Intron retention in mRNA encoding ancillary subunit of insect voltage-gated sodium channel modulates channel expression, gating regulation and drug sensitivity

Autor: Marjorie Juchaux, Ke Dong, Lingxin Wang, Nathalie C. Guérineau, Sophie Quinchard, Bruno Lapied, Laurence Murillo, Céline Bourdin, Christian Legros, Bénédicte Moignot

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2013, 8 (8), pp.e67290. ⟨10.1371/journal.pone.0067290⟩
PLoS ONE, Vol 8, Iss 8, p e67290 (2013)
Plos One 8 (8), e67290. (2013)

Insect voltage-gated sodium (Nav) channels are formed by a well-known pore-forming α-subunit encoded by para-like gene and ancillary subunits related to TipE from the mutation "temperature-induced-paralysis locus E." The role of these ancillary subu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51cb4fb249e7e8a974e159bacb2158e1
https://hal.archives-ouvertes.fr/hal-01190533/document

How does calcium-dependent intracellular regulation of voltage-dependent sodium current increase the sensitivity to the oxadiazine insecticide indoxacarb metabolite decarbomethoxylated JW062 (DCJW) in insect pacemaker neurons

Autor: Christian Legros, Bruno Lapied, Bénédicte Moignot, Céline Lavialle-Defaix

Publikováno v: Journal of Pharmacology and Experimental Therapeutics
Journal of Pharmacology and Experimental Therapeutics, 2010, 333 (1), pp.264-272. ⟨10.1124/jpet.109.163519⟩

International audience; Decarbomethoxylated JW062 (DCJW), the active component of the oxadiazine insecticide (S)-methyl 7-chloro-2,5-dihydro-2-[[(methoxycarbonyl)[4-(trifluoromethoxy)phenyl] amino]carbonyl] indeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carbo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8050bb3c34b8cdfdb11d26bc0ffe3fdf
https://hal.univ-angers.fr/hal-03405658