Mosaic deletion of claudin-5 reveals rapid non-cell-autonomous consequences of blood-brain barrier leakage

Autor: Elisa Vázquez-Liébanas, Giuseppe Mocci, Weihan Li, Bàrbara Laviña, Avril Reddy, Claire O’Connor, Natalie Hudson, Zaher Elbeck, Ioannis Nikoloudis, Konstantin Gaengel, Michael Vanlandewijck, Matthew Campbell, Christer Betsholtz, Maarja Andaloussi Mäe

Publikováno v: Cell Reports, Vol 43, Iss 3, Pp 113911- (2024)

Summary: Claudin-5 (CLDN5) is an endothelial tight junction protein essential for blood-brain barrier (BBB) formation. Abnormal CLDN5 expression is common in brain disease, and knockdown of Cldn5 at the BBB has been proposed to facilitate drug delive

Externí odkaz: https://doaj.org/article/d34577273d7342149fefcf704bebdf82

Intravital imaging-based analysis tools for vessel identification and assessment of concurrent dynamic vascular events

Autor: Naoki Honkura, Mark Richards, Bàrbara Laviña, Miguel Sáinz-Jaspeado, Christer Betsholtz, Lena Claesson-Welsh

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)

Different stimuli can induce dynamic changes in blood flow velocity, vessel diameter and permeability. Here the authors develop a multi-photon microscopy-based image analysis tool allowing the identification of vessels and the assessment of rapid cha

Externí odkaz: https://doaj.org/article/5f724ed68afa4984a0c4a2a53150e86d

Gpr116 Receptor Regulates Distinctive Functions in Pneumocytes and Vascular Endothelium.

Autor: Colin Niaudet, Jennifer J Hofmann, Maarja A Mäe, Bongnam Jung, Konstantin Gaengel, Michael Vanlandewijck, Elisabet Ekvärn, M Dolores Salvado, Annika Mehlem, Sahar Al Sayegh, Liqun He, Thibaud Lebouvier, Marco Castro-Freire, Kan Katayama, Kjell Hultenby, Christine Moessinger, Philip Tannenberg, Sara Cunha, Kristian Pietras, Bàrbara Laviña, JongWook Hong, Tove Berg, Christer Betsholtz

Publikováno v: PLoS ONE, Vol 10, Iss 9, p e0137949 (2015)

Despite its known expression in both the vascular endothelium and the lung epithelium, until recently the physiological role of the adhesion receptor Gpr116/ADGRF5 has remained elusive. We generated a new mouse model of constitutive Gpr116 inactivati

Externí odkaz: https://doaj.org/article/6f2f517b62c14130b740db03e8f5de3c

Adgrf5 contributes to patterning of the endothelial deep layer in retina

Autor: S. Lu, Colin Niaudet, Cord Brakebusch, Bàrbara Laviña, Christer Betsholtz, Milena Petkova, Stefan Offermanns, Bongnam Jung

Publikováno v: Angiogenesis
Niaudet, C, Petkova, M, Jung, B, Lu, S, Laviña, B, Offermanns, S, Brakebusch, C & Betsholtz, C 2019, ' Adgrf5 contributes to patterning of the endothelial deep layer in retina ', Angiogenesis, vol. 22, no. 4, pp. 491-505 . https://doi.org/10.1007/s10456-019-09674-0

Neovascularization of the inner retinal space is a major cause of vision loss. In retinal angiomatous proliferation (RAP) syndrome, newly formed vessels originate from the retinal plexus and invade the inner retinal space. However, the molecular path

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dfa84b3bc1b6d6dc48e2a0a3cc577a0
https://doi.org/10.1007/s10456-019-09674-0

Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss

Autor: Amaury Cazenave-Gassiot, David L. Silver, Susan E. Quaggin, Maarja Andaloussi Mäe, Bàrbara Laviña, Elisa Vazquez-Liebanas, Bongnam Jung, Juat Chin Foo, Marie Jeansson, Annika Keller, Yvette Zarb, Michael Vanlandewijck, Markus R. Wenk, Liqun He, Khayrun Nahar, Chengua Gu, Bryan C. Tan, Eugene C. Butcher, Sofia Nordling, Christer Betsholtz, Xidan Li

Publikováno v: Circulation Research

Rationale: Pericytes are capillary mural cells playing a role in stabilizing newly formed blood vessels during development and tissue repair. Loss of pericytes has been described in several brain disorders, and genetically induced pericyte deficiency

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::264129839b6a627479da7aa593cec962
https://doi.org/10.5167/uzh-196164