Stapling of two PEGylated side chains increases the conformational stability of the WW domain via an entropic effect.

Autor: Xiao Q; Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602, USA. jlprice@chem.byu.edu., Bécar NA, Brown NP, Smith MS, Stern KL, Draper SRE, Thompson KP, Price JL

Publikováno v: Organic & biomolecular chemistry [Org Biomol Chem] 2018 Nov 28; Vol. 16 (46), pp. 8933-8939.

Polyethylene Glycol Based Changes to β-Sheet Protein Conformational and Proteolytic Stability Depend on Conjugation Strategy and Location.

Autor: Draper SRE; Department of Chemistry and Biochemistry, Brigham Young University , Provo, Utah 84602, United States., Lawrence PB; Department of Chemistry and Biochemistry, Brigham Young University , Provo, Utah 84602, United States., Billings WM; Department of Chemistry and Biochemistry, Brigham Young University , Provo, Utah 84602, United States., Xiao Q; Department of Chemistry and Biochemistry, Brigham Young University , Provo, Utah 84602, United States., Brown NP; Department of Chemistry and Biochemistry, Brigham Young University , Provo, Utah 84602, United States., Bécar NA; Department of Chemistry and Biochemistry, Brigham Young University , Provo, Utah 84602, United States., Matheson DJ; Department of Chemistry and Biochemistry, Brigham Young University , Provo, Utah 84602, United States., Stephens AR; Department of Chemistry and Biochemistry, Brigham Young University , Provo, Utah 84602, United States., Price JL; Department of Chemistry and Biochemistry, Brigham Young University , Provo, Utah 84602, United States.

Publikováno v: Bioconjugate chemistry [Bioconjug Chem] 2017 Oct 18; Vol. 28 (10), pp. 2507-2513. Date of Electronic Publication: 2017 Oct 09.