Effects of MgSO4 Alone or Associated with 4-PBA on Behavior and White Matter Integrity in a Mouse Model of Cerebral Palsy: A Sex- and Time-Dependent Study

Autor: Lou Legouez, Bérénice Le Dieu-Lugon, Shérine Feillet, Gaëtan Riou, Melissa Yeddou, Thibault Plouchart, Nathalie Dourmap, Marie-Anne Le Ray, Stéphane Marret, Bruno J. Gonzalez, Carine Cleren

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 24, p 15947 (2022)

Cerebral palsy (CP) is defined as permanent disorders of movement and posture. Prematurity and hypoxia–ischemia (HI) are risk factors of CP, and boys display a greater vulnerability to develop CP. Magnesium sulfate (MgSO4) is administered to mother

Externí odkaz: https://doaj.org/article/dd0c046758ba408aa6a2b5b4d0270f8c

Hypoxia-Ischemia Induced Age-Dependent Gene Transcription Effects at Two Development Stages in the Neonate Mouse Brain

Autor: Nicolas Dupré, Céline Derambure, Bérénice Le Dieu-Lugon, Michelle Hauchecorne, Yannick Detroussel, Bruno J. Gonzalez, Stéphane Marret, Philippe Leroux

Publikováno v: Frontiers in Molecular Neuroscience, Vol 13 (2020)

Human brain lesions in the perinatal period result in life-long neuro-disabilities impairing sensory-motor, cognitive, and behavior functions for years. Topographical aspects of brain lesions depend on gestational age at the time of insult in preterm

Externí odkaz: https://doaj.org/article/df1a08da18f74edfbf8fcf6a6e76c02a

Effects of MgSO

Autor: Lou, Legouez, Bérénice, Le Dieu-Lugon, Shérine, Feillet, Gaëtan, Riou, Melissa, Yeddou, Thibault, Plouchart, Nathalie, Dourmap, Marie-Anne, Le Ray, Stéphane, Marret, Bruno J, Gonzalez, Carine, Cleren

Publikováno v: International journal of molecular sciences. 23(24)

Cerebral palsy (CP) is defined as permanent disorders of movement and posture. Prematurity and hypoxia-ischemia (HI) are risk factors of CP, and boys display a greater vulnerability to develop CP. Magnesium sulfate (MgSO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6327568a7c490e78fc6c3ffc88edbcf7
https://pubmed.ncbi.nlm.nih.gov/36555591

Why considering sexual differences is necessary when studying encephalopathy of prematurity through rodent models

Autor: Bérénice Le Dieu-Lugon, Isabelle Leroux-Nicollet, Lou Legouez, Stéphane Marret, Philippe Leroux, Nicolas Dupré, Bruno J. Gonzalez, Carine Cleren

Publikováno v: European Journal of Neuroscience
European Journal of Neuroscience, Wiley, 2019, ⟨10.1111/ejn.14664⟩

Preterm birth is a high-risk factor for the development of gray and white matter abnormalities, referred to as "encephalopathy of prematurity," that may lead to life-long motor, cognitive, and behavioral impairments. The prevalence and clinical outco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c36b8d1d8357360adc75564476fda20b
https://pubmed.ncbi.nlm.nih.gov/31885096

Magnesium Sulfate Prevents Neurochemical and Long-Term Behavioral Consequences of Neonatal Excitotoxic Lesions: Comparison Between Male and Female Mice

Autor: Lauriane Ramet, Cathy Gomila, Bruno J. Gonzalez, Jérôme Ausseil, Philippe Leroux, Ismaël Daher, Bérénice Le Dieu-Lugon, Vincent Roy, Isabelle Leroux-Nicollet, Matthieu Jean Alexandre Lecuyer, Nathalie Dourmap, Salah El Mestikawy, Stéphanie Daumas, Stéphane Marret, Carine Cleren

Publikováno v: Journal of Neuropathology and Experimental Neurology
Journal of Neuropathology and Experimental Neurology, Lippincott, Williams & Wilkins, 2017, 76 (10), pp.883-897. ⟨10.1093/jnen/nlx073⟩
Journal of Neuropathology and Experimental Neurology, 2017, 76 (10), pp.883-897. ⟨10.1093/jnen/nlx073⟩
BASE-Bielefeld Academic Search Engine

Magnesium sulfate (MgSO4) administration to mothers at risk of preterm delivery is proposed as a neuroprotective strategy against neurological alterations such as cerebral palsy in newborns. However, long-term beneficial or adverse effects of MgSO4 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00cf2d138cf164645073bcb97f6b7d44
https://hal.archives-ouvertes.fr/hal-01662388