Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Béatrice Séguin"'
Autor:
Béatrice Séguin, Federico Goodsaid, Gerardo Jimenez-Sanchez, Peter Singer, Abdallah S. Daar, Billie-Jo Hardy
Publikováno v:
Nature Reviews Genetics. 9:S23-S27
This is a historical moment on the path to genomic medicine - the point at which theory is about to be translated into practice. We have previously described human genome variation studies taking place in Mexico, India, Thailand, and South Africa. Su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2585fea006d5c4d79b75c95579c0ed6
https://doi.org/10.1038/nrg2444
https://doi.org/10.1038/nrg2444
Publikováno v:
Nature Reviews Genetics. 9:S14-S19
One potential outcome of investing in genomic medicine is the provision of tools for creating a more cost-effective health-care system. Partly with this aim in mind, Thailand has launched two genotyping initiatives: the Thai SNP Discovery Project and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3b07b0990a39194b375811e78215104
https://doi.org/10.1038/nrg2443
https://doi.org/10.1038/nrg2443
Publikováno v:
Nature Reviews Genetics. 9:S19-S23
The South African government is committed to science and technology innovation, to establishing a knowledge-based economy and to harnessing life-sciences research for health and economic development. Given the constraints and the early stage of devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::305be9aed7f97bf912724f2f6fe658d4
https://doi.org/10.1038/nrg2441
https://doi.org/10.1038/nrg2441
Publikováno v:
Nature Reviews Genetics. 9:S5-S9
In 2004, the government of Mexico established the National Institute of Genomic Medicine (INMEGEN), to carry out disease-related genomic studies that will address national health problems and stimulate scientific and technological development by gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f68f1f7f6244e83c62b6f2adc513eafe
https://doi.org/10.1038/nrg2442
https://doi.org/10.1038/nrg2442
Autor:
Béatrice Séguin, Samir K. Brahmachari, Mitali Mukerji, Billie-Jo Hardy, Abdallah S. Daar, Peter Singer
Publikováno v:
Nature Reviews Genetics. 9:S9-S14
India currently has the world's second-largest population along with a fast-growing economy and significant economic disparity. It also continues to experience a high rate of infectious disease and increasingly higher rates of chronic diseases. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7689f9875874bdd305c4648391fc099c
https://doi.org/10.1038/nrg2440
https://doi.org/10.1038/nrg2440
Publikováno v:
Nature Reviews. Genetics
The authors explore large-scale population genotyping projects in Mexico, India and Thailand to demonstrate that developing countries can harness human genetic variation to benefit their populations — by adopting these resources to improve public h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5050d5738967250e4e9c5a4d4212e926
https://doi.org/10.1038/nrg2379
https://doi.org/10.1038/nrg2379
Publikováno v:
The Pharmacogenomics Journal. 8:169-173
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed42848d31705b0c6858618a9b3e827a
https://doi.org/10.1038/sj.tpj.6500489
https://doi.org/10.1038/sj.tpj.6500489
Publikováno v:
Chemical Research in Toxicology. 18:1193-1202
Idiosyncratic drug reactions (IDRs) cause significant morbidity and mortality. In an animal model of IDRs, 50-80% of Brown Norway rats exposed to D-penicillamine develop an autoimmune syndrome after several weeks of treatment. The symptoms of the IDR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::829e19fd92e9009a4f3a3170c5c5be53
https://doi.org/10.1021/tx050040m
https://doi.org/10.1021/tx050040m
Publikováno v:
Chemical Research in Toxicology. 17:1299-1302
The D-penicillamine autoimmune syndrome observed in Brown Norway (BN) rats is similar to an idiosyncratic reaction seen in some patients. We have previously shown that 2 weeks of low dose (5 mg/day) D-penicillamine pretreatment completely prevented a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc1a86a7506a07a88675182252bdf25
https://doi.org/10.1021/tx0498399
https://doi.org/10.1021/tx0498399
Publikováno v:
Journal of Virology. 72:9503-9513
In the course of examining the various factors which affect the metabolism of human immunodeficiency virus type 1 (HIV-1) RNA, we examined the role of intron sequences and splice sites in determining the subcellular distribution of the RNA. Using in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b53a07e044f0f102b960e6e6dcc167
https://doi.org/10.1128/jvi.72.12.9503-9513.1998
https://doi.org/10.1128/jvi.72.12.9503-9513.1998