Mg-based materials diminish tumor spreading and cancer metastases

Autor: Philipp Globig, Roshani Madurawala, Regine Willumeit-Römer, Fernanda Martini, Elisa Mazzoni, Bérengère J.C. Luthringer-Feyerabend

Publikováno v: Bioactive Materials, Vol 19, Iss , Pp 594-610 (2023)

Cancer metastases are the most common causes of cancer-related deaths. The formation of secondary tumors at different sites in the human body can impair multiple organ function and dramatically decrease the survival of the patients. In this stage, it

Externí odkaz: https://doaj.org/article/e2b3d977784e4227b238a3aa0e8aef4d

Controlled release of hydrogen by implantation of magnesium induces P53-mediated tumor cells apoptosis

Autor: Rui Zan, Hao Wang, Weijie Cai, Jiahua Ni, Bérengère J.C. Luthringer-Feyerabend, Wenhui Wang, Hongzhou Peng, Weiping Ji, Jun Yan, Jiazeng Xia, Yang Song, Xiaonong Zhang

Publikováno v: Bioactive Materials, Vol 9, Iss , Pp 385-396 (2022)

Hydrogen has been used to suppress tumor growth with considerable efficacy. Inhalation of hydrogen gas and oral ingestion of hydrogen-rich saline are two common systemic routes of hydrogen administration. We have developed a topical delivery method o

Externí odkaz: https://doaj.org/article/372a48ed87ef464080d516f0abed1b7b

Magnesium ions regulate mesenchymal stem cells population and osteogenic differentiation: A fuzzy agent-based modeling approach

Autor: Bérengère J.C. Luthringer-Feyerabend, Regine Willumeit-Römer, Heike Helmholz, Berit Zeller-Plumhoff, Jalil Nourisa, Vladimir Ivannikov

Publikováno v: Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 4110-4122 (2021)
Computational and Structural Biotechnology Journal
Nourisa, J.; Zeller-Plumhoff, B.; Helmholz, H.; Luthringer-Feyerabend, B.; Ivannikov, V.; Willumeit-Römer, R.: Magnesium ions regulate mesenchymal stem cells population and osteogenic differentiation: A fuzzy agent-based modeling approach. In: Computational and Structural Biotechnology Journal. Vol. 19 (2021) 4110-4122. (DOI: /10.1016/j.csbj.2021.07.005)

Graphical abstract
Mesenchymal stem cells (MSCs) are proliferative and multipotent cells that play a key role in the bone regeneration process. Empirical data have repeatedly shown the bioregulatory importance of magnesium (Mg) ions in MSC growt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c20c14d4dcc54d10d538f1f990b3b1a
http://www.sciencedirect.com/science/article/pii/S2001037021002956

Inflammatory response to magnesium-based biodegradable implant materials

Autor: Heike Helmholz, Regine Willumeit-Römer, M.D. Costantino, Bérengère J.C. Luthringer-Feyerabend, A. Meyer-Rachner, A. Schuster

Publikováno v: Acta Biomaterialia. 101:598-608

Biodegradability and mechanical properties of magnesium alloys are attractive for orthopaedic and cardiovascular applications. In order to study their cytotoxicity usually bone cells are used. However, after implantation, diverse and versatile cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::299f0dc1c3b4889790369c6c1cca1a28
https://doi.org/10.1016/j.actbio.2019.10.014

Slow degrading Mg-based materials induce tumor cell dormancy on an osteosarcoma-fibroblast coculture model

Autor: Philipp Globig, Regine Willumeit-Römer, Fernanda Martini, Elisa Mazzoni, Bérengère J.C. Luthringer-Feyerabend

Publikováno v: Globig, P.; Willumeit-Römer, R.; Martini, F.; Mazzoni, E.; Luthringer-Feyerabend, B.: Slow degrading Mg-based materials induce tumor cell dormancy on an osteosarcoma-fibroblast coculture model. In: Bioactive Materials . Vol. 16 (2022) 320-333. (DOI: /10.1016/j.bioactmat.2021.12.031)

Osteosarcoma is one of the most common cancers in young adults and is commonly treated using surgery and chemotherapy. During the past years, these therapy approaches improved but failed to ameliorate the outcomes. Therefore, novel, targeted therapeu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e8750e2324b6e859b14697b9f9037fe
https://pubmed.ncbi.nlm.nih.gov/35386318