Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Bénédicte Van Maele"'
Autor:
Bénédicte Van Maele, Chris Van den Haute, Zeger Debyser, Myriam Witvrouw, Rik Gijsbers, Linos Vandekerckhove, Jan De Rijck, Frauke Christ
Publikováno v:
Journal of Virology. 80:1886-1896
After identifying the interaction between the transcriptional coactivator lens epithelium-derived growth factor (LEDGF/p75) and the human immunodeficiency virus type 1 (HIV-1) integrase (IN), we have now investigated the role of LEDGF/p75 during HIV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58ea3da355197cad7e18d7a66d72e07b
https://doi.org/10.1128/jvi.80.4.1886-1896.2006
https://doi.org/10.1128/jvi.80.4.1886-1896.2006
Publikováno v:
Biochemical and Biophysical Research Communications. 327:261-267
Since the integration of viral DNA in the host genome is an essential step in the replication cycle of HIV-1, an active search for inhibitors of the integration step is ongoing. Our laboratory has been working on the development of a cellular integra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::028af49a664f23c20941778e6f02175e
https://doi.org/10.1016/j.bbrc.2004.11.157
https://doi.org/10.1016/j.bbrc.2004.11.157
Autor:
Laura De Luca, Bénédicte Van Maele, Alba Chimirri, Zeger Debyser, Maria Letizia Barreca, Myriam Witvrouw, P. Monforte, M. Zappala, Cristina Gurnari, James M. Briggs, Angela Rao, Erik De Clercq
Publikováno v:
Journal of Chemical Information and Computer Sciences. 44:1450-1455
We describe the use of pharmacophore modeling as an efficient tool in the discovery of novel HIV-1 integrase (IN) inhibitors. A three-dimensional hypothetical model for the binding of diketo acid analogues to the enzyme was built by means of the Cata
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e99eda7e9e40578f0e19089921639ef6
https://doi.org/10.1021/ci034296e
https://doi.org/10.1021/ci034296e
Autor:
Bénédicte Van Maele, Myriam Witvrouw, Valery Fikkert, Erik De Clercq, Godwin Pais, Nouri Neamati, Terrence R. Burke, W Pluymers, Zeger Debyser, Christophe Pannecouque
Publikováno v:
Antimicrobial Agents and Chemotherapy. 46:3292-3297
A series of diketo derivatives was found to inhibit human immunodeficiency virus type 1 (HIV-1) integrase activity. Only L-708,906 inhibited the replication of HIV-1(III B ) (50% effective concentration, 12 μM), HIV-1 clinical strains, HIV-1 strains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cdd387777682cc698aa578fd3a612c7
https://doi.org/10.1128/aac.46.10.3292-3297.2002
https://doi.org/10.1128/aac.46.10.3292-3297.2002
Autor:
Christophe Pannecouque, W Pluymers, Erik De Clercq, Myriam Witvrouw, Peter Cherepanov, Zeger Debyser, Bénédicte Van Maele, Victor Tetz
Publikováno v:
Current Biology. 12:1169-1177
Background: To improve the existing combination therapies of infection with the human immunodeficiency virus (HIV) and to cope with virus strains that are resistant to multiple drugs, we initiated a search for effective inhibitors of HIV integrase, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b71ad49b09ecd3bf23ec1f4079a83ca8
https://doi.org/10.1016/s0960-9822(02)00952-1
https://doi.org/10.1016/s0960-9822(02)00952-1
Publikováno v:
Trends in biochemical sciences. 31(2)
To achieve productive infection, the reverse transcribed cDNA of human immunodeficiency virus type 1 (HIV-1) is inserted in the host cell genome. The main protein responsible for this reaction is the viral integrase. However, studies indicate that th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c69a636e51a298288f4e80de144f401
https://pubmed.ncbi.nlm.nih.gov/16403635
https://pubmed.ncbi.nlm.nih.gov/16403635
Autor:
Myriam Witvrouw, Denis Tempé, Jean-Christophe Rain, Aurelie Mousnier, Lilia Ben-Slama, Katrien Busschots, Zeger Debyser, Catherine Dargemont, Fanny Moisant, Richard Benarous, Frauke Christ, Marlène Maroun, Bénédicte Van Maele, Linos Vandekerckhove, Stéphane Emiliani
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2005, 280 (27), pp.25517-25523. ⟨10.1074/jbc.M501378200⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2005, 280 (27), pp.25517-25523. ⟨10.1074/jbc.M501378200⟩
The insertion of a DNA copy of its RNA genome into a chromosome of the host cell is mediated by the viral integrase with the help of mostly uncharacterized cellular cofactors. We have recently described that the transcriptional co-activator LEDGF/p75
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3827db7dc946ab66e0c95673b143f8b9
https://hal.archives-ouvertes.fr/hal-03470854
https://hal.archives-ouvertes.fr/hal-03470854
Autor:
Bénédicte, Van Maele, Zeger, Debyser
Publikováno v:
AIDS reviews. 7(1)
To achieve a productive infection, the reverse transcribed cDNA of the human immunodeficiency virus type 1 (HIV-1) has to be inserted in the host cell genome. The main protein required to accomplish this reaction is the virally encoded integrase. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3747b53c083a7adbd3ed8f2927c53596
https://pubmed.ncbi.nlm.nih.gov/15875659
https://pubmed.ncbi.nlm.nih.gov/15875659
Publikováno v:
Biochemical and biophysical research communications. 328(4)
During reverse transcription of the human immunodeficiency virus type 1 (HIV-1), a 90- or 99-nucleotide long DNA flap is formed at the centre of the viral cDNA. The presence of a central DNA flap in lentiviral vectors improves transduction efficiency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc762def29d1554c5f09bd247f8b456
https://pubmed.ncbi.nlm.nih.gov/15707975
https://pubmed.ncbi.nlm.nih.gov/15707975
Autor:
Christophe Pannecouque, Jo Vercammen, Martine Michiels, Valery Fikkert, Anke Hantson, Marc De Maeyer, Yves Engelborghs, Myriam Witvrouw, Cristina Gurnari, Bénédicte Van Maele, Erik De Clercq, Zeger Debyser, Barbara Van Remoortel
The diketo acid L-708,906 has been reported to be a selective inhibitor of the strand transfer step of the human immunodeficiency virus type 1 (HIV-1) integration process (D. Hazuda, P. Felock, M. Witmer, A. Wolfe, K. Stillmock, J. A. Grobler, A. Esp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a4d78c3880a8d4d5cf959716f598dc0
https://europepmc.org/articles/PMC229256/
https://europepmc.org/articles/PMC229256/