Single-Cell RNA Sequencing Reveals Stromal Evolution into LRRC15+ Myofibroblasts as a Determinant of Patient Response to Cancer Immunotherapy

Autor: Melissa R. Junttila, Oded Foreman, Sören Müller, Béatrice Breart, Yuxin Liang, Yasin Senbabaoglu, Christiaan Klijn, Richard Bourgon, Claudia X. Dominguez, Jeffrey Hung, Shilpa Keerthivasan, Travis W. Bainbridge, Zora Modrusan, Hartmut Koeppen, Shannon J. Turley, Alessandra Castiglioni, Sarah Gierke

Publikováno v: Cancer Discovery. 10:232-253

With only a fraction of patients responding to cancer immunotherapy, a better understanding of the entire tumor microenvironment is needed. Using single-cell transcriptomics, we chart the fibroblastic landscape during pancreatic ductal adenocarcinoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b94efb3b9e35dd3ff7f5536128f7e39f
https://doi.org/10.1158/2159-8290.cd-19-0644

Bystander IFN-γ activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment

Autor: Benno Schwikowski, Marine Cazaux, Zacarias Garcia, Philippe Bousso, Ronan Thibaut, Pierre Bost, Béatrice Breart, Ido Amit, Clémence Cornuot, Fabrice Lemaître, Idan Milo

Publikováno v: Nature Cancer
Nature Cancer, 2020, 1 (3), pp.302-314. ⟨10.1038/s43018-020-0038-2⟩
Nature Cancer, Nature Research 2020, 1 (3), pp.302-314. ⟨10.1038/s43018-020-0038-2⟩

The cytokine interferon (IFN)-γ produced by tumor-reactive T cells is a key effector molecule with pleiotropic effects during anti-tumor immune responses. Although IFN-γ production is targeted at the immunologic synapse, its spatiotemporal activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d78d909bf922192f484c0466ee48448d
https://hal.science/hal-02930398

S1P 1 downregulation tailors CD8 + T-cell residence time in lymph nodes to the strength of the antigenic stimulation

Autor: Philippe Bousso, Béatrice Breart

Publikováno v: European Journal of Immunology
European Journal of Immunology, 2016, 46 (12), pp.2730-2736. ⟨10.1002/eji.201646550⟩
European Journal of Immunology, Wiley-VCH Verlag, 2016, 46 (12), pp.2730-2736. ⟨10.1002/eji.201646550⟩

International audience; T cells are sequestered for several days in lymph nodes following antigen recognition but the precise mechanism regulating their timing of egress is not fully understood. In particular, whether interactions with antigen-presen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::939aead6b9da7f9b41f85b143b7a7e9f
https://hal-pasteur.archives-ouvertes.fr/pasteur-01403268

Intravital imaging reveals improved Kupffer cell-mediated phagocytosis as a mode of action of glycoengineered anti-CD20 antibodies

Autor: David Michonneau, Béatrice Breart, Christian Gerdes, Fabricio Montalvao, Capucine L. Grandjean, Philippe Bousso, Zacarias Garcia, Susanna Celli, Olivier Freytag, Mario Perro

Publikováno v: Scientific Reports
Scientific Reports, 2016, 6, pp.361-7. ⟨10.1038/srep34382⟩
Scientific Reports, Nature Publishing Group, 2016, 6, pp.361-7. ⟨10.1038/srep34382⟩

Anti-CD20 monoclonal antibodies (mAbs) represent an effective treatment for a number of B cell malignancies and autoimmune disorders. Glycoengineering of anti-CD20mAb may contribute to increased anti-tumor efficacy through enhanced antibody-dependent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe3dff4c65203d1362f1db3cd84fe904
https://hal-pasteur.archives-ouvertes.fr/pasteur-01403272

The PD-1 Axis Enforces an Anatomical Segregation of CTL Activity that Creates Tumor Niches after Allogeneic Hematopoietic Stem Cell Transplantation

Autor: Béatrice Breart, Susanna Celli, David Michonneau, Pervinder Sagoo, Zacarias Garcia, Philippe Bousso

Publikováno v: Immunity
Immunity, 2016, CellPress, 44 (1), p143-154. ⟨10.1016/j.immuni.2015.12.008⟩
Immunity, Elsevier, 2016, CellPress, 44 (1), p143-154. ⟨10.1016/j.immuni.2015.12.008⟩

International audience; Allogeneic hematopoietic stem cell transplantation (allo-HSCT), a curative treatment for hematologic malignancies relies on donor cytotoxic T lymphocyte (CTL)-mediated graft-versus-leukemia (GVL) effect. Major complications of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb94e9b006dd5ed6d23bf3f2ddca851e
https://hal-pasteur.archives-ouvertes.fr/pasteur-01296510/document