Immunization with matrix-, nucleoprotein and neuraminidase protects against H3N2 influenza challenge in pH1N1 pre-exposed pigs

Autor: Eleni Vatzia, Katherine Feest, Adam McNee, Tanuja Manjegowda, B. Veronica Carr, Basudev Paudyal, Tiphany Chrun, Emmanuel A. Maze, Amy Mccarron, Susan Morris, Helen E. Everett, Ronan MacLoughlin, Francisco J. Salguero, Teresa Lambe, Sarah C. Gilbert, Elma Tchilian

Publikováno v: npj Vaccines, Vol 8, Iss 1, Pp 1-14 (2023)

Abstract There is an urgent need for influenza vaccines providing broader protection that may decrease the need for annual immunization of the human population. We investigated the efficacy of heterologous prime boost immunization with chimpanzee ade

Externí odkaz: https://doaj.org/article/360ba21cac734dc29a1a9ee1b34725d4

Immunization with matrix-, nucleoprotein and neuraminidase protects against H3N2 influenza challenge in pH1N1 pre-exposed pigs

Autor: Eleni Vatzia, Katherine Feest, Adam McNee, Tanuja Manjegowda, B Veronica Carr, Basu Pauday, Tiphany Chrun, Emmanuel Maze, Susan Morris, Helen Everett, Ronan MacLoughlin, Francisco Salguero, Teresa Lambe, Sarah Gilbert, Elma Tchilian

There is an urgent need for influenza vaccines providing broader protection that may decrease the need for annual immunization. We investigated the efficacy of heterologous prime boost immunization with chimpanzee adenovirus (ChAdOx2) and modified va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::479ed853f4c85f3fdcab16b6382b392c
https://doi.org/10.21203/rs.3.rs-2062602/v1

The B-cell response to foot-and-mouth-disease virus in cattle following vaccination and live-virus challenge

Autor: Simon Gubbins, Bryan Charleston, Catherine Elisabeth Charreyre, Nagendrakumar Balasubramanian Singanallur, Jacqueline Morris, Clare F. J. Grant, Wilna Vosloo, Pascal Hudelet, Martin Ilott, B. Veronica Carr

Publikováno v: The Journal of General Virology

Antibodies play a pivotal role against viral infection, and maintenance of protection is dependent on plasma and memory B-cells. Understanding antigen-specific B-cell responses in cattle is essential to inform future vaccine design. We have previousl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06955d73697bd1bde32df3a1b987a5c6
https://doi.org/10.1099/jgv.0.000517

Distinct immune responses and virus shedding in pigs following aerosol, intra-nasal and contact infection with pandemic swine influenza A virus, A(H1N1)09

Autor: Mick Bailey, Elma Tchilian, Laetitia Canini, Katy E. Beck, Francisco J. Salguero, Sharon M. Brookes, Mark E. J. Woolhouse, Helen Everett, Ian H. Brown, Bryan Charleston, Ronan Mac Loughlin, B. Veronica Carr, Johanneke D. Hemmink, Margo Chase-Topping, Sophie B. Morgan, Emily Porter, Mario Aramouni

Publikováno v: Veterinary Research
Veterinary Research, BioMed Central, 2016, 47 (1), pp.103. ⟨10.1186/s13567-016-0390-5⟩
Hemmink, J, Morgan, S, Aramouni, M, Everett, H, Salguero, F, Canini, L, Porter, E, Chase-Topping, M, Beck, K, Mac Loughlin, R, Carr, B V, brown, I, Bailey, M, Woolhouse, M, Brookes, S, Charleston, B & Tchilian, E 2016, ' Distinct immune responses and virus shedding in pigs following aerosol, intra-nasal and contact infection with pandemic swine influenza A virus, A(H1N1)09 ', Veterinary Research, vol. 47, no. 103 . https://doi.org/10.1186/s13567-016-0390-5
Hemmink, H, Morgan, S B, Aramouni, M, Everett, H, Salguero, F J, Canini, L, Porter, E, Chase-Topping, M, Beck, K, Loughlin, R M, Carr, B V, Brown, I H, Bailey, M, Woolhouse, M, Brookes, S M, Charleston, B & Tchilian, E 2016, ' Distinct immune responses and virus shedding in pigs following aerosol, intra-nasal and contact infection with pandemic swine influenza A virus, A(H1N1)09 ', Veterinary Research, vol. 47, no. 1, 103 . https://doi.org/10.1186/s13567-016-0390-5

Influenza virus infection in pigs is a major farming problem, causing considerable economic loss and posing a zoonotic threat. In addition the pig is an excellent model for understanding immunity to influenza viruses as this is a natural host pathoge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6154373e1960b180a75c32e0759fd268
https://hal.archives-ouvertes.fr/hal-01390764

Workshop cluster 1, a γδ T cell specific receptor is phosphorylated and down regulated by activation induced Src family kinase activity

Autor: Eric A. Lefevre, Meenu R. Pillai, Bryan Charleston, Pauline O'Grady, B. Veronica Carr

Publikováno v: Molecular Immunology. 44:1691-1703

Workshop cluster 1(+) gamma delta (WC1(+)gammadelta) T cells have been shown to play important roles in the immune response to infections. WC1 is a transmembrane glycoprotein, uniquely expressed on the surface of gammadelta T cells of ruminants and p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a921b77dc9ddc73aeff61445f79355
https://doi.org/10.1016/j.molimm.2006.08.009