Zobrazeno 1 - 10
of 173
pro vyhledávání: '"Béatrice Desvergne"'
Autor:
Christine Cohidon, Regula Cardinaux, Jacques Cornuz, Robin Chenal, Béatrice Desvergne, Idris Guessous, Daniela Cerqui, Daniel Widmer
Publikováno v:
BMC Family Practice, Vol 22, Iss 1, Pp 1-9 (2021)
Abstract Background Direct-to-consumer genetic testing (DTCGT) offers individuals access to information on their probable risks of suffering from a wide range of chronic diseases. General practitioners (GPs) will probably play a major role in support
Externí odkaz:
https://doaj.org/article/3269762631be4512bd46c1fd6ee3cc49
Autor:
Nasim Bararpour, Federica Gilardi, Cristian Carmeli, Jonathan Sidibe, Julijana Ivanisevic, Tiziana Caputo, Marc Augsburger, Silke Grabherr, Béatrice Desvergne, Nicolas Guex, Murielle Bochud, Aurelien Thomas
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract As a powerful phenotyping technology, metabolomics provides new opportunities in biomarker discovery through metabolome-wide association studies (MWAS) and the identification of metabolites having a regulatory effect in various biological pr
Externí odkaz:
https://doaj.org/article/90d0655bcafa4df9b625fb9bc7e81888
Autor:
Maria-Bernadette Madel, He Fu, Dominique D. Pierroz, Mariano Schiffrin, Carine Winkler, Anne Wilson, Cécile Pochon, Barbara Toffoli, Mahdia Taïeb, Jean-Yves Jouzeau, Federica Gilardi, Serge Ferrari, Nicolas Bonnet, Claudine Blin-Wakkach, Béatrice Desvergne, David Moulin
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Long bones from mammals host blood cell formation and contain multiple cell types, including adipocytes. Physiological functions of bone marrow adipocytes are poorly documented. Herein, we used adipocyte-deficient PPARγ-whole body null mice to inves
Externí odkaz:
https://doaj.org/article/b53b90ec113941678457684bbb7bf3ca
Autor:
Mariano Schiffrin, Carine Winkler, Laure Quignodon, Aurélien Naldi, Martin Trötzmüller, Harald Köfeler, Hugues Henry, Paolo Parini, Béatrice Desvergne, Federica Gilardi
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 9969 (2021)
Men with nonalcoholic fatty liver disease (NAFLD) are more exposed to nonalcoholic steatohepatitis (NASH) and liver fibrosis than women. However, the underlying molecular mechanisms of NALFD sex dimorphism are unclear. We combined gene expression, hi
Externí odkaz:
https://doaj.org/article/fa81b10b1f3e4f689e7cd6b6a437344d
Autor:
Alessandra Ferrari, Raffaella Longo, Erika Fiorino, Rui Silva, Nico Mitro, Gaia Cermenati, Federica Gilardi, Béatrice Desvergne, Annapaola Andolfo, Cinzia Magagnotti, Donatella Caruso, Emma De Fabiani, Scott W. Hiebert, Maurizio Crestani
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Histone deacetylases, such as HDAC3, have been shown to alter cellular metabolism in various tissues. Here the authors show that HDAC3 regulates WAT metabolism by activating a futile cycle of fatty acid synthesis and oxidation, which supports WAT bro
Externí odkaz:
https://doaj.org/article/e79e6f94830242d2a35e5f6ab7dac919
Autor:
Leonore Wigger, Cristina Casals-Casas, Michaël Baruchet, Khanh B Trang, Sylvain Pradervand, Aurélien Naldi, Béatrice Desvergne
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0220894 (2019)
Transcriptional regulations exert a critical control of metabolic homeostasis. In particular, the nuclear receptors (NRs) are involved in regulating numerous pathways of the intermediate metabolism. The purpose of the present study was to explore in
Externí odkaz:
https://doaj.org/article/88054e14e6914df09ffb7668fc97a7ef
Autor:
Anne Wilson, He Fu, Mariano Schiffrin, Carine Winkler, Meriem Koufany, Jean-Yves Jouzeau, Nicolas Bonnet, Federica Gilardi, François Renevey, Sanjiv A. Luther, David Moulin, Béatrice Desvergne
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Adult hematopoiesis takes place in the perivascular zone of the bone cavity, where endothelial cells, mesenchymal stromal/stem cells and their derivatives such as osteoblasts are key components of bone marrow (BM) niches. Defining the contribution of
Externí odkaz:
https://doaj.org/article/830f18bf1dc14880a4039984b850a53a
Autor:
Barbara Toffoli, Federica Gilardi, Carine Winkler, Magnus Soderberg, Laura Kowalczuk, Yvan Arsenijevic, Krister Bamberg, Olivier Bonny, Béatrice Desvergne
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171474 (2017)
Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-dependent transcription factor involved in many aspects of metabolism, immune response, and development. Total-body deletion of the two Pparg alleles provoked generalized lipoatrophy
Externí odkaz:
https://doaj.org/article/4ff6c1385d6148348a565d93def9243d
Autor:
Gabriele Dammone, Sonia Karaz, Laura Lukjanenko, Carine Winkler, Federico Sizzano, Guillaume Jacot, Eugenia Migliavacca, Alessio Palini, Béatrice Desvergne, Federica Gilardi, Jerome N. Feige
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 7, p 2044 (2018)
Skeletal muscle is a regenerative tissue which can repair damaged myofibers through the activation of tissue-resident muscle stem cells (MuSCs). Many muscle diseases with impaired regeneration cause excessive adipose tissue accumulation in muscle, al
Externí odkaz:
https://doaj.org/article/f0dad2e6b3ed4c36828ba16715e6c873
Autor:
Federica Gilardi, Eugenia Migliavacca, Aurélien Naldi, Michaël Baruchet, Donatella Canella, Gwendal Le Martelot, Nicolas Guex, Béatrice Desvergne, CycliX Consortium
Publikováno v:
PLoS Genetics, Vol 10, Iss 3, p e1004155 (2014)
In mammals, the circadian clock allows them to anticipate and adapt physiology around the 24 hours. Conversely, metabolism and food consumption regulate the internal clock, pointing the existence of an intricate relationship between nutrient state an
Externí odkaz:
https://doaj.org/article/ecfe00500c864507b9d84869cc8d8fea