Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Béatrix, Bugler"'
Autor:
Pierre Caron, Jonathan Choudjaye, Thomas Clouaire, Béatrix Bugler, Virginie Daburon, Marion Aguirrebengoa, Thomas Mangeat, Jason S. Iacovoni, Alejandro Álvarez-Quilón, Felipe Cortés-Ledesma, Gaëlle Legube
Publikováno v:
Cell Reports, Vol 13, Iss 8, Pp 1598-1609 (2015)
DNA double-strand breaks (DSBs) elicit the so-called DNA damage response (DDR), largely relying on ataxia telangiectasia mutated (ATM) and DNA-dependent protein kinase (DNA-PKcs), two members of the PI3K-like kinase family, whose respective functions
Externí odkaz:
https://doaj.org/article/ade3514d2cc9404f8b5668e7ba76674c
Autor:
Krzysztof Ginalski, François Aymard, Marion Aguirrebengoa, Peter Fraser, Magdalena Skrzypczak, Emmanuelle Guillou, Jason S. Iacovoni, Anna Biernacka, Coline Arnould, Béatrix Bugler, Vincent Rocher, Biola M. Javierre, Gaëlle Legube, Maga Rowicka
Publikováno v:
Nature Structural & Molecular Biology
Nature structural & molecular biology
Nature structural & molecular biology
The ability of DNA double-strand breaks (DSBs) to cluster in mammalian cells has been a subject of intense debate in recent years. Here we used a high-throughput chromosome conformation capture assay (capture Hi-C) to investigate clustering of DSBs i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5af2260651d0d0abda04cae8f41c924c
https://doi.org/10.1038/nsmb.3387
https://doi.org/10.1038/nsmb.3387
Autor:
Odile Mondesert, Bernard Ducommun, Christine Dozier, Stéphane Manenti, Béatrix Bugler, Mathieu Dalvai
Publikováno v:
Oncogene. 32:5123-5128
Cdc25B phosphatases have a key role in G2/M cell-cycle progression by activating the CDK1-cyclinB1 complexes and functioning as important targets of checkpoints. Overexpression of Cdc25B results in a bypass of the G2/M checkpoint and illegitimate ent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b44055b099dec54a7afeb2150f581ba
https://doi.org/10.1038/onc.2012.524
https://doi.org/10.1038/onc.2012.524
Publikováno v:
Cancer Research. 71:1968-1977
CDC25B phosphatases must activate cyclin B-CDK1 complexes to restart the cell cycle after an arrest in G2 phase caused by DNA damage. However, little is known about the precise mechanisms involved in this process, which may exert considerable impact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dabfc94213d6ce3e1c6190ee616fd73d
https://doi.org/10.1158/0008-5472.can-10-2453
https://doi.org/10.1158/0008-5472.can-10-2453
Autor:
Marlène Marcellin, Martine Cazales, Bernadette Aressy, Bernard Ducommun, Odile Burlet-Schiltz, Béatrix Bugler, Denis Jullien
Publikováno v:
Cell Cycle. 9:3839-3846
Tight regulation of cell cycle progression is essential for the maintenance of genomic integrity in response to DNA injury. The aim of this study was to identify new deubiquitinating enzymes (DUBs) involved in the regulation of the G2/M checkpoint. B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::139c788074c44660d9b8ceab26e6712b
https://doi.org/10.4161/cc.9.18.13133
https://doi.org/10.4161/cc.9.18.13133
Autor:
Libor Juha, Kateřina Pachnerová Brabcová, Vaclav Zach, Jean Philippe Champeaux, Martin Vlk, L. Vysin, Pierre Cafarelli, Béatrix Bugler, Václav Štěpán, Jan Stursa, P Moretto-Capelle, Richard Wagner, Gaëlle Legube, Sebastien Incerti, Marie Davídková, Romain Casta, Martine Sence
Publikováno v:
Radiation and Environmental Biophysics
Radiation and Environmental Biophysics, Springer Verlag, 2015, 54 (3), pp.343-352. ⟨10.1007/s00411-015-0605-6⟩
Radiation and Environmental Biophysics, Springer Verlag, 2015, 54 (3), pp.343-352. ⟨10.1007/s00411-015-0605-6⟩
Clustered DNA damage induced by 10, 20 and 30 MeV protons in pBR322 plasmid DNA was investigated. Besides determination of strand breaks, additional lesions were detected using base excision repair enzymes. The plasmid was irradiated in dry form, whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f83f408521231453c3196e45f58866
https://hal.archives-ouvertes.fr/hal-01191763
https://hal.archives-ouvertes.fr/hal-01191763
Autor:
Marie-Christine Brezak, Gregoire Prevost, Béatrix Bugler, Bernard Ducommun, Bernadette Aressy, Muriel Quaranta
Publikováno v:
Molecular Cancer Therapeutics
Molecular Cancer Therapeutics, American Association for Cancer Research, 2006, 5 (6), pp.1446-51. ⟨10.1158/1535-7163.MCT-06-0099⟩
Molecular Cancer Therapeutics, American Association for Cancer Research, 2006, 5 (6), pp.1446-51. ⟨10.1158/1535-7163.MCT-06-0099⟩
Cell cycle arrest at the G2-M checkpoint is an essential feature of the mechanisms that preserve genomic integrity. CDC25 phosphatases control cell cycle progression by dephosphorylating and activating cyclin-dependent kinase/cyclin complexes. Their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cffe840285622d22875138ab55d19cf7
https://doi.org/10.1158/1535-7163.mct-06-0099
https://doi.org/10.1158/1535-7163.mct-06-0099
Publikováno v:
European Journal of Biochemistry. 128:475-480
A high-molecular-mass nucleolar protein (100-kDa protein) is associated with nascent pre-rRNA and pre-ribosomes in Chinese hamster ovary cells. We have prepared antiserum against the 100-kDa protein and we have used it to study the intracellular loca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::330b529d17265fa7f8dc0c9baa0a4a2a
https://doi.org/10.1111/j.1432-1033.1982.tb06989.x
https://doi.org/10.1111/j.1432-1033.1982.tb06989.x
Publikováno v:
ResearcherID
Dimerization is a prerequisite for many growth factors in their receptor activation leading to cellular response. FGF-1 and FGF-2, members of the Fibroblast Growth Factor (FGF) family, were shown to form non-covalent dimers and oligomers in vitro. Us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94e5b62645b055a06224aaca91bbdfb1
https://doi.org/10.1006/bbrc.1998.9668
https://doi.org/10.1006/bbrc.1998.9668
Autor:
Sébastien Briois, François Aymard, Emmanuelle Guillou, Stephen P. Jackson, Gaëlle Legube, Christine K. Schmidt, Jason S. Iacovoni, Béatrix Bugler, Virginie Daburon, Pierre Caron, Kyle M. Miller
Publikováno v:
Nature Structural and Molecular Biology
Nature Structural and Molecular Biology, 2014, 21 (4), pp.366-374. ⟨10.1038/nsmb.2796⟩
Aymard, F, Bugler, B, Schmidt, C, Guillou, E, Caron, P, Briois, S, Iacovoni, J S, Daburon, V, Miller, K M, Jackson, S P & Legube, G 2014, ' Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks. ', Nature Structural and Molecular Biology, vol. 21, pp. 366–374 . https://doi.org/10.1038/nsmb.2796
Nature Structural and Molecular Biology, Nature Publishing Group, 2014, 21 (4), pp.366-374. ⟨10.1038/nsmb.2796⟩
Nature Structural and Molecular Biology, 2014, 21 (4), pp.366-374. ⟨10.1038/nsmb.2796⟩
Aymard, F, Bugler, B, Schmidt, C, Guillou, E, Caron, P, Briois, S, Iacovoni, J S, Daburon, V, Miller, K M, Jackson, S P & Legube, G 2014, ' Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks. ', Nature Structural and Molecular Biology, vol. 21, pp. 366–374 . https://doi.org/10.1038/nsmb.2796
Nature Structural and Molecular Biology, Nature Publishing Group, 2014, 21 (4), pp.366-374. ⟨10.1038/nsmb.2796⟩
While both Homologous recombination (HR) and Non Homologous End Joining (NHEJ) can repair DNA double Strand Breaks (DSB), the mechanisms by which one or other of these pathways is chosen remain unclear. Here we show that transcriptionally active chro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab1d94d5908333b08f7d08e4bebad856
https://hal.science/hal-03477002
https://hal.science/hal-03477002