Zobrazeno 1 - 10
of 3 029
pro vyhledávání: '"B, Yaffe"'
Autor:
Bert van de Kooij, Fenna J. van der Wal, Magdalena B. Rother, Wouter W. Wiegant, Pau Creixell, Merula Stout, Brian A. Joughin, Julia Vornberger, Matthias Altmeyer, Marcel A. T. M. van Vugt, Michael B. Yaffe, Haico van Attikum
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract During the repair of interstrand crosslinks (ICLs) a DNA double-strand break (DSB) is generated. The Fanconi anemia (FA) core complex, which is recruited to ICLs, promotes high-fidelity repair of this DSB by homologous recombination (HR). Ho
Externí odkaz:
https://doaj.org/article/8089b7910a9a4e0b88480d0ad31ef39a
Autor:
Michela Chiappa, Alessandra Decio, Luca Guarrera, Ilaria Mengoli, Anju Karki, Divora Yemane, Carmen Ghilardi, Eugenio Scanziani, Simone Canesi, Maria C. Barbera, Ilaria Craparotta, Marco Bolis, Robert Fruscio, Chiara Grasselli, Tommaso Ceruti, Massimo Zucchetti, Jesse C. Patterson, Robin A. Lu, Micheal B. Yaffe, Maya Ridinger, Giovanna Damia, Federica Guffanti
Publikováno v:
Cell Death and Disease, Vol 15, Iss 7, Pp 1-11 (2024)
Abstract Occurrence of resistance to olaparib, a poly(ADP-ribose) polymerase (PARP) inhibitor (PARPi) approved in ovarian carcinoma, has already been shown in clinical settings. Identifying combination treatments to sensitize tumor cells and/or overc
Externí odkaz:
https://doaj.org/article/e764c5cee5904b2eb21c09d037806e4a
Autor:
Ting Dong, Guangan Hu, Zhongqi Fan, Huirui Wang, Yinghui Gao, Sisi Wang, Hao Xu, Michael B. Yaffe, Matthew G. Vander Heiden, Guoyue Lv, Jianzhu Chen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Kupffer cells are liver resident macrophages and play critical role in fatty liver disease, yet the underlying mechanisms remain unclear. Here, we show that activation of G-protein coupled receptor 3 (GPR3) in Kupffer cells stimulates glycol
Externí odkaz:
https://doaj.org/article/83d25661a3af40cb9b261bb33f972632
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Correct repair of broken DNA molecules is required to prevent potentially oncogenic mutations. To study repair fidelity and mechanism, van de Kooij et al. developed single cell reporters that detect if DNA breaks are fixed by error-free or mutagenic
Externí odkaz:
https://doaj.org/article/5328c2a374704804ac90d26212e293eb
Autor:
Justine R. Stehn, Scott R. Floyd, Erik W. Wilker, H. Christian Reinhardt, Scott M. Clarke, Qiuying Huang, Roberto D. Polakiewicz, Nahum Sonenberg, Yi Wen Kong, Michael B. Yaffe
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
14-3-3 proteins play critical roles in controlling multiple aspects of the cellular response to stress and DNA damage including regulation of metabolism, cell cycle progression, cell migration, and apoptotic cell death by binding to protein substrate
Externí odkaz:
https://doaj.org/article/a76d35ddc948487f896db3bbbe2880e5
Publikováno v:
Molecular & Cellular Oncology, Vol 9, Iss 1 (2022)
Inducing immunogenic tumor cell death to stimulate the response to immune checkpoint blockade has not yet been effectively translated into clinical practice. We recently discovered that stressed/injured but still viable tumor cells are critical for T
Externí odkaz:
https://doaj.org/article/16b9badbd14c48bc8d2facda7cd7ee42
Autor:
Hunter B. Moore, MD, PhD, Matthew D. Neal, MD, Marnie Bertolet, PhD, Brian A. Joughin, PhD, Michael B. Yaffe, MD, PhD, Christopher D. Barrett, MD, Molly A. Bird, BS, Russell P. Tracy, PhD, Ernest E Moore, MD, Jason L. Sperry, MD, Brian S. Zuckerbraun, MD, Myung S. Park, MD, Mitchell J. Cohen, MD, Stephen R. Wisniewski, PhD, James H. Morrissey, PhD, TACTIC Investigators
Publikováno v:
Annals of Surgery Open, Vol 3, Iss 2, p e167 (2022)
Objective:. Trauma-induced coagulopathy (TIC) is provoked by multiple mechanisms and is perceived to be one driver of massive transfusions (MT). Single laboratory values using prothrombin time (INR) or thrombelastography (TEG) are used to clinically
Externí odkaz:
https://doaj.org/article/99cb90e1cb8743f7a15129fd3f2eac4c
Autor:
Joon Ho Kang, Georgios Katsikis, Zhaoqi Li, Kiera M. Sapp, Max A. Stockslager, Daniel Lim, Matthew G. Vander Heiden, Michael B. Yaffe, Scott R. Manalis, Teemu P. Miettinen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
ATP drives most cellular processes, although ATP production and consumption levels during mitosis remain unreported. Here, the authors combine metabolic measurements and modeling to quantify ATP levels and synthesis dynamics, revealing that ATP synth
Externí odkaz:
https://doaj.org/article/7d36fb2261454301970a2d8ba6a0530b
Autor:
Fred C. Lam, Yi Wen Kong, Qiuying Huang, Tu-Lan Vu Han, Amanda D. Maffa, Ekkehard M. Kasper, Michael B. Yaffe
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
In order to avoid transcription-replication conflicts (TRCs) on shared DNA templates, cell must maintain strict spatiotemporal co-ordination of transcription with replication. Here the authors uncover a role for BRD4 in preventing TRCs and DNA damage
Externí odkaz:
https://doaj.org/article/f6a993f462d34f85a100211de5c5cdd7
Autor:
Yi Wen Kong, Erik C. Dreaden, Sandra Morandell, Wen Zhou, Sanjeev S. Dhara, Ganapathy Sriram, Fred C. Lam, Jesse C. Patterson, Mohiuddin Quadir, Anh Dinh, Kevin E. Shopsowitz, Shohreh Varmeh, Ömer H. Yilmaz, Stephen J. Lippard, H. Christian Reinhardt, Michael T. Hemann, Paula T. Hammond, Michael B. Yaffe
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Cell cycle checkpoint kinase, MK2, is in synthetic relationship with p53 in the DNA damage response to chemotherapeutic agents. Here, the authors report XPA as a third gene in which simultaneous targeting of MK2 and XPA further enhances sensitivity t
Externí odkaz:
https://doaj.org/article/968af14e7f93410d8098ad17f0bc993d