Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Bäte C"'
Publikováno v:
Molecular Neurodegeneration, Vol 5, Iss 1, p 55 (2010)
Abstract Background The pathogenesis of Parkinson's disease (PD) and dementia with Lewy bodies (DLB) is associated with the accumulation of aggregated forms of the α-synuclein (αSN) protein. An early event in the neuropathology of PD and DLB is the
Externí odkaz:
https://doaj.org/article/d3b4f5f3c5ab4a3cafa80966ef18a95e
Publikováno v:
Molecular Neurodegeneration, Vol 5, Iss 1, p 13 (2010)
Abstract Background An early event in the neuropathology of prion and Alzheimer's diseases is the loss of synapses and a corresponding reduction in the level of synaptophysin, a pre-synaptic membrane protein essential for neurotransmission. The molec
Externí odkaz:
https://doaj.org/article/f2f066842f554be382940c543cb918da
Publikováno v:
BMC Biology, Vol 6, Iss 1, p 39 (2008)
Abstract Background The transmissible spongiform encephalopathies, otherwise known as prion diseases, occur following the conversion of the cellular prion protein (PrPC) to an alternatively folded, disease-associated isoform (PrPSc). Recent studies s
Externí odkaz:
https://doaj.org/article/89126ade0a8149888277e39de3ce9e3b
Publikováno v:
BMC Biology, Vol 6, Iss 1, p 8 (2008)
Abstract Background The transmissible spongiform encephalopathies (TSEs), otherwise known as the prion diseases, occur following the conversion of the normal cellular prion protein (PrPC) to an alternatively folded isoform (PrPSc). The accumulation o
Externí odkaz:
https://doaj.org/article/73cc37b33e6c4a3ca6967b76c3005e08
Publikováno v:
Molecular Neurodegeneration, Vol 3, Iss 1, p 1 (2008)
Abstract Background The early stages of Alzheimer's disease (AD) are closely associated with the production of the Aβ1–42 peptide, loss of synapses and gradual cognitive decline. Since some epidemiological studies showed that EGb 761, an extract f
Externí odkaz:
https://doaj.org/article/98502e3c4e5b43c09e404fb6ae3f831a
Publikováno v:
BMC Neuroscience, Vol 8, Iss 1, p 99 (2007)
Abstract Background Neurotoxic peptides derived from the protease-resistant core of the prion protein are used to model the pathogenesis of prion diseases. The current study characterised the ingestion, internalization and intracellular trafficking o
Externí odkaz:
https://doaj.org/article/97e0da679984403a8de0707a65129fc8
Publikováno v:
Journal of Neuroinflammation, Vol 4, Iss 1, p 5 (2007)
Abstract Background Platelet-activating factor (PAF) is implicated in the neuronal damage that accompanies ischemia, prion disease and Alzheimer's disease (AD). Since some epidemiological studies demonstrate that statins, drugs that reduce cholestero
Externí odkaz:
https://doaj.org/article/6a3273d45f524128a7eb8c7d0b91b8c7
Publikováno v:
Journal of Neuroinflammation, Vol 3, Iss 1, p 7 (2006)
Abstract Background Alzheimer's disease is a neurodegenerative disorder characterized by a progressive cognitive impairment, the consequence of neuronal dysfunction and ultimately the death of neurons. The amyloid hypothesis proposes that neuronal da
Externí odkaz:
https://doaj.org/article/0480898528f34a24a6635da5499061c4
Publikováno v:
Journal of Neuroinflammation, Vol 1, Iss 1, p 4 (2004)
Abstract Background Neuronal loss in Alzheimer's or prion diseases is preceded by the accumulation of fibrillar aggregates of toxic proteins (amyloid-β1-42 or the prion protein). Since some epidemiological studies have demonstrated that the EGb 761
Externí odkaz:
https://doaj.org/article/452048c948534f01913db3c9e65d480b
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