M‐CSF directs myeloid and NK cell differentiation to protect from CMV after hematopoietic cell transplantation

Autor: Prashanth K Kandalla, Julien Subburayalu, Clément Cocita, Bérengère de Laval, Elena Tomasello, Johanna Iacono, Jessica Nitsche, Maria M Canali, Wilfried Cathou, Gilles Bessou, Noushin Mossadegh‐Keller, Caroline Huber, Guy Mouchiroud, Roland P Bourette, Marie‐France Grasset, Martin Bornhäuser, Sandrine Sarrazin, Marc Dalod, Michael H Sieweke

Publikováno v: EMBO Molecular Medicine, Vol 15, Iss 11, Pp 1-20 (2023)

Abstract Therapies reconstituting autologous antiviral immunocompetence may represent an important prophylaxis and treatment for immunosuppressed individuals. Following hematopoietic cell transplantation (HCT), patients are susceptible to Herpesvirid

Externí odkaz: https://doaj.org/article/09b31254506a4af3b59dd5b3a87d1220

M-CSF induces a coordinated myeloid and NK cell differentiation program protecting against CMV after hematopoietic cell transplantation

Autor: Prashanth K. Kandalla, Julien Subburayalu, Clément Cocita, Bérengère de Laval, Elena Tomasello, Johanna Iacono, Jessica Nitsche, Maria M. Canali, Wilfried Cathou, Gilles Bessou, Noushine Mossadegh-Keller, Caroline Huber, Sandrine Sarrazin, Guy Mouchiroud, Roland Bourette, Marie-France Grasset, Marc Dalod, Michael H. Sieweke

Immunosuppressed patients are highly susceptible to viral infections. Therapies reconstituting autologous antiviral immunocompetence could therefore represent an important prophylaxis and treatment. Herpesviridae including cytomegalovirus (CMV) are a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed05871a8d4d13e167ee13b7bae28070
https://doi.org/10.1101/2023.01.30.526105

Long-term culture expanded alveolar macrophages restore full epigenetic identity in vivo

Autor: Sethuraman Subramanian, Clara Busch, Kaaweh Molawi, Laufey Geirsdottir, Julien Maurizio, Stephanie Vargas-Aguilar, Hassiba Belahbib, Gregory Gimenez, Bérengère de Laval, Ridzky Yuda, Michaela Burkon, Sara Gholamhosseinian Najjar, Prashanth Kumar Kandalla, Sandrine Sarrazin, Lena Alexopoulou, Jérémy Favret, Michael Sieweke

Alveolar macrophages (AM) are tissue resident macrophages of the lung that can be expanded in culture, but it is unknown to what extent culture affects their in vivo identity. Here we show that long-term ex vivo expanded mouse AM (exAM) maintain core

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::434d6c28b8ccdece67b73020d386db31
https://doi.org/10.21203/rs.3.rs-756350/v1

Thrombopoietin protects hematopoietic stem cells from retrotransposon-mediated damage by promoting an antiviral response

Autor: Laetitia Genève, Emilie Elvira-Matelot, Stefan N. Constantinescu, Bérengère de Laval, Christian Pecquet, Gayathri Yogarajah, Daniela Barbieri, Françoise Porteu, Yanis Pelinski

Publikováno v: Journal of Experimental Medicine
Journal of Experimental Medicine, 2018, 215 (5), pp.1463-1480. ⟨10.1084/jem.20170997⟩
Journal of Experimental Medicine, Rockefeller University Press, 2018, 215 (5), pp.1463-1480. ⟨10.1084/jem.20170997⟩
The Journal of Experimental Medicine

Propagation of retrotransposons induces genomic instability. Their roles in HSCs remain poorly studied. Barbieri et al. show that retrotransposon expression and mobilization are involved in long-lasting HSC impairment upon irradiation. These effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e13c6971c8719d5add218b58577f3eea
https://hal.science/hal-02118000

Thrombopoietin-Increased DNA-PK-Dependent DNA Repair Limits Hematopoietic Stem and Progenitor Cell Mutagenesis in Response to DNA Damage

Autor: Geneviève Aubin-Houzelstein, Murielle Gaudry, Frederic Pouzoulet, Bérengère de Laval, Laurence Petit-Cocault, Michele Souyri, Patrycja Pawlikowska, Françoise Porteu, Chrystele Bilhou-Nabera

Publikováno v: Cell Stem Cell
Cell Stem Cell, 2013, 12 (1), pp.37-48. ⟨10.1016/j.stem.2012.10.012⟩

Chantier qualité GA; International audience; DNA double-strand breaks (DSBs) represent a serious threat for hematopoietic stem cells (HSCs). How cytokines and environmental signals integrate the DNA damage response and contribute to HSC-intrinsic DN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d71cab0d940961b0103ef7d90f70c1f3
https://doi.org/10.1016/j.stem.2012.10.012