Integrative analysis of single-cell expression data reveals distinct regulatory states in bidirectional promoters

Autor: Fatemeh Behjati Ardakani, Kathrin Kattler, Karl Nordström, Nina Gasparoni, Gilles Gasparoni, Sarah Fuchs, Anupam Sinha, Matthias Barann, Peter Ebert, Jonas Fischer, Barbara Hutter, Gideon Zipprich, Charles D. Imbusch, Bärbel Felder, Jürgen Eils, Benedikt Brors, Thomas Lengauer, Thomas Manke, Philip Rosenstiel, Jörn Walter, Marcel H. Schulz

Publikováno v: Epigenetics & Chromatin, Vol 11, Iss 1, Pp 1-14 (2018)

Abstract Background Bidirectional promoters (BPs) are prevalent in eukaryotic genomes. However, it is poorly understood how the cell integrates different epigenomic information, such as transcription factor (TF) binding and chromatin marks, to drive

Externí odkaz: https://doaj.org/article/aeda19e919924fcba37b9cf5784814fb

Abstract PD2-04: Molecular plasticity of luminal breast cancer and response to CDK 4/6 inhibition - The biomarker program of the PENELOPE-B trial investigating post-neoadjuvant palbociclib

Autor: Carsten Denkert, Frederik Marmé, Miguel Martin, Michael Untch, Hervé Bonnefoi, Sung-Bae Kim, Harry Bear, Agnieszka Witkiewicz, Seock-Ah Im, Angela DeMichele, Laura Van’t Veer, Nicole McCarthy, Thorsten Stiewe, Karen A. Gelmon, José A. García-Sáenz, Catherine M. Kelly, Toralf Reimer, Erik Knudsen, Nicholas Turner, Federico Rojo, Peter A. Fasching, Julia Teply-Szymanski, Yuan Liu, Masakazu Toi, Hope S. Rugo, Michael Gnant, Andreas Makris, Bärbel Felder, Karsten Weber, Sibylle Loibl

Publikováno v: Cancer Research. 82:PD2-04

Background: Molecular plasticity of breast cancer is crucial for the development of therapy-resistant disease. In this investigation, we studied changes in molecular signatures between pretherapeutic (pre-Tx) and post-therapeutic (post-NACT) tumor sa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8be49c38a5f2f4a63b91fbc6a049cc49
https://doi.org/10.1158/1538-7445.sabcs21-pd2-04

Epigenetic Dynamics of Monocyte-to-Macrophage Differentiation

Autor: Karl Nordström, Gilles Gasparoni, Sebastian Fröhler, Gideon Zipprich, Elsa Leitão, Thomas Manke, Ludger Klein-Hitpass, Wei Chen, Daniela Beißer, Christopher Schröder, Gerd Schmitz, Bernhard Horsthemke, Tea Berulava, Jörn Walter, Matthias Barann, Thomas Lengauer, Philip Rosenstiel, Ulrike Bönisch, Stefan Wallner, Claudia Haak, Corinna Attenberger, Filippos Klironomos, Bärbel Felder, Sven Rahmann, Peter Ebert, Laura Arrigoni, Andreas S. Richter, Fabian Müller, Benedikt Brors, Nikolaus Rajewsky

Publikováno v: Epigenetics & Chromatin

Background Monocyte-to-macrophage differentiation involves major biochemical and structural changes. In order to elucidate the role of gene regulatory changes during this process, we used high-throughput sequencing to analyze the complete transcripto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90b0d643fe419e417dd56d39097064a7
https://hdl.handle.net/11858/00-001M-0000-002B-1693-211858/00-001M-0000-002B-1691-6

Evaluation of BMP4 and its specific inhibitor NOG as candidates in human neural tube defects (NTDs)

Autor: Almut Schultealbert, Manuela C. Koch, Frank Geller, Bärbel Felder, Elisabeth Strehl, August Ermert, Karolin Stegmann

Publikováno v: European Journal of Human Genetics. 10:753-756

Neural tube defects (NTD) are among the most common congenital malformations in humans. The current view is that there are no major genes causing NTDs, but combinations of sequence variants in different genes have additive effects on determining the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83fa1d97394253b2bcd3d0b67366d8a8
https://doi.org/10.1038/sj.ejhg.5200875

Mapping autism risk loci using genetic linkage and chromosomal rearrangements

Autor: Peter, Szatmari, Andrew D, Paterson, Lonnie, Zwaigenbaum, Wendy, Roberts, Jessica, Brian, Xiao-Qing, Liu, John B, Vincent, Jennifer L, Skaug, Ann P, Thompson, Lili, Senman, Lars, Feuk, Cheng, Qian, Susan E, Bryson, Marshall B, Jones, Christian R, Marshall, Stephen W, Scherer, Veronica J, Vieland, Christopher, Bartlett, La Vonne, Mangin, Rhinda, Goedken, Alberto, Segre, Margaret A, Pericak-Vance, Michael L, Cuccaro, John R, Gilbert, Harry H, Wright, Ruth K, Abramson, Catalina, Betancur, Thomas, Bourgeron, Christopher, Gillberg, Marion, Leboyer, Joseph D, Buxbaum, Kenneth L, Davis, Eric, Hollander, Jeremy M, Silverman, Joachim, Hallmayer, Linda, Lotspeich, James S, Sutcliffe, Jonathan L, Haines, Susan E, Folstein, Joseph, Piven, Thomas H, Wassink, Val, Sheffield, Daniel H, Geschwind, Maja, Bucan, W Ted, Brown, Rita M, Cantor, John N, Constantino, T Conrad, Gilliam, Martha, Herbert, Clara, Lajonchere, David H, Ledbetter, Christa, Lese-Martin, Janet, Miller, Stan, Nelson, Carol A, Samango-Sprouse, Sarah, Spence, Matthew, State, Rudolph E, Tanzi, Hilary, Coon, Geraldine, Dawson, Bernie, Devlin, Annette, Estes, Pamela, Flodman, Lambertus, Klei, William M, McMahon, Nancy, Minshew, Jeff, Munson, Elena, Korvatska, Patricia M, Rodier, Gerard D, Schellenberg, Moyra, Smith, M Anne, Spence, Chris, Stodgell, Ping Guo, Tepper, Ellen M, Wijsman, Chang-En, Yu, Bernadette, Rogé, Carine, Mantoulan, Kerstin, Wittemeyer, Annemarie, Poustka, Bärbel, Felder, Sabine M, Klauck, Claudia, Schuster, Fritz, Poustka, Sven, Bölte, Sabine, Feineis-Matthews, Evelyn, Herbrecht, Gabi, Schmötzer, John, Tsiantis, Katerina, Papanikolaou, Elena, Maestrini, Elena, Bacchelli, Francesca, Blasi, Simona, Carone, Claudio, Toma, Herman, Van Engeland, Maretha, de Jonge, Chantal, Kemner, Frederieke, Koop, Frederike, Koop, Marjolein, Langemeijer, Marjolijn, Langemeijer, Channa, Hijmans, Channa, Hijimans, Wouter G, Staal, Gillian, Baird, Patrick F, Bolton, Michael L, Rutter, Emma, Weisblatt, Jonathan, Green, Catherine, Aldred, Julie-Anne, Wilkinson, Andrew, Pickles, Ann, Le Couteur, Tom, Berney, Helen, McConachie, Anthony J, Bailey, Kostas, Francis, Gemma, Honeyman, Aislinn, Hutchinson, Jeremy R, Parr, Simon, Wallace, Anthony P, Monaco, Gabrielle, Barnby, Kazuhiro, Kobayashi, Janine A, Lamb, Ines, Sousa, Nuala, Sykes, Edwin H, Cook, Stephen J, Guter, Bennett L, Leventhal, Jeff, Salt, Catherine, Lord, Christina, Corsello, Vanessa, Hus, Daniel E, Weeks, Fred, Volkmar, Maïté, Tauber, Eric, Fombonne, Andy, Shih, Kacie J, Meyer

Publikováno v: Nature Genetics
Nature Genetics, Nature Publishing Group, 2007, 39 (3), pp.319-28. ⟨10.1038/ng1985⟩
Nature Genetics, 39(3), 319-28. Nature Publishing Group
Nature Genetics, 2007, 39 (3), pp.319-28. ⟨10.1038/ng1985⟩
Szatmari, P, Paterson, A D, Zwaigenbaum, L, Roberts, W, Brian, J, Liu, X-Q, Vincent, J B, Skaug, J L, Thompson, A P, Senman, L, Feuk, L, Qian, C, Bryson, S E, Jones, M B, Marshall, C R, Scherer, S W, Vieland, V J, Bartlett, C, Mangin, L V, Goedken, R, Segre, A, Pericak-Vance, M A, Cuccaro, M L, Gilbert, J R, Wright, H H, Abramson, R K, Betancur, C, Bourgeron, T, Gillberg, C, Leboyer, M, Buxbaum, J D, Davis, K L, Hollander, E, Silverman, J M, Hallmayer, J, Lotspeich, L, Sutcliffe, J S, Haines, J L, Folstein, S E, Piven, J, Wassink, T H, Sheffield, V, Geschwind, D H, Bucan, M, Brown, W T, Cantor, R M, Constantino, J N, Baird, G, Bolton, P F, Rutter, M L 2007, ' Mapping autism risk loci using genetic linkage and chromosomal rearrangements ', Nature Genetics, vol. 39, no. 3, pp. 319-328 . https://doi.org/10.1038/ng1985

International audience; Autism spectrum disorders (ASDs) are common, heritable neurodevelopmental conditions. The genetic architecture of ASDs is complex, requiring large samples to overcome heterogeneity. Here we broaden coverage and sample size rel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b4ba5a0896229e2dd78390a6ddd5723
https://www.hal.inserm.fr/inserm-00937094/file/AGP_Nat_Genet_2007.pdf