Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Bérénice C. Lemercier"'
Publikováno v:
Synlett. 27:181-189
Thiohydroximic acids are a heteroatom-rich class of compounds that have long been used only as a means to study the biology of their glucosinolate subclass. However, due to their wide range of reactivity and surprising stability, they have recently e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8223c7d2a7ef71821da35c051435abc2
https://doi.org/10.1055/s-0035-1560700
https://doi.org/10.1055/s-0035-1560700
Autor:
Nadine F. Joseph, Wen-Ning Zhao, Patrick McCarren, Taner Kaya, Daniel M. Fass, Surya A. Reis, Jennifer P. Gale, K. M. Hennig, Florence F. Wagner, Ji-Song Guan, Méryl Thomas, Michael C. Lewis, Stephen J. Haggarty, Stewart L. Fisher, Edward B. Holson, M. P. Moyer, Edward M. Scolnick, Bérénice C. Lemercier, Michel Weïwer, Yan Ling Zhang, Li-Huei Tsai
Publikováno v:
Chemical Science. 6:804-815
Aiming towards the development of novel nootropic therapeutics to address the cognitive impairment common to a range of brain disorders, we set out to develop highly selective small molecule inhibitors of HDAC2, a chromatin modifying histone deacetyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fe2ee912b420295cf85c3d1fc181714
https://doi.org/10.1039/c4sc02130d
https://doi.org/10.1039/c4sc02130d
Publikováno v:
The Journal of organic chemistry. 83(1)
An efficient synthesis of S-allyl thioimidate hydrobromide salts via coupling of thioamides with allyl bromide derivatives is described. A range of mono-, di-, and trisubstituted olefins as well as alkyl- and arylthioamides with variations in electro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85715c011102e9239cd5adfdc3eae2e4
https://pubmed.ncbi.nlm.nih.gov/29064693
https://pubmed.ncbi.nlm.nih.gov/29064693
Publikováno v:
The Journal of Organic Chemistry. 79:2321-2330
An improved and expanded preparation of thiohydroxamic acids is reported along with a one-pot conversion of these compounds to novel thiohydroximic acid derivatives. A variety of aryl, heteroaryl, and alkyl substituents are well tolerated to provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::263f66190c41aa23723189718ff9a308
https://doi.org/10.1021/jo500080x
https://doi.org/10.1021/jo500080x
Publikováno v:
ChemInform. 47
Thiohydroximic acids are a heteroatom-rich class of compounds that have long been used only as a means to study the biology of their glucosinolate subclass. However, due to their wide range of reactivity and surprising stability, they have recently e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6aad1dbbbce323ec4465154b69183c41
https://doi.org/10.1002/chin.201614227
https://doi.org/10.1002/chin.201614227
Publikováno v:
ChemInform. 47
An oxidative formation of 1,4,2-oxathiazoles from readily available thiohydroximic acids is reported. A variety of alkyl, aryl, and heteroaryl substituents are well tolerated for both the thiohydroximic acid and activating fragments, and the reaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e2a8102af1c538d55f346d551aac728
https://doi.org/10.1002/chin.201605154
https://doi.org/10.1002/chin.201605154
Autor:
Carol A. Mulrooney, Morgan Welzel-O’Shea, Bérénice C. Lemercier, Edward B. Holson, Landon Durak, Sarathy Kesavan, Jeremy R. Duvall, Jingqiang Wei, Florence F. Wagner, Adrien Joliton, Laura M. Panko, Maurice D. Lee, Lisa A. Marcaurelle, Lakshmi B. Akella, Haibo Liu, Emeline L. Davoine, Jason T. Lowe, Méryl Thomas, Etienne J. Donckele, Michael Foley, Byung-Chul Suh, Giovanni Muncipinto, Ann Rowley, Jean-Charles Marie, Baudouin Gerard
Publikováno v:
The Journal of Organic Chemistry. 77:7187-7211
The synthesis and diversification of a densely functionalized azetidine ring system to gain access to a wide variety of fused, bridged, and spirocyclic ring systems is described. The in vitro physicochemical and pharmacokinetic properties of represen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8203c3d71af27e48bd78615da92d79b3
https://doi.org/10.1021/jo300974j
https://doi.org/10.1021/jo300974j
Publikováno v:
ChemInform. 45
A copper catalyzed aminobromination of alkene tethered thiohydroximic acids is described, providing a rapid approach to unnatural thiazoline scaffolds not readily available via existing methods. Moderate to high yields of bromothiazolines are obtaine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e6df14bc230e46a587ddb63d2277aad
https://doi.org/10.1002/chin.201438130
https://doi.org/10.1002/chin.201438130
Publikováno v:
ChemInform. 45
The conversion of the thiohydroxamic acids (II) to their derivatives via allylation and acylation can be performed in a one-pot manner [cf.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e240dde6ada33c7127d37776013b4d4a
https://doi.org/10.1002/chin.201432065
https://doi.org/10.1002/chin.201432065
Publikováno v:
Organic letters. 16(7)
A copper catalyzed aminobromination of alkene tethered thiohydroximic acids is described, providing a rapid approach to unnatural thiazoline scaffolds not readily available via existing methods. Moderate to high yields of bromothiazolines are obtaine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c849c82fe664ed24885d18926ca9af
https://pubmed.ncbi.nlm.nih.gov/24645640
https://pubmed.ncbi.nlm.nih.gov/24645640