Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Bérénice Charrez"'
Autor:
Bérénice Charrez, Verena Charwat, Brian Siemons, Henrik Finsberg, Evan W. Miller, Andrew G. Edwards, Kevin E. Healy
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 3, Pp 1155-1165 (2021)
Abstract Only a handful of US Food and Drug Administration (FDA) Emergency Use Authorizations exist for drug and biologic therapeutics that treat severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) infection. Potential therapeutics inc
Externí odkaz:
https://doaj.org/article/909a322bfea042109b6b1af1e914fe94
Autor:
Bérénice Charrez, Verena Charwat, Brian A. Siemons, Ishan Goswami, Courtney Sakolish, Yu-Syuan Luo, Henrik Finsberg, Andrew G. Edwards, Evan W. Miller, Ivan Rusyn, Kevin E. Healy
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Despite global efforts, it took 7 months between the proclamation of global SARS-CoV-2 pandemic and the first FDA-approved treatment for COVID-19. During this timeframe, clinicians focused their efforts on repurposing drugs, such as hydroxychloroquin
Externí odkaz:
https://doaj.org/article/24b7f9e303f54de4a211eb7cf95a932a
Autor:
Karoline Horgmo Jæger, Verena Charwat, Bérénice Charrez, Henrik Finsberg, Mary M. Maleckar, Samuel Wall, Kevin E. Healy, Aslak Tveito
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2020)
Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) hold great potential for drug screening applications. However, their usefulness is limited by the relative immaturity of the cells’ electrophysiological properties as comp
Externí odkaz:
https://doaj.org/article/27f371634cb1449b8021351a68f2a484
Autor:
Verena Charwat, Bérénice Charrez, Brian A. Siemons, Henrik Finsberg, Karoline H. Jæger, Andrew G. Edwards, Nathaniel Huebsch, Samuel Wall, Evan Miller, Aslak Tveito, Kevin E. Healy
Publikováno v:
ACS pharmacologytranslational science. 5(8)
Evaluation of arrhythmogenic drugs is required by regulatory agencies before any new compound can obtain market approval. Despite rigorous review, cardiac disorders remain the second most common cause for safety-related market withdrawal. On the othe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08898411e27bad5bd0f3afd54a587b5d
https://pubmed.ncbi.nlm.nih.gov/35983280
https://pubmed.ncbi.nlm.nih.gov/35983280
Autor:
Megan M Sperry, Berenice Charrez, Haleh Fotowat, Erica Gardner, Kanoelani Pilobello, Zohreh Izadifar, Tiffany Lin, Abigail Kuelker, Sahith Kaki, Michael Lewandowski, Shanda Lightbown, Ramses Martinez, Susan Marquez, Joel Moore, Maria Plaza-Oliver, Adama M Sesay, Kostyantyn Shcherbina, Katherine Sheehan, Takako Takeda, Daniela Del Campo, Kristina Andrijauskaite, Exal Cisneros, Riley Lopez, Isabella Cano, Zachary Maxwell, Israel Jessop, Rafa Veraza, Leon Bunegin, Thomas J Percival, Jaclyn Yracheta, Jorge J Pena, Diandra M Wood, Zachary T Homas, Cody J Hinshaw, Jennifer Cox-Hinshaw, Olivia G Parry, Justin J Sleeter, Erik K Weitzel, Michael Levin, Michael Super, Richard Novak, Donald E Ingber
Publikováno v:
eLife, Vol 13 (2024)
Drugs that induce reversible slowing of metabolic and physiological processes would have great value for organ preservation, especially for organs with high susceptibility to hypoxia-reperfusion injury, such as the heart. Using whole-organism screeni
Externí odkaz:
https://doaj.org/article/095738c148254bf3aca1f94a4c99d2bb
Autor:
Alison Fanton, Arturo M. Escajeda, Qi Dang, Sarah A. Stanley, Scott B. Biering, Jennifer A. Doudna, Maria Lukarska, David F. Savage, Shreeya Agrawal, Sita S. Chandrasekaran, Tina Y. Liu, Shin Kim, Dylan C. J. Smock, Gavin J. Knott, Ming X. Tan, Eli J Dugan, Eva Harris, Maxim Armstrong, María Díaz de León Derby, Patrick D. Hsu, Bérénice Charrez, Abdul Bhuiya, Daniel A. Fletcher, Noam Prywes, Andrew R. Harris, Roger McIntosh, Neil A. Switz, Sungmin Son, Amanda Mok, Erik Van Dis, Liana F. Lareau
SummaryRapid nucleic acid testing is a critical component of a robust infrastructure for increased disease surveillance. Here, we report a microfluidic platform for point-of-care, CRISPR-based molecular diagnostics. We first developed a nucleic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e1f77d8169d1823e572832e48428314
https://doi.org/10.1101/2020.12.14.20247874
https://doi.org/10.1101/2020.12.14.20247874
Autor:
Sita S, Chandrasekaran, Shreeya, Agrawal, Alison, Fanton, Aditya R, Jangid, Bérénice, Charrez, Arturo M, Escajeda, Sungmin, Son, Roger, Mcintosh, Huyen, Tran, Abdul, Bhuiya, María Díaz, de León Derby, Neil A, Switz, Maxim, Armstrong, Andrew R, Harris, Noam, Prywes, Maria, Lukarska, Scott B, Biering, Dylan C J, Smock, Amanda, Mok, Gavin J, Knott, Qi, Dang, Erik, Van Dis, Eli, Dugan, Shin, Kim, Tina Y, Liu, Erica A, Moehle, Katherine, Kogut, Brenda, Eskenazi, Eva, Harris, Sarah A, Stanley, Liana F, Lareau, Ming X, Tan, Daniel A, Fletcher, Jennifer A, Doudna, David F, Savage, Alisha, Baldwin
Publikováno v:
Nature biomedical engineering. 6(8)
Rapid nucleic acid testing is central to infectious disease surveillance. Here, we report an assay for rapid COVID-19 testing and its implementation in a prototype microfluidic device. The assay, which we named DISCoVER (for diagnostics with coronavi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::00c2f7d800c01ee74ace68eaf9a0d410
https://pubmed.ncbi.nlm.nih.gov/35986182
https://pubmed.ncbi.nlm.nih.gov/35986182
Autor:
Lionel Hebbard, Jade Sternberg, Prithi S. Bhathal, Liang Qiao, Scott A. Read, Bérénice Charrez, Carol Devine, Jacob George, Miriam Wankell, Golo Ahlensteil, Andreas L. Lopata, Stephanie Obeid, Saeed Esmaili, Mehdi Ramezani-Moghadam, Roxane Kreuter
Adiponectin demonstrates beneficial effects in various metabolic diseases, including diabetes, and in bowel cancer. Recent data also suggest a protective role in colitis. However, the precise molecular mechanisms by which adiponectin and its receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c36ea2d757c2b6822aa8091b2b1cd7b9
https://europepmc.org/articles/PMC5399108/
https://europepmc.org/articles/PMC5399108/
Hepatocellular carcinoma (HCC) is now the fifth cancer of greatest frequency and the second leading cause of cancer related deaths worldwide. Chief amongst the risks of HCC are hepatitis B and C infection, aflatoxin B1 ingestion, alcoholism and obesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e79ca249a0f249f91d0604f9aaa59064
https://europepmc.org/articles/PMC4768195/
https://europepmc.org/articles/PMC4768195/
Publikováno v:
Hormone molecular biology and clinical investigation. 22(2)
Fructose consumption has dramatically increased in the last 30 years. The principal form has been in the form of high-fructose corn syrup found in soft drinks and processed food. The effect of excessive fructose consumption on human health is only be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b80c3d9e2e48fdfb7b5ce97a23cfd6
https://pubmed.ncbi.nlm.nih.gov/25965509
https://pubmed.ncbi.nlm.nih.gov/25965509