Zika Virus Inhibits IFN-α Response by Human Plasmacytoid Dendritic Cells and Induces NS1-Dependent Triggering of CD303 (BDCA-2) Signaling

Autor: Sandra Bos, Béatrice Poirier-Beaudouin, Valérie Seffer, Maria Manich, Cartini Mardi, Philippe Desprès, Gilles Gadea, Marie-Lise Gougeon

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Zika virus (ZIKV) dramatically emerged in French Polynesia and subsequently in the Americas where it has been associated with severe neurological complications in adults and newborns, respectively. Although plasmacytoid dendritic cells (pDCs) are a k

Externí odkaz: https://doaj.org/article/02879f123173421ca472cccc94e9d6b6

Human papilloma virus‐16‐specific CD8 + T‐cell expansions characterize different clinical forms of lichen planus and not lichen sclerosus et atrophicus

Autor: Manuelle Viguier, Corine Pérals, Béatrice Poirier, Maxime Battistella, François Aubin, Hervé Bachelez, Jean‐Luc Prétet, Tarik Gheit, Massimo Tommasino, Antoine Touzé, Marie‐Lise Gougeon, Nicolas Fazilleau

Publikováno v: Experimental Dermatology
Experimental Dermatology, 2023, 32 (6), pp.859-868. ⟨10.1111/exd.14788⟩

International audience; Lichen planus (LP) is a cutaneomucosal chronic inflammatory disease characterized by a CD8 + cytotoxic T-lymphocytes (CTL) infiltrate. In erosive oral LP, we found HPV16specific activated CTL in lesions, supporting a pathogeni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::730be591820813546dae3eab776425c3
https://doi.org/10.1111/exd.14788

HMGB1/anti-HMGB1 antibodies define a molecular signature of early stages of HIV-Associated Neurocognitive Disorders (HAND)

Autor: Marie-Lise Gougeon, Béatrice Poirier-Beaudouin, Jacques Durant, Christine Lebrun-Frenay, Héla Saïdi, Valérie Seffer, Michel Ticchioni, Stephane Chanalet, Helene Carsenti, Alexandra Harvey-Langton, Muriel Laffon, Jacqueline Cottalorda, Christian Pradier, Pierre Dellamonica, Matteo Vassallo

Publikováno v: Heliyon, Vol 3, Iss 2, Pp e00245- (2017)

Background: HIV-associated neurocognitive disorders (HAND) persist in the post-HAART era, characterized by asymptomatic neurocognitive impairment (ANI) and mild neurocognitive disorders (MND). High mobility group box 1 (HMGB1) is a non-histone chromo

Externí odkaz: https://doaj.org/article/0589c599a7554d9f8db1a2b947d4be38

Intracerebral Gene Therapy in Four Children with Sanfilippo B Syndrome: 5.5-Year Follow-Up Results

Autor: Jérôme Ausseil, Béatrice Poirier-Beaudouin, Marie-Lise Gougeon, Béatrice Husson, Dimitrios I. Zafeiriou, Marc Tardieu, Giancarlo Parenti, Kumaran Deiva, Michel Zerah, Stéphanie de Bournonville, Jean-Michel Heard

Publikováno v: Human Gene Therapy
Human Gene Therapy, 2021, 32 (19-20), pp.1251-1259. ⟨10.1089/hum.2021.135⟩

International audience; We report the safety (primary endpoint) and efficacy (secondary endpoint) of a novel intracerebral gene therapy at 5.5 years of follow-up in children with Sanfilippo B. An uncontrolled, phase 1/2 clinical trial was performed i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5656e00806ab496dfb15526727215b31
http://hdl.handle.net/11588/870281

HIV-1 Envelope Overcomes NLRP3-Mediated Inhibition of F-Actin Polymerization for Viral Entry

Autor: Haithem Dakhli, David M. Ojcius, Maxime Thoreau, Héla Saïdi, Eric Solary, Awatef Allouch, Jean-Luc Perfettini, Olivier Lambotte, Marina Caillet, Eric Deutsch, Olivier Delelis, Qiuji Wu, Zeinaf Muradova, Mauro Piacentini, Gianfranco Pancino, Roger Le Grand, Syed Qasim Raza, Audrey Paoletti, Asier Sáez-Cirión, Béatrice Poirier-Beaudouin, Nathalie Dereuddre-Bosquet, Frédéric Subra, Laurent Voisin, Guido Kroemer, Marie-Lise Gougeon, Roberta Nardacci, Frédéric Law

Publikováno v: Cell Reports
Cell Reports, 2019, 28 (13), pp.3381-3394.e7. ⟨10.1016/j.celrep.2019.02.095⟩
Cell Reports, Elsevier Inc, 2019, 28 (13), pp.3381-3394.e7. ⟨10.1016/j.celrep.2019.02.095⟩
Cell Reports, Vol 28, Iss 13, Pp 3381-3394.e7 (2019)

Summary: Purinergic receptors and nucleotide-binding domain leucine-rich repeat containing (NLR) proteins have been shown to control viral infection. Here, we show that the NLR family member NLRP3 and the purinergic receptor P2Y2 constitutively inter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ced07d28bc4369962d1800230140545
https://cea.hal.science/cea-02316814/file/1-s2.0-S2211124719302815-main.pdf