Hepatocyte-specific deletion of Pparα promotes NAFLD in the context of obesity

Autor: Régnier, M., Polizzi, A., Smati, S., Lukowicz, C., Fougerat, A., Lippi, Y., Fouché, E., Lasserre, F., Naylies, C., Bétoulières, C., Barquissau, V., Mouisel, E., Bertrand-Michel, J., Batut, A., Saati, T.A., Canlet, C., Tremblay-Franco, M., Ellero-Simatos, S., Langin, D., Postic, C., Wahli, W., Loiseau, N., Guillou, H., Montagner, A.

Publikováno v: Scientific Reports
Scientific Reports, 2020, 10 (1), pp.6489. ⟨10.1038/s41598-020-63579-3⟩
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.6489. ⟨10.1038/s41598-020-63579-3⟩
Scientific reports, vol. 10, no. 1, pp. 6489

Peroxisome proliferator activated receptor α (PPARα) acts as a fatty acid sensor to orchestrate the transcription of genes coding for rate-limiting enzymes required for lipid oxidation in hepatocytes. Mice only lacking Pparα in hepatocytes spontan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::49786ed8db08fd7baa1ce2888766837d
https://hdl.handle.net/10356/144951

Hepatocyte-specific deletion of Pparα promotes NAFLD in the context of obesity.

Autor: Régnier M; Toxalim, INRAE UMR 1331, ENVT, INP-Purpan, University of Toulouse, Paul Sabatier University, F-31027, Toulouse, France., Polizzi A; Toxalim, INRAE UMR 1331, ENVT, INP-Purpan, University of Toulouse, Paul Sabatier University, F-31027, Toulouse, France., Smati S; Toxalim, INRAE UMR 1331, ENVT, INP-Purpan, University of Toulouse, Paul Sabatier University, F-31027, Toulouse, France.; Institut National de la Santé et de la Recherche Médicale (INSERM), UMR1048, Institute of Metabolic and Cardiovascular Diseases, University of Toulouse, Paul Sabatier University, Toulouse, France., Lukowicz C; Toxalim, INRAE UMR 1331, ENVT, INP-Purpan, University of Toulouse, Paul Sabatier University, F-31027, Toulouse, France., Fougerat A; Toxalim, INRAE UMR 1331, ENVT, INP-Purpan, University of Toulouse, Paul Sabatier University, F-31027, Toulouse, France., Lippi Y; Toxalim, INRAE UMR 1331, ENVT, INP-Purpan, University of Toulouse, Paul Sabatier University, F-31027, Toulouse, France., Fouché E; Toxalim, INRAE UMR 1331, ENVT, INP-Purpan, University of Toulouse, Paul Sabatier University, F-31027, Toulouse, France., Lasserre F; Toxalim, INRAE UMR 1331, ENVT, INP-Purpan, University of Toulouse, Paul Sabatier University, F-31027, Toulouse, France., Naylies C; Toxalim, INRAE UMR 1331, ENVT, INP-Purpan, University of Toulouse, Paul Sabatier University, F-31027, Toulouse, France., Bétoulières C; Toxalim, INRAE UMR 1331, ENVT, INP-Purpan, University of Toulouse, Paul Sabatier University, F-31027, Toulouse, France., Barquissau V; Institut National de la Santé et de la Recherche Médicale (INSERM), UMR1048, Institute of Metabolic and Cardiovascular Diseases, University of Toulouse, Paul Sabatier University, Toulouse, France., Mouisel E; Institut National de la Santé et de la Recherche Médicale (INSERM), UMR1048, Institute of Metabolic and Cardiovascular Diseases, University of Toulouse, Paul Sabatier University, Toulouse, France., Bertrand-Michel J; Metatoul-Lipidomic Facility, MetaboHUB, Institut National de la Santé et de la Recherche Médicale (INSERM), UMR1048, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France., Batut A; Metatoul-Lipidomic Facility, MetaboHUB, Institut National de la Santé et de la Recherche Médicale (INSERM), UMR1048, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France., Saati TA; Service d'Histopathologie Expérimentale Unité INSERM/UPS/ENVT-US006/CREFRE Inserm, CHU Purpan, 31024, Toulouse, cedex 3, France., Canlet C; Toxalim, INRAE UMR 1331, ENVT, INP-Purpan, University of Toulouse, Paul Sabatier University, F-31027, Toulouse, France., Tremblay-Franco M; Toxalim, INRAE UMR 1331, ENVT, INP-Purpan, University of Toulouse, Paul Sabatier University, F-31027, Toulouse, France., Ellero-Simatos S; Toxalim, INRAE UMR 1331, ENVT, INP-Purpan, University of Toulouse, Paul Sabatier University, F-31027, Toulouse, France., Langin D; Institut National de la Santé et de la Recherche Médicale (INSERM), UMR1048, Institute of Metabolic and Cardiovascular Diseases, University of Toulouse, Paul Sabatier University, Toulouse, France.; Toulouse University Hospitals, Laboratory of Clinical Biochemistry, Toulouse, France., Postic C; Institut National de la Santé et de la Recherche Médicale (INSERM), U1016, Institut Cochin, Paris, France., Wahli W; Toxalim, INRAE UMR 1331, ENVT, INP-Purpan, University of Toulouse, Paul Sabatier University, F-31027, Toulouse, France.; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Clinical Sciences Building, 11 Mandalay Road, Nanyang, Singapore.; Center for Integrative Genomics, Université de Lausanne, Le Génopode, Lausanne, Switzerland., Loiseau N; Toxalim, INRAE UMR 1331, ENVT, INP-Purpan, University of Toulouse, Paul Sabatier University, F-31027, Toulouse, France., Guillou H; Toxalim, INRAE UMR 1331, ENVT, INP-Purpan, University of Toulouse, Paul Sabatier University, F-31027, Toulouse, France. herve.guillou@inrae.fr., Montagner A; Toxalim, INRAE UMR 1331, ENVT, INP-Purpan, University of Toulouse, Paul Sabatier University, F-31027, Toulouse, France. alexandra.montagner@inserm.fr.; Institut National de la Santé et de la Recherche Médicale (INSERM), UMR1048, Institute of Metabolic and Cardiovascular Diseases, University of Toulouse, Paul Sabatier University, Toulouse, France. alexandra.montagner@inserm.fr.

Publikováno v: Scientific reports [Sci Rep] 2020 Apr 16; Vol. 10 (1), pp. 6489. Date of Electronic Publication: 2020 Apr 16.

The protective role of liver X receptor (LXR) during fumonisin B1-induced hepatotoxicity.

Autor: Régnier M; Toxalim (Research Centre in Food Toxicology), Université de Toulouse, UMR1331 INRA, ENVT, INP-Purpan, UPS, 180, Chemin de Tournefeuille, BP93173, 31027, Toulouse, France., Polizzi A; Toxalim (Research Centre in Food Toxicology), Université de Toulouse, UMR1331 INRA, ENVT, INP-Purpan, UPS, 180, Chemin de Tournefeuille, BP93173, 31027, Toulouse, France., Lukowicz C; Toxalim (Research Centre in Food Toxicology), Université de Toulouse, UMR1331 INRA, ENVT, INP-Purpan, UPS, 180, Chemin de Tournefeuille, BP93173, 31027, Toulouse, France., Smati S; Toxalim (Research Centre in Food Toxicology), Université de Toulouse, UMR1331 INRA, ENVT, INP-Purpan, UPS, 180, Chemin de Tournefeuille, BP93173, 31027, Toulouse, France.; I2MC, Institut National de la Santé et de la Recherche Médicale (INSERM)-U 1048, Université de Toulouse CHU de Toulouse, Toulouse, France., Lasserre F; Toxalim (Research Centre in Food Toxicology), Université de Toulouse, UMR1331 INRA, ENVT, INP-Purpan, UPS, 180, Chemin de Tournefeuille, BP93173, 31027, Toulouse, France., Lippi Y; Toxalim (Research Centre in Food Toxicology), Université de Toulouse, UMR1331 INRA, ENVT, INP-Purpan, UPS, 180, Chemin de Tournefeuille, BP93173, 31027, Toulouse, France., Naylies C; Toxalim (Research Centre in Food Toxicology), Université de Toulouse, UMR1331 INRA, ENVT, INP-Purpan, UPS, 180, Chemin de Tournefeuille, BP93173, 31027, Toulouse, France., Laffitte J; Toxalim (Research Centre in Food Toxicology), Université de Toulouse, UMR1331 INRA, ENVT, INP-Purpan, UPS, 180, Chemin de Tournefeuille, BP93173, 31027, Toulouse, France., Bétoulières C; Toxalim (Research Centre in Food Toxicology), Université de Toulouse, UMR1331 INRA, ENVT, INP-Purpan, UPS, 180, Chemin de Tournefeuille, BP93173, 31027, Toulouse, France., Montagner A; Toxalim (Research Centre in Food Toxicology), Université de Toulouse, UMR1331 INRA, ENVT, INP-Purpan, UPS, 180, Chemin de Tournefeuille, BP93173, 31027, Toulouse, France., Ducheix S; Toxalim (Research Centre in Food Toxicology), Université de Toulouse, UMR1331 INRA, ENVT, INP-Purpan, UPS, 180, Chemin de Tournefeuille, BP93173, 31027, Toulouse, France., Gourbeyre P; Toxalim (Research Centre in Food Toxicology), Université de Toulouse, UMR1331 INRA, ENVT, INP-Purpan, UPS, 180, Chemin de Tournefeuille, BP93173, 31027, Toulouse, France., Ellero-Simatos S; Toxalim (Research Centre in Food Toxicology), Université de Toulouse, UMR1331 INRA, ENVT, INP-Purpan, UPS, 180, Chemin de Tournefeuille, BP93173, 31027, Toulouse, France., Menard S; Toxalim (Research Centre in Food Toxicology), Université de Toulouse, UMR1331 INRA, ENVT, INP-Purpan, UPS, 180, Chemin de Tournefeuille, BP93173, 31027, Toulouse, France., Bertrand-Michel J; MetaToul-Lipidomic Facility-MetaboHUB, INSERM UMR1048, Institute of Cardiovascular and Metabolic Diseases, Université Paul Sabatier-Toulouse III, Toulouse, France., Al Saati T; Histopathology facility, INSERM/UPS/ENVT, US006/CREFRE, Place du Docteur Baylac, CHU Purpan, 31300, Toulouse, France., Lobaccaro JM; GReD, Université de Clermont Auvergne, CNRS, INSERM, 28 Place Henri Dunant, Clermont-Ferrand, France., Burger HM; Institute of Biomedical and Microbial Biotechnology, Cape Peninsula University of Technology, Bellville, South Africa., Gelderblom WC; Institute of Biomedical and Microbial Biotechnology, Cape Peninsula University of Technology, Bellville, South Africa.; Department of Biochemistry, University of Stellenbosch, Matieland, South Africa., Guillou H; Toxalim (Research Centre in Food Toxicology), Université de Toulouse, UMR1331 INRA, ENVT, INP-Purpan, UPS, 180, Chemin de Tournefeuille, BP93173, 31027, Toulouse, France., Oswald IP; Toxalim (Research Centre in Food Toxicology), Université de Toulouse, UMR1331 INRA, ENVT, INP-Purpan, UPS, 180, Chemin de Tournefeuille, BP93173, 31027, Toulouse, France. nicolas.loiseau@inra.fr., Loiseau N; Toxalim (Research Centre in Food Toxicology), Université de Toulouse, UMR1331 INRA, ENVT, INP-Purpan, UPS, 180, Chemin de Tournefeuille, BP93173, 31027, Toulouse, France. isabelle.oswald@inra.fr.

Publikováno v: Archives of toxicology [Arch Toxicol] 2019 Feb; Vol. 93 (2), pp. 505-517. Date of Electronic Publication: 2018 Nov 17.

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Concomitant Sub-Chronic Administration of Small-Size Gold Nanoparticles Aggravates Doxorubicin-Induced Liver Oxidative and Inflammatory Damage, Hyperlipidemia, and Hepatic Steatosis.

Autor: Alshammari, Ghedeir M.¹ (AUTHOR) aghedeir@ksu.edu.sa, Abdelhalim, Mohamed Anwar² (AUTHOR), Al-Ayed, Mohammed S.² (AUTHOR), Al-Harbi, Laila Naif¹ (AUTHOR), Yahya, Mohammed Abdo¹ (AUTHOR)

Publikováno v: Molecules. Jan2023, Vol. 28 Issue 2, p796. 17p.