Determination of DTaP vaccine potency by multiplex immunogenicity testing using electrochemiluminescence

Autor: Bärbel Friedrichs, Simone Rehg, Kay-Martin Hanschmann, Volker Öppling, Isabelle Bekeredjian-Ding

Publikováno v: npj Vaccines, Vol 9, Iss 1, Pp 1-12 (2024)

Abstract Lot release testing of diphtheria, tetanus and acellular pertussis vaccines traditionally relied on in vivo protection models involving challenge of laboratory animals with toxins. Meanwhile, many labs have switched to serological testing of

Externí odkaz: https://doaj.org/article/3801193e6be9480c87adcbc8df0299fe

Fostering Responsible Research with Genome Editing Technologies: a European Perspective

Autor: Mylene Botbol-Baum, Marion Abecassis, Johannes Rath, Ewa Bartnik, François Hirsch, Agnes Saint-Raymond, Albrecht M. Müller, Jennifer Merchant, Hervé Chneiweiss, Mihalis Kritikos, Bernard Baertschi, Ana Sofia Carvalho, Christiane Druml, James A. Houghton, Solveig Fenet, Lluis Montoliu, Bärbel Friedrich, Dirk Lanzerath, Janet Mifsud

Publikováno v: Transgenic Research
Transgenic Research, Springer Verlag, 2017, Epub ahead of print. ⟨10.1007/s11248-017-0028-z⟩
Transgenic Research, Vol. 26, no.5, p. 709-713 (2017)
Transgenic Research, 2017, Epub ahead of print. ⟨10.1007/s11248-017-0028-z⟩

In this consensus paper resulting from a meeting that involved representatives from more than 20 European partners, we recommend the foundation of an expert group (European Steering Committee) to assess the potential benefits and draw-backs of genome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71677253c7a66ef29ed3d6c38b54bdef
https://www.hal.inserm.fr/inserm-01586239

CO synthesized from the central one-carbon pool as source for the iron carbonyl in O2-tolerant [NiFe]-hydrogenase

Autor: Ingo Zebger, Ingmar Bürstel, Oliver Lenz, Bärbel Friedrich, Elisabeth Siebert, Stefan Frielingsdorf

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 113(51)

Hydrogenases are nature's key catalysts involved in both microbial consumption and production of molecular hydrogen. H2 exhibits a strongly bonded, almost inert electron pair and requires transition metals for activation. Consequently, all hydrogenas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83723056afd33850ea1a2d333a31d909
https://pubmed.ncbi.nlm.nih.gov/27930319

Electrocatalytic hydrogen oxidation by an enzyme at high carbon monoxide or oxygen levels

Autor: Oliver Lenz, Fraser A. Armstrong, Ingo Zebger, James A. Cracknell, Kylie A. Vincent, Bärbel Friedrich

Use of hydrogen in fuel cells requires catalysts that are tolerant to oxygen and are able to function in the presence of poisons such as carbon monoxide. Hydrogen-cycling catalysts are widespread in the bacterial world in the form of hydrogenases, en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b566fadc3779eff739de00ae6c6c40d
https://doi.org/10.1073/pnas.0504499102

Probing the Origin of the Metabolic Precursor of the CO Ligand in the Catalytic Center of [NiFe] Hydrogenase

Autor: Ingmar Bürstel, Oliver Lenz, Ingo Zebger, Bärbel Friedrich, Nattawadee Wisitruangsakul, Elisabeth Siebert, Philipp Hummel

Publikováno v: Journal of Biological Chemistry. 286:44937-44944

The O(2)-tolerant [NiFe] hydrogenases of Ralstonia eutropha are capable of H(2) conversion in the presence of ambient O(2). Oxygen represents not only a challenge for catalysis but also for the complex assembling process of the [NiFe] active site. Ap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::018e3fa3b015df4071ee9e9619863231
https://doi.org/10.1074/jbc.m111.309351