Zobrazeno 1 - 10
of 489
pro vyhledávání: '"B, Wiggert"'
Autor:
Charles F. Thomas, Wendy L. Picking, R. Krishnan Kutty, William S. Stark, Kyuhwan Shim, B. Wiggert
Publikováno v:
Experimental Eye Research. 65:717-727
In Drosophila, thorough retinoid deprivation is possible, optimizing investigation of the effects of vitamin A metabolites and retinoic acid on the visual system. Retinoids had been found to control transcription and translation of Drosophila's opsin
Publikováno v:
The Journal of Immunology. 159:1004-1011
This study examines whether genetic susceptibility vs resistance to experimental autoimmune uveoretinitis (EAU) in mice is associated with dominant type 1 vs type 2 cytokine response profiles. Mice from six strains were immunized with the uveitogenic
Publikováno v:
The Journal of Immunology. 158:5997-6005
Experimental autoimmune uveitis (EAU) is a T cell-mediated disease that targets the neural retina and serves as a model of human uveitis. Uveitogenic effector T cells have a Th1-like phenotype (high IFN-gamma, low IL-4), and genetic susceptibility to
Publikováno v:
Human Immunology. 53:188-194
The major histocompatibility complex (MHC) gene, HLA-B27 is strongly associated with auto-immune uveitis and spondyloarthropathies in humans. Experimental mouse models of autoimmune uveitis involve systemic immunization with the retinal autoantigen i
Publikováno v:
Biochemical and Biophysical Research Communications. 215:386-393
Human retinal pigment epithelial (RPE) cells in culture respond to a mixture of cytokines (IFN-gamma, IL-1 beta, TNF-alpha) by producing large amounts of nitric oxide. Transforming growth factor-beta, unlike other growth factors, was found to inhibit
Autor:
S Shivaram, Gerald J. Chader, G Kutty, R K Kutty, D T Organisciak, B Wiggert, Paul Wong, R M Darrow, R T Fletcher
Publikováno v:
Biochemistry and Cell Biology. 72:499-503
Prolonged periods of high-intensity visible light exposure lead to photoreceptor cell degeneration, but the mechanism of damage is not understood. Increased clusterin mRNA levels have been found in several models of apoptosis, as well as in neurodege
Publikováno v:
Biochemical and Biophysical Research Communications. 204:799-806
Peptide 1169-1191 is a major uveitopathogenic determinant of bovine Interphotoreceptor Retinoid Binding Protein (IRBP) in Lewis rats. Previously, we identified two proteins with approximate molecular masses of 72 and 74 kDa and one with a molecular m
Autor:
R R Caspi, C C Chan, B G Grubbs, P B Silver, B Wiggert, C F Parsa, S Bahmanyar, A Billiau, H Heremans
Publikováno v:
The Journal of Immunology. 152:890-899
Locally produced IFN-gamma has been implicated in enhancing inflammation and in promoting organ-specific autoimmunity. In the present study, we investigated the influence of systemically available IFN-gamma on the expression of experimental autoimmun
Autor:
Todd Duncan, B. Wiggert, Jing-Sheng Si, John M. Nickerson, Geetha Kutty, T. van Veen, Gerald J. Chader
Publikováno v:
Experimental Eye Research. 58:65-75
Ambient light appears to play a role in regulating gene and protein expression of interphotoreceptor retinoid-binding protein (IRBP), a protein that facilitates the transport of retinoids between the neural retina and pigment epithelium in the visual
Publikováno v:
The Journal of Immunology. 148:2384-2389
Experimental autoimmune uveoretinitis (EAU) in animals is a T cell-mediated autoimmune response directed against cells of the neural retina, in particular the photoreceptors. EAU can be induced in susceptible strains of mice by immunization with puri