magnez R; Univ. Lille, UMR-S 1172 - JPARC - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, Lille, France., Thuru X; Univ. Lille, UMR-S 1172 - JPARC - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, Lille, France., Farce A; Inserm U995, LIRIC, Faculté de médecine-Pôle recherche, Université de Lille, CHRU de Lille, Lille, France.; Faculté des Sciences Pharmaceutiques et Biologiques de Lille, Lille, France., Rigo B; Inserm U995, LIRIC, Faculté de médecine-Pôle recherche, Université de Lille, CHRU de Lille, Lille, France.; Laboratoire de Chimie Durable et Santé, Hautes Etudes d'Ingénieur (HEI), Yncréa Hauts-de-France, UC Lille, Lille, France., Belei D; Faculty of Chemistry, Al. I. Cuza' University of Iasi, Iasi, Romania., Dubois J; Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, UPR2301 CNRS, Gif-sur-Yvette, France., Bîcu E; Faculty of Chemistry, Al. I. Cuza' University of Iasi, Iasi, Romania.

Publikováno v: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2019 May; Vol. 352 (5), pp. e1800227. Date of Electronic Publication: 2019 Apr 04.

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Study of the Lipophilicity and ADMET Parameters of New Anticancer Diquinothiazines with Pharmacophore Substituents.

Autor: Klimoszek, Daria¹ (AUTHOR) d201204@365.sum.edu.pl, Jeleń, Małgorzata² (AUTHOR) bmlodawska@sum.edu.pl, Dołowy, Małgorzata¹ (AUTHOR) mdolowy@sum.edu.pl, Morak-Młodawska, Beata² (AUTHOR)

Publikováno v: Pharmaceuticals (14248247). Jun2024, Vol. 17 Issue 6, p725. 21p.

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