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Inflammation increases oxidative DNA damage repair and stimulates preneoplastic changes in colons of newborn rats

Autor: P, Kowalczyk, J, Jaworek, M, Kot, B, Sokolowska, A, Bielen, B, Janowska, J M, Ciesla, G, Szparecki, B, Sados, B, Tudek

Publikováno v: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 67(2)

Oxidative DNA damage may be a risk factor for development of various pathologies, including malignancy. We studied inflammation triggered modulation of repair activity in the intestines of three weeks old rats injected i.p. with E.coli or S. typhimur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2def9c76daafd667dc352d40357a70d1
https://pubmed.ncbi.nlm.nih.gov/27226187

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Escherichia coli Fpg protein and UvrABC endonuclease repair DNA damage induced by methylene blue plus visible light in vivo and in vitro

Autor: B Lambert, H Czeczot, Jacques Laval, B Tudek, Serge Boiteux

Publikováno v: Journal of Bacteriology. 173:3419-3424

pBR322 plasmid DNA was treated with methylene blue plus visible light (MB-light) and tested for transformation efficiency in Escherichia coli mutants defective in either formamidopyrimidine-DNA glycosylase (Fpg protein) and/or UvrABC endonuclease. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b359a68f8b33291fca24e56fc67c571
https://doi.org/10.1128/jb.173.11.3419-3424.1991

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Modulation of oxidative DNA damage repair by the diet, inflammation and neoplastic transformation

Autor: B, Tudek, M, Swoboda, P, Kowalczyk, R, Oliński

Publikováno v: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 57

Oxidative DNA damage and DNA repair may mediate several cellular processes, like replication and transcription, mutagenesis and apoptosis and thus may be important for the organism development as well as its pathogenesis, including cancer. Activity o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::be8b9d186bd5a8e1a65f537a5f3ecefd
https://pubmed.ncbi.nlm.nih.gov/17228095

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Mutagenic specificity of imidazole ring-opened 7-methylpurines in M13mp18 phage DNA

Autor: B, Tudek, M, Graziewicz, O, Kazanova, T H, Zastawny, T, Obtułowicz, J, Laval

Publikováno v: Acta biochimica Polonica. 46(3)

The most abundant lesion formed in DNA upon modification with methylating agents 7-methylguanine, under alkaline conditions is converted into 2,6-diamino-4-hydroxy-5N-methyl-formamidopyrimidine (Fapy-7MeGua). We have previously shown that treatment o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::555f42e99a6759f8a34788f2090d583c
https://pubmed.ncbi.nlm.nih.gov/10698287

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Localization of chloroacetaldehyde-induced DNA damage in human p53 gene by DNA polymerase fingerprint analysis

Autor: B, Tudek, P, Kowalczyk, J M, Cieśla

Publikováno v: IARC scientific publications. (150)

Chloroacetaldehyde (CAA) reacts with DNA bases, forming hydroxyethano derivatives of different stability, which are subsequently converted into etheno (epsilon) adducts: epsilon A, epsilon C, epsilon G. DNA polymerase fingerprint analysis was used to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7d2045152d3c9b651dc2f42b892fc390
https://pubmed.ncbi.nlm.nih.gov/10626228

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