Region and dynamic specificities of adult neural stem cells and oligodendrocyte precursors in myelin regeneration in the mouse brain

Autor: Béatrice Brousse, Karine Magalon, Pascale Durbec, Myriam Cayre

Publikováno v: Biology Open, Vol 4, Iss 8, Pp 980-992 (2015)

Myelin regeneration can occur in the brain following demyelination. Parenchymal oligodendrocyte progenitors (pOPC) are known to play a crucial role in this process. Neural stem cells (NSC) residing in the ventricular-subventricular zone (V-SVZ) also

Externí odkaz: https://doaj.org/article/6c0e5057641a4f63b1ec260407d28620

Endogenous neural stem cells modulate microglia and protect against demyelination

Autor: Karine Magalon, Océane Mercier, Béatrice Brousse, Fabrice Daian, Pascale Durbec, Myriam Cayre

Publikováno v: Stem Cell Reports
Stem Cell Reports, 2021, ⟨10.1016/j.stemcr.2021.05.002⟩
Stem Cell Reports, Elsevier, 2021, ⟨10.1016/j.stemcr.2021.05.002⟩

Summary In response to corpus callosum (CC) demyelination, subventricular zone-derived neural progenitors (SVZdNPs) are mobilized and generate new myelinating oligodendrocytes (OLG). Here, we examine the putative immunomodulatory properties of endoge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a276936de6001b71f3762268c9c3ade6
https://hal.science/hal-03268625

Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production

Autor: Céline Zimmer, Magali Macchi, Kay Grobe, Anna Williams, Elitsa Peeva, Pascale Durbec, Bilal El Waly, Friedemann Kiefer, Myriam Cayre, Béatrice Brousse, Sarah Jaekel, Karine Magalon

Publikováno v: eLife
eLife, 2020, 9, ⟨10.7554/eLife.51735⟩
eLife, Vol 9 (2020)
eLife, eLife Sciences Publication, 2020, 9, ⟨10.7554/eLife.51735⟩
Macchi, M, Magalon, K, Zimmer, C, Peeva, E, El Waly, B, Brousse, B, Jaekel, S, Grobe, K, Kiefer, F, Williams, A C, Cayre, M & Durbec, P 2020, ' Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulphate production ', eLIFE . https://doi.org/10.7554/eLife.51735
Macchi, M, Magalon, K, Zimmer, C, Peeva, E, El Waly, B, Brousse, B, Jaekel, S, Grobe, K, Kiefer, F, Williams, A, Cayre, M & Durbec, P 2020, ' Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production ', eLIFE, vol. 9, e51735 . https://doi.org/10.7554/eLife.51735

International audience; Myelin destruction is followed by resident glia activation and mobilization of endogenous progenitors (OPC) which participate in myelin repair. Here we show that in response to demyelination, mature oligodendrocytes (OLG) bord

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b7333643a51e881446ae813238339f9
https://hal.science/hal-02993047/document