Codon optimization and improved delivery/immunization regimen enhance the immune response against wild-type and drug-resistant HIV-1 reverse transcriptase, preserving its Th2-polarity

Autor: A. A. Latanova, S. Petkov, A. Kilpelainen, J. Jansons, O. E. Latyshev, Y. V. Kuzmenko, J. Hinkula, M. A. Abakumov, V. T. Valuev-Elliston, M. Gomelsky, V. L. Karpov, F. Chiodi, B. Wahren, D. Y. Logunov, E. S. Starodubova, M. G. Isaguliants

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-22 (2018)

Abstract DNA vaccines require a considerable enhancement of immunogenicity. Here, we optimized a prototype DNA vaccine against drug-resistant HIV-1 based on a weak Th2-immunogen, HIV-1 reverse transcriptase (RT). We designed expression-optimized gene

Externí odkaz: https://doaj.org/article/1b38b6e3c64d4d089d2e1bc152026848

The EPIICAL project: an emerging global collaboration to investigate immunotherapeutic strategies in HIV-infected children

Autor: P. Palma, C. Foster, P. Rojo, P. Zangari, A. Yates, N. Cotugno, N. Klein, K. Luzuriaga, S. Pahwa, E. Nastouli, D.M. Gibb, W. Borkowsky, S. Bernardi, V. Calvez, E. Manno, Nadia Mora, A. Compagnucci, B. Wahren, M.Á Muñoz-Fernández, A. De Rossi, J. Ananworanich, D. Pillay, C. Giaquinto, P. Rossi

Publikováno v: Journal of Virus Eradication, Vol 1, Iss 3, Pp 134-139 (2015)

ABSTRACT: Short summary: The EPIICAL (Early-treated Perinatally HIV-infected Individuals: Improving Children's Actual Life with Novel Immunotherapeutic Strategies) project arises from the firm belief that perinatally infected children treated with su

Externí odkaz: https://doaj.org/article/368c227436ce422f9267890069592060

HIV pathogenesis and immunity (PP-074)

Autor: S. Kutscher, L. W. Thørner, K. Kobayashi, S. Tcheung, S. D. Mahajan, L. Díaz Muñoz, M. Baseler, V. Erfle, M. T. M. Giret, P. M. Mwimanzi, C. Vandergeeten, C. Lane, I. I. Generalov, T. Amet, L. H. Harritshøj, M. Leal Noval, R. Aalinkeel, C. Erikstrup, R. Tanaka, S. J. Kent, I. Mangeot-Méderlé, K. Nayak, L. Gudmundsdotter, Z. Bernstein, M. Takiguchi, J. Hinkula, S. Hu, S. E. Johansson, A. Iwamoto, Shafiqur Rahman, N. Singh, J. L. Reynolds, Z. Nan, M. Moutschen, A. Corneau, S. Watanabe, T. Friesen, A. Kawana-Tachikawa, D. Byrd, H. Fausther-Bovendo, S. Sammicheli, P. Tantivorasit, K. Kärre, M. Takeda, M. Ishige, R. Davey, Elbert Reyes, S. Sharma, M. Ghabril, K. Ruxrungtham, M. Kannagi, T. Fujii, S. Allgayer, S. Subramanayam, T. A. Parhomenko, M. Raska, Sajib Chakraborty, H. Ullum, P. Debré, Q. Yu, S. Brighenti, J. Andersson, C. Thielen, J. Chandrabose, A. García Torre, J. Martinez, B. Saha, J. D. Rosales, M. Vajpayee, N. Ahmed, L. Berg, B. Wahren, M. Svensson, K. Imai, S. Rahmouni, J. D. Lifson, T. Miura, Y. Takahashi, N. Mehra, N. Tachikawa, C. Gilbert, R. C. Succi, S. Grutzmeier, H. Furukawa, P. Chatkulkawin, R. Brown, A. Busca, V. Vieillard, T. Chikata, Z. I. Akhmedjanova, H. Nakamura, M. C. Elliott, J. Adams, N. Obel, S. Hall, A. W. Chung, K. Honda, T. Masuda, K. Ochiai, E. M. Shankar, G. Roby, A. Shajiei, J. Adelsberger, S. A. Schwartz, M. Hashimoto, D. Hoffmann, T. Okamoto, C. Wilhelm, M. Singh, E. S. Odintsova, S. Nowroozalizadeh, K. Nakayama, C. J. Dembek, S. Sirivichayakul, Y. Mitsuki, M. J. Tremblay, S. Swaminathan, M. Larsson, S. Bayanolhagh, P. Singh, M. Tamura, K. Shibusawa, Y. Tamura, Melisa Colmenares, T. Ueno, V. N. Buneva, H. Gatanaga, Darrell L. Peterson, A. Hasegawa, S. Buranapraditkun, E. Rollman, Ashish Kumar, Y. Suzuki, N. Vivar, Aneesa Ansari, P. Ammaranond, H. Gaines, K. Sakai, Henry Montes, R. Le Grand, Y. Tanaka, A. Agosto-Mojica, G. A. Nevinsky, D. F. Nixon, M. Saxena, H. Park, B. Réthi, L. Czernekova, I. Stratov, Z. Moldoveanu, M. Jansson, F. Chiodi, Siham Salmen, J. Mestecky, M. Proschan, E. G. Kallas, M. Catalfamo, N. Dereuddre-Bosquet, M. Muñoz Fernández, G. Kaur, D. E. Sykes, T. Chida, K. Terahara, Y. Kiyoshi, N. Chalasani, C. J. Gouveia, A. Cosma, N. Ruffin, Lisbeth Berrueta, C. Rehm, C. Hsiao, Y. Yanagi, B. M. Ali, K. F. Che, S. Oka, Y. Tsunetsugu-Yokota, F. Maldarelli, N. Okamura, T. Koibuchi, R. Correa Rocha, A. A. Lambert, J. Novak, L. P. Sizyakina, S. Okada, Mustafizur Rahman, L. E. Hanna, L. Andersson, B. B. Nair, K. Zachova, F. D. Goebel, E. Sandström, J. R. Bogner, B. Hejdeman, T. Hayashi, G. Sharma

Publikováno v: International Immunology. 22:iv63-iv69

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::791b0bdb5f2e741a4589ab42a0c6d408
https://doi.org/10.1093/intimm/dxq254

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Pre-clinical evaluation of a CEA DNA prime/protein boost vaccination strategy against colorectal cancer

Autor: K, Hallermalm, S, Johansson, A, Bråve, M, Ek, G, Engström, A, Boberg, L, Gudmundsdotter, P, Blomberg, H, Mellstedt, R, Stout, M A, Liu, B, Wahren

Publikováno v: Scandinavian journal of immunology. 66(1)

In preparation for a clinical trial in patients diagnosed with colorectal cancer, a vaccination strategy targeting the carcinoembryonic antigen (CEA) was evaluated in mice using a GMP-produced plasmid DNA vaccine, CEA66, encoding a truncated form of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ed8846d39cf01f1a07663ede51c0621d
https://pubmed.ncbi.nlm.nih.gov/17587345