Výsledky vyhledávání - "Béla, Gyurcsik"

Akademický článek

Circular Dichroism Spectroscopic Studies on Solution Chemistry of M(II)-Monensinates in Their Competition Reactions

Autor: Máté Levente Kis, Bálint Hajdu, Petar Dorkov, Ivayla Pantcheva, Béla Gyurcsik

Publikováno v: Inorganics, Vol 11, Iss 8, p 334 (2023)

The chirality of the polyether ionophore monensic acid A can be successfully used to study its coordination ability in solution. A complementary approach to gain new insights into the complexation chemistry of the antibiotic (studied previously by ci

Externí odkaz: https://doaj.org/article/c45e57f04a5b45668bb358c41bd2ef81

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Akademický článek

Hydrolytic Mechanism of a Metalloenzyme Is Modified by the Nature of the Coordinated Metal Ion

Autor: Zeyad H. Nafaee, Bálint Hajdu, Éva Hunyadi-Gulyás, Béla Gyurcsik

Publikováno v: Molecules, Vol 28, Iss 14, p 5511 (2023)

The nuclease domain of colicin E7 cleaves double-strand DNA non-specifically. Zn2+ ion was shown to be coordinated by the purified NColE7 as its native metal ion. Here, we study the structural and catalytic aspects of the interaction with Ni2+, Cu2+

Externí odkaz: https://doaj.org/article/6fb3678e14a746ac91e45d087c0e3d56

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Akademický článek

Interactions of an Artificial Zinc Finger Protein with Cd(II) and Hg(II): Competition and Metal and DNA Binding

Autor: Bálint Hajdu, Éva Hunyadi-Gulyás, Béla Gyurcsik

Publikováno v: Inorganics, Vol 11, Iss 2, p 64 (2023)

Cys2His2 zinc finger proteins are important for living organisms, as they—among other functions—specifically recognise DNA when Zn(II) is coordinated to the proteins, stabilising their ββα secondary structure. Therefore, competition with other

Externí odkaz: https://doaj.org/article/62aa7cedfbc74730a1674b05577b0c1d

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Akademický článek

Estradiol-Based Salicylaldehyde (Thio)Semicarbazones and Their Copper Complexes with Anticancer, Antibacterial and Antioxidant Activities

Autor: Tatsiana V. Petrasheuskaya, Ferenc Kovács, Nóra Igaz, Andrea Rónavári, Bálint Hajdu, Laura Bereczki, Nóra V. May, Gabriella Spengler, Béla Gyurcsik, Mónika Kiricsi, Éva Frank, Éva A. Enyedy

Publikováno v: Molecules, Vol 28, Iss 1, p 54 (2022)

A series of novel estradiol-based salicylaldehyde (thio)semicarbazones ((T)SCs) bearing (O,N,S) and (O,N,O) donor sets and their Cu(II) complexes were developed and characterized in detail by 1H and ¹³C nuclear magnetic resonance spectroscopy, UV�

Externí odkaz: https://doaj.org/article/8955a198063c498eaca85577a98baf1a

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Temoneira-1 β-lactamase is not a metalloenzyme, but its native metal ion binding sites allow for purification by immobilized metal ion affinity chromatography

Autor: Zeyad H. Nafaee, Éva Hunyadi-Gulyás, Béla Gyurcsik

Publikováno v: Protein expression and purification. 201

β-lactamases protect bacteria from β-lactam antibiotics. Temoneira (TEM) is a class A serine β-lactamase and its coding sequence is designed into DNA vectors, such as pET-21a (+), to provide antibiotic resistance. TEM-1 β-lactamase was overexpres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1cd8519d1a731d9b6fcdea8dd5b75e4
https://pubmed.ncbi.nlm.nih.gov/36115639

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Tying Up a Loose End:On the Role of the C-Terminal CCHHRAG Fragment of the Metalloregulator CueR

Autor: Ria K. Balogh, Béla Gyurcsik, Mikael Jensen, Peter W. Thulstrup, Ulli Köster, Niels Johan Christensen, Marianne L. Jensen, Éva Hunyadi‐Gulyás, Lars Hemmingsen, Attila Jancsó

Publikováno v: Balogh, R K, Gyurcsik, B, Jensen, M, Thulstrup, P W, Köster, U, Christensen, N J, Jensen, M L, Hunyadi-Gulyás, É, Hemmingsen, L & Jancsó, A 2022, ' Tying Up a Loose End : On the Role of the C-Terminal CCHHRAG Fragment of the Metalloregulator CueR ', ChemBioChem, vol. 23, no. 16, e202200290 . https://doi.org/10.1002/cbic.202200290
Balogh, R K, Gyurcsik, B, Jensen, M, Thulstrup, P W, Koester, U, Christensen, N J, Jensen, M L, Hunyadi-Gulyas, E, Hemmingsen, L & Jancso, A 2022, ' Tying Up a Loose End : On the Role of the C-Terminal CCHHRAG Fragment of the Metalloregulator CueR ', ChemBioChem, vol. 23, no. 16, 202200290 . https://doi.org/10.1002/cbic.202200290

The transcriptional regulator CueR is activated by the binding of CuI, AgI, or AuI to two cysteinates in a near-linear fashion. The C-terminal CCHHRAG sequence in Escherichia coli CueR present potential additional metal binding ligands and here we ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e6e74408ddfdb1383338cefccbfcb8c
https://orbit.dtu.dk/en/publications/6368e5c3-04de-46e9-b93c-38c71b9f0688

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The Coordination Modes of (Thio)Semicarbazone Copper(Ii) Complexes Strongly Modulate the Solution Chemical Properties and Mechanism of Anticancer Activity

Autor: Vivien Pósa, Bálint Hajdu, Gábor Tóth, Orsolya Dömötör, Christian R. Kowol, Bernhard K. Keppler, Gabriella Spengler, Béla Gyurcsik, Éva A. Enyedy

Publikováno v: SSRN Electronic Journal.

Thiosemicarbazones are promising candidates for anticancer therapy and their mechanism of action is often linked to their metal chelating ability. In this study, five (thio)semicarbazones with different donor sets (NNS, NNO, ONS, ONO) were selected a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c7f71ee078949b72bdc7c6907f85c0
https://doi.org/10.2139/ssrn.4007992

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A study on the secondary structure of the metalloregulatory protein CueR:effect of pH, metal ions and DNA

Autor: Søren Vrønning Hoffmann, Ria K. Balogh, Eszter Németh, Attila Jancsó, Béla Gyurcsik, Nykola C. Jones

Publikováno v: Balogh, R K, Németh, E, Jones, N C, Hoffmann, S V, Jansco, A & Gyurcsik, B 2021, ' A study on the secondary structure of the metalloregulatory protein CueR : effect of pH, metal ions and DNA ', European Biophysics Journal, vol. 50, pp. 491-500 . https://doi.org/10.1007/s00249-021-01539-z

The response of CueR towards environmental changes in solution was investigated. CueR is a bacterial metal ion selective transcriptional metalloregulator protein, which controls the concentration of copper ions in the cell. Although several articles

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d74f3a9d6aae79664aedfc6bb8ae8c4
https://pure.au.dk/ws/files/305738714/A_study_on_the_secondary_structure_of_the_metalloregulatory_protein_CueR_effect_of_pH_metal_ions_and_DNA.pdf

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Flexibility of the CueR Metal Site Probed by Instantaneous Change of Element and Oxidation State from AgI to CdII

Autor: Peter W. Thulstrup, Mikael Jensen, Ria K. Balogh, Frederik J. Mørch, Marianne L. Jensen, Niels Johan Christensen, Lars Hemmingsen, Attila Jancsó, Béla Gyurcsik, Ulli Köster

Publikováno v: Balogh, R K, Gyurcsik, B, Jensen, M, Thulstrup, P W, Köster, U, Christensen, N J, Mørch, F J, Jensen, M L, Jancsó, A & Hemmingsen, L 2020, ' Flexibility of the CueR Metal Site Probed by Instantaneous Change of Element and Oxidation State from Ag I to Cd II ', Chemistry: A European Journal, vol. 26, no. 33, pp. 7451-7457 . https://doi.org/10.1002/chem.202000132
Balogh, R K, Gyurcsik, B, Jensen, M, Thulstrup, P W, Köster, U, Christensen, N J, Mørch, F J, Jensen, M L, Jancso, A & Hemmingsen, L 2020, ' Flexibility of the CueR Metal Site Probed by Instantaneous Change of Element and Oxidation State from Ag I to Cd II ', Chemistry-A European Journal, vol. 26, no. 33, pp. 7451-7457 . https://doi.org/10.1002/chem.202000132
Chemistry (Weinheim an Der Bergstrasse, Germany)
'Chemistry-A European Journal ', vol: 26, pages: 7451-7457 (2020)

Selectivity for monovalent metal ions is an important facet of the function of the metalloregulatory protein CueR. 111Ag perturbed angular correlation of γ‐rays (PAC) spectroscopy probes the metal site structure and the relaxation accompanying the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2e8885dded3f35982e72607b8ebba6
https://curis.ku.dk/ws/files/242842319/chem.202000132.pdf

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Nickel(ii)-promoted specific hydrolysis of zinc finger proteins

Autor: Bálint Hajdu, Kyosuke Nagata, Wojciech Bal, Agnieszka Belczyk-Ciesielska, Béla Gyurcsik, Aleksandra Sparavier, Masamitsu N. Asaka, Brigitta Csipak

Publikováno v: Metallomics. 10:1089-1098

In this work we demonstrate that the previously described reaction of sequence specific Ni(ii)-dependent hydrolytic peptide bond cleavage can be performed in complex metalloprotein molecules, such as the Cys2His2 zinc finger proteins. The cleavage wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5824bfa83885fae688e6bb638d3bc28
https://doi.org/10.1039/c8mt00098k

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