Cationic Oligonucleotide−Peptide Conjugates with Aggregating Properties Enter Efficiently into Cells while Maintaining Hybridization Properties and Enzymatic Recognition

Autor: Gérard Nullans, Jean-Paul Behr, Guy Zuber, Bénédicte Pons, Andrew W. Fraley, Deniz Dalkara

Publikováno v: Journal of the American Chemical Society. 128:10763-10771

Oligonucleotide delivery is a crucial issue for therapeutical purposes and is often addressed by conjugation to short cationic peptides although with controversial results. To further examine this mechanism, a 15-mer anionic oligonucleotide was conju

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43fa3b134d941e6c9dfa5a80b8a48987
https://doi.org/10.1021/ja060873e

Oligonucleotide-oligospermine conjugates (zip nucleic acids): a convenient means of finely tuning hybridization temperatures

Autor: Mitsuharu Kotera, Bénédicte Pons, Régis Noir, Jean-Paul Behr, Jean-Serge Remy

Publikováno v: Journal of the American Chemical Society
Journal of the American Chemical Society, American Chemical Society, 2008, 130 (40), pp.13500-13505. ⟨10.1021/ja804727a⟩

Synthesis of oligonucleotide probes and control of their hybridization temperature are key aspects of polymerase chain reaction (PCR)-based detection of genetic sequences. A straightforward means to approach the last goal is to decrease the repulsion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cfc3653348a6be1477d541cf8a0d7d6
https://pubmed.ncbi.nlm.nih.gov/18781743

omega-Hydrazino linear polyethylenimine: a monoconjugation building block for nucleic acid delivery

Autor: Przemyslaw Godzina, Jean-Paul Behr, Abdennaji Adib, Lila Mouhoubi, Guy Zuber, Bénédicte Pons

Publikováno v: Chembiochem : a European journal of chemical biology. 7(2)

Nonviral gene therapy requires efficient vectors that are able to deliver nucleic acids inside the targeted cell nucleus. Developing new tools for the synthesis of supramolecular vectors with improved transfection efficiency and better biodistributio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91037c02431c5df2ef42679ee26c0e50
https://pubmed.ncbi.nlm.nih.gov/16416489

Synthesis and X-ray crystal structure of [2(phosphinomethyl)ferrocenyl]diphenyl-phosphine

Autor: Angela Marinetti, Francis Labrue, Louis Ricard, Bénédicte Pons

Publikováno v: Journal of Organometallic Chemistry
Journal of Organometallic Chemistry, Elsevier, 2005, 690, pp.2285-2290. ⟨10.1016/j.jorganchem.2005.02.034⟩
Journal of Organometallic Chemistry, Elsevier, 2005, 690(9), pp.2285-2290. ⟨10.1016/j.jorganchem.2005.02.034⟩

[2-(Phosphinomethyl)ferrocenyl]diphenylphosphine 2, is an air stable primary phosphine bearing a 1,2-disubstituted ferrocene framework, which has been prepared by reduction of the corresponding phosphonate. Confirmation of its structure has been obta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::475d3eb28fed62ffec0faf2a800f327f
https://hal.archives-ouvertes.fr/hal-00114278/file/Ferrocene.pdf

Dysfunctional BTN3A together with deregulated immune checkpoints and type I/II IFN dictate defective interplay between pDCs and γδ T cells in melanoma patients, which impacts clinical outcomes

Autor: Pauline Girard, Eleonora Sosa Cuevas, Benedicte Ponsard, Stephane Mouret, Hugo Gil, Edwige Col, Florence De Fraipont, Nathalie Sturm, Julie Charles, Olivier Manches, Laurence Chaperot, Caroline Aspord

Publikováno v: Clinical & Translational Immunology, Vol 10, Iss 11, Pp n/a-n/a (2021)

Abstract Objectives pDCs and γδ T cells emerge as potent immune players participating in the pathophysiology of cancers, yet still remaining enigmatic while harbouring a promising potential for clinical translations. Despite strategic and closed mi

Externí odkaz: https://doaj.org/article/cd84e9bba19f4244a20d06c6ed117e9c