The claudin-like apicomplexan microneme protein is required for gliding motility and infectivity of Plasmodium sporozoites.

Autor: Manon Loubens, Carine Marinach, Clara-Eva Paquereau, Soumia Hamada, Bénédicte Hoareau-Coudert, David Akbar, Jean-François Franetich, Olivier Silvie

Publikováno v: PLoS Pathogens, Vol 19, Iss 3, p e1011261 (2023)

Invasion of host cells by apicomplexan parasites such as Toxoplasma and Plasmodium spp requires the sequential secretion of the parasite apical organelles, the micronemes and the rhoptries. The claudin-like apicomplexan microneme protein (CLAMP) is a

Externí odkaz: https://doaj.org/article/1926ed2b342e4f58a1d86fc22a73057f

Platelet‐Derived Growth Factor Receptor Type α Activation Drives Pulmonary Vascular Remodeling Via Progenitor Cell Proliferation and Induces Pulmonary Hypertension

Autor: Julien Solinc, Jessica Raimbault‐Machado, France Dierick, Lamiaa El Bernoussi, Ly Tu, Raphaël Thuillet, Nathalie Mougenot, Bénédicte Hoareau‐Coudert, Virginie Monceau, Catherine Pavoine, Fabrice Atassi, David Sassoon, Giovanna Marazzi, Richard P. Harvey, Peter Schofield, Daniel Christ, Marc Humbert, Christophe Guignabert, Florent Soubrier, Sophie Nadaud

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 7 (2022)

Background Platelet‐derived growth factor is a major regulator of the vascular remodeling associated with pulmonary arterial hypertension. We previously showed that protein widely 1 (PW1+) vascular progenitor cells participate in early vessel neomu

Externí odkaz: https://doaj.org/article/81cbbe521b80430db80a86d9c5326839

The dimerisable Cre recombinase allows conditional genome editing in the mosquito stages of Plasmodium berghei.

Autor: Priyanka Fernandes, Sylvie Briquet, Delphine Patarot, Manon Loubens, Bénédicte Hoareau-Coudert, Olivier Silvie

Publikováno v: PLoS ONE, Vol 15, Iss 10, p e0236616 (2020)

Asexual blood stages of the malaria parasite are readily amenable to genetic modification via homologous recombination, allowing functional studies of parasite genes that are not essential in this part of the life cycle. However, conventional reverse

Externí odkaz: https://doaj.org/article/4e7576dfd16f4a61a8ed31c986a9f261

Naive and memory CD4

Autor: Raphaël, Jeger-Madiot, Romain, Vaineau, Maud, Heredia, Nicolas, Tchitchek, Lisa, Bertrand, Mathias, Pereira, Océane, Konza, Bruno, Gouritin, Bénédicte, Hoareau-Coudert, Aurélien, Corneau, Catherine, Blanc, Eric, Savier, Pierre, Buffet, Adrien, Six, David, Klatzmann, Arnaud, Moris, Stéphanie, Graff-Dubois

Publikováno v: iScience

Summary CD4+ T follicular helper cells (Tfh) promote B cell maturation and antibody production in secondary lymphoid organs. By using an innovative culture system based on splenocyte stimulation, we studied the dynamics of naive and memory CD4+ T cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e47f06e080d2c400040c9b8667c37a02
https://pubmed.ncbi.nlm.nih.gov/34984326

Resident PW1 + Progenitor Cells Participate in Vascular Remodeling During Pulmonary Arterial Hypertension

Autor: France Dierick, Tiphaine Héry, Bénédicte Hoareau-Coudert, Nathalie Mougenot, Virginie Monceau, Caroline Claude, Mihaela Crisan, Vanessa Besson, Peter Dorfmüller, Gilles Marodon, Elie Fadel, Marc Humbert, Elisa Yaniz-Galende, Jean-Sébastien Hulot, Giovanna Marazzi, David Sassoon, Florent Soubrier, Sophie Nadaud

Publikováno v: Circulation Research
Circulation Research, American Heart Association, 2016, 118 (5), pp.822-833 ⟨10.1161/CIRCRESAHA.115.307035⟩
Circulation Research, 2016, 118 (5), pp.822-833 ⟨10.1161/CIRCRESAHA.115.307035⟩
Circulation Research, 118(5), 822-833. Lippincott Williams & Wilkins

Rationale: Pulmonary arterial hypertension is characterized by vascular remodeling and neomuscularization. PW1 + progenitor cells can differentiate into smooth muscle cells (SMCs) in vitro. Objective: To determine the role of pulmonary PW1 + progenit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4713b8a5570ed3bb7a63b3bb14fe815e
https://doi.org/10.1161/circresaha.115.307035