Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Bárbara de la Peña Avalos"'
Autor:
Patrick J. Conway, Bárbara De La Peña Avalos, Jonathan Dao, Sebastian Montagnino, Dmytro Kovalskyy, Eloise Dray, Daruka Mahadevan
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 55, Iss , Pp 101014- (2024)
Chemotherapy induced polyploidy is a mechanism of inherited drug resistance resulting in an aggressive disease course in cancer patients. Alisertib, an Aurora Kinase A (AK-A) ATP site inhibitor, induces cell cycle disruption resulting in polyaneuploi
Externí odkaz:
https://doaj.org/article/fdf3550c509b4ad3a071ef8341bf288c
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-18 (2023)
Abstract The Eyes Absent (EYA) family of proteins is an atypical group of four dual-functioning protein phosphatases (PP), which have been linked to many vital cellular processes and organogenesis pathways. The four family members of this PP family p
Externí odkaz:
https://doaj.org/article/84a501a5d1624c18945c54c7315e35a6
The Eyes Absent (EYA) family of proteins is an atypical group of four dual-functioning protein phosphatases, which have been linked to many vital cellular processes and organogenesis pathways. Like the other isoforms, EYA4 possesses transcriptional a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acb31d56d3a005d053d42a7c2aa05125
https://doi.org/10.21203/rs.3.rs-2917471/v1
https://doi.org/10.21203/rs.3.rs-2917471/v1
Autor:
Anand V.R. Kornepati, Jacob T. Boyd, Clare E. Murray, Julia Saifetiarova, Bárbara de la Peña Avalos, Cody M. Rogers, Haiyan Bai, Alvaro S. Padron, Yiji Liao, Carlos Ontiveros, Robert S. Svatek, Robert Hromas, Rong Li, Yanfen Hu, Jose R. Conejo-Garcia, Ratna K. Vadlamudi, Weixing Zhao, Eloïse Dray, Patrick Sung, Tyler J. Curiel
Publikováno v:
Cancer Res
BRCA1-mediated homologous recombination is an important DNA repair mechanism that is the target of FDA-approved PARP inhibitors, yet details of BRCA1-mediated functions remain to be fully elucidated. Similarly, immune checkpoint molecules are targets
Autor:
Yiji Liao, Chen-Hao Chen, Tengfei Xiao, Bárbara de la Peña Avalos, Eloise V. Dray, Changmeng Cai, Shuai Gao, Neel Shah, Zhao Zhang, Avery Feit, Pengya Xue, Zhijie Liu, Mei Yang, Ji Hoon Lee, Han Xu, Wei Li, Shenglin Mei, Roodolph S. Pierre, Shaokun Shu, Teng Fei, Melissa Duarte, Jin Zhao, James E. Bradner, Kornelia Polyak, Philip W. Kantoff, Henry Long, Steven P. Balk, X. Shirley Liu, Myles Brown, Kexin Xu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance We identified a group of DNA repair genes directly induced by EZH2 and repressed by EZH2 inhibitors. Expression of these genes predicts the response of wild-type EZH2-harboring solid tumors to EZH2 inhibitors. Most importantly, our findi
Autor:
Jason Meyer, Angela Jacques, James Walsham, Peter Kruger, Kerina J. Denny, Jeffery Lipman, Anqi Li, Kirstin Elgass, Bárbara de la Peña Avalos, Yih Rue Ong, Qiang Cheng, Emma Saylor
Background: The lack of rapid and accurate diagnostic tools to distinguish infectious (known as sepsis) and non-infectious causes of inflammation in patients with systemic inflammation remains a significantly unmet clinic need, particularly in the in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::480417a846b3bef216d12c64dc4c6b79
https://doi.org/10.21203/rs.3.rs-1007613/v1
https://doi.org/10.21203/rs.3.rs-1007613/v1
Autor:
Martine Roudier, Siyuan Zheng, Yiji Liao, Zhao Zhang, Douglas Pechacek, Kevin Vu, Teresa L. Johnson-Pais, Eloise Dray, Robin J. Leach, Mei Yang, Agustina Roldán Deamicis, Cecilia J. Proietti, Hung-Ming Lam, Bárbara de la Peña Avalos, Pooja Yadav, Juyeong Hong, Richard De La Rosa, Ji Hoon Lee, G. Pablo Guzmán, Anthony Sisk, Jose M. Garcia, Manjeet K. Rao, Jessica Scheirer, Kexin Xu, Patricia V. Elizalde
Publikováno v:
Science Advances
Down-regulation of HMBOX1 via METTL3-catalyzed m6A causes genomic instability driven by telomere dysfunction in cancer.
The role of RNA methylation on N6-adenosine (m6A) in cancer has been acknowledged, but the underlying mechanisms remain obscu
The role of RNA methylation on N6-adenosine (m6A) in cancer has been acknowledged, but the underlying mechanisms remain obscu
Autor:
Romain Tropée, Madeline Gough, Pascal H.G. Duijf, Cameron Snell, Eloise Dray, Bárbara de la Peña Avalos
Publikováno v:
Breast Cancer Res Treat
Purpose: Chromatin remodeling plays an essential role in regulating transcriptional networks and timing of gene expression. Chromatin remodelers such as SWItch/Sucrose Non-Fermentable (SWI/SNF) harbor many protein components, with the catalytic subun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc6d42b3a0d7d6a4bf1a35958cce76e7
https://hdl.handle.net/11541.2/34231
https://hdl.handle.net/11541.2/34231
Autor:
Eloise Dray, Bárbara de la Peña Avalos
Publikováno v:
Journal of Visualized Experiments.
Mammalian cells are constantly exposed to chemicals, radiations, and naturally occurring metabolic by-products, which create specific types of DNA insults. Genotoxic agents can damage the DNA backbone, break it, or modify the chemical nature of indiv
Autor:
Zexuan Liu, Weixing Zhao, Clare Murray, Bárbara de la Peña Avalos, Yilun Deng, Cody M. Rogers, Alvaro Padron, Eloise Dray, Harshita Gupta, Patrick Sung, Kavya Ramkumar, Ratna K. Vadlamudi, Anand Kornepati, Lauren Averett Byers, Tyler J. Curiel
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundTumor surface-expressed programmed death-ligand 1 (PD-L1) suppresses immunity when it engages programmed death-1 (PD-1) on anti-tumor immune cells in canonical PD-L1/PD-1.1 Non-canonical, tumour-intrinsic PD-L1 signals can mediate treatment