Zobrazeno 1 - 10
of 194
pro vyhledávání: '"B, Smaill"'
Autor:
Abigail V. Sharrock, Jeff S. Mumm, Elsie M. Williams, Narimantas Čėnas, Jeff B. Smaill, Adam V. Patterson, David F. Ackerley, Gintautas Bagdžiūnas, Vickery L. Arcus
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6593 (2024)
Bacterial nitroreductase enzymes capable of activating imaging probes and prodrugs are valuable tools for gene-directed enzyme prodrug therapies and targeted cell ablation models. We recently engineered a nitroreductase (E. coli NfsB F70A/F108Y) for
Externí odkaz:
https://doaj.org/article/35db6809fd4042d9882cc7c017640035
Autor:
Victoria Jackson-Patel, Emily Liu, Matthew R. Bull, Amir Ashoorzadeh, Gib Bogle, Anna Wolfram, Kevin O. Hicks, Jeff B. Smaill, Adam V. Patterson
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Hypoxia-activated prodrugs are bioactivated in oxygen-deficient tumour regions and represent a novel strategy to exploit this pharmacological sanctuary for therapeutic gain. The approach relies on the selective metabolism of the prodrug under patholo
Externí odkaz:
https://doaj.org/article/c34ba5238adc4eb49a0ab52ce8b13172
Autor:
Linda Spiegelberg, Ruud Houben, Raymon Niemans, Dirk de Ruysscher, Ala Yaromina, Jan Theys, Christopher P. Guise, Jeffrey B. Smaill, Adam V. Patterson, Philippe Lambin, Ludwig J. Dubois
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 15, Iss , Pp 62-69 (2019)
Hypoxia-activated prodrugs (HAPs) are designed to specifically target the hypoxic cells of tumors, which are an important cause of treatment resistance to conventional therapies. Despite promising preclinical and clinical phase I and II results, the
Externí odkaz:
https://doaj.org/article/75c6748e20a543519df6ae43fdf0f2f0
Autor:
Amir Ashoorzadeh, Alexandra M. Mowday, Christopher P. Guise, Shevan Silva, Matthew R. Bull, Maria R. Abbattista, Janine N. Copp, Elsie M. Williams, David F. Ackerley, Adam V. Patterson, Jeff B. Smaill
Publikováno v:
Pharmaceuticals, Vol 15, Iss 2, p 185 (2022)
PR-104A is a dual hypoxia/nitroreductase gene therapy prodrug by virtue of its ability to undergo either one- or two-electron reduction to its cytotoxic species. It has been evaluated extensively in pre-clinical GDEPT studies, yet off-target human al
Externí odkaz:
https://doaj.org/article/9dcd35635dfd4a64b8e3fee16b54111f
Autor:
Maria R. Abbattista, Amir Ashoorzadeh, Christopher P. Guise, Alexandra M. Mowday, Rituparna Mittra, Shevan Silva, Kevin O. Hicks, Matthew R. Bull, Victoria Jackson-Patel, Xiaojing Lin, Gareth A. Prosser, Neil K. Lambie, Gabi U. Dachs, David F. Ackerley, Jeff B. Smaill, Adam V. Patterson
Publikováno v:
Pharmaceuticals, Vol 14, Iss 12, p 1231 (2021)
PR-104 is a phosphate ester pre-prodrug that is converted in vivo to its cognate alcohol, PR-104A, a latent alkylator which forms potent cytotoxins upon bioreduction. Hypoxia selectivity results from one-electron nitro reduction of PR-104A, in which
Externí odkaz:
https://doaj.org/article/b19c86e2af6c49538c7e81a3e7b91af6
Autor:
Fang Yang, Xiaojuan Chen, Xiaojuan Song, Raquel Ortega, Xiaojing Lin, Wuqing Deng, Jing Guo, Zhengchao Tu, Adam V. Patterson, Jeff B. Smaill, Yongheng Chen, Xiaoyun Lu
Publikováno v:
Journal of Medicinal Chemistry. 65:14809-14831
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e9888b847d544d6fae1ee9fe909f276
https://doi.org/10.1021/acs.jmedchem.2c01319
https://doi.org/10.1021/acs.jmedchem.2c01319
Autor:
Yang Zhou, Hang Yu, Anna Constance Vind, Lulu Kong, Yiling Liu, Xiaojuan Song, Zhengchao Tu, Caihong Yun, Jeff B. Smaill, Qing-Wen Zhang, Ke Ding, Simon Bekker-Jensen, Xiaoyun Lu
Publikováno v:
Journal of Medicinal Chemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcde43e8e2979db0996a170ba2552695
https://doi.org/10.1021/acs.jmedchem.3c00088
https://doi.org/10.1021/acs.jmedchem.3c00088
Autor:
Ziad Omran, Chris P. Guise, Linwei Chen, Cyril Rauch, Ashraf N. Abdalla, Omeima Abdullah, Ikhlas A. Sindi, Peter M. Fischer, Jeff B. Smaill, Adam V. Patterson, Yuxiu Liu, Qingmin Wang
Publikováno v:
Molecules, Vol 26, Iss 11, p 3327 (2021)
Phenanthroindolizidines, such as antofine and tylophorine, are a family of natural alkaloids isolated from different species of Asclepiadaceas. They are characterized by interesting biological activities, such as pronounced cytotoxicity against diffe
Externí odkaz:
https://doaj.org/article/c9e24773f32e4df19e750c5e5c98a534
Autor:
Robert C. Doebele, Stephen V. Liu, Chul Kim, Adam V. Patterson, Jeff B. Smaill, Matthew R. Bull, Shevan Silva, Vijaya G. Tirunagaru, Andrea E. Doak, Anh T. Le, Adriana Estrada-Bernal
Representation of tarloxotinib conversion to its irreversible EGFR/HER2 inhibitor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00fb642c5c8e27d132f13b95faa65d12
https://doi.org/10.1158/1078-0432.22478582.v1
https://doi.org/10.1158/1078-0432.22478582.v1
Autor:
Robert C. Doebele, Stephen V. Liu, Chul Kim, Adam V. Patterson, Jeff B. Smaill, Matthew R. Bull, Shevan Silva, Vijaya G. Tirunagaru, Andrea E. Doak, Anh T. Le, Adriana Estrada-Bernal
Supplemental table 2. Tarloxotinib-E inhibition of the ErbB family using biochemical kinase assays
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::801ef129db5c6e8a2e344c4aa005933a
https://doi.org/10.1158/1078-0432.22478555.v1
https://doi.org/10.1158/1078-0432.22478555.v1