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Publikováno v:
British Journal of Clinical Pharmacology. 46:363-367
Aims The aim of this study was to determine the potential impact of age on the pharmacokinetics of temocapril and its pharmacologically active diacid metabolite, temocaprilat, in hypertensive patients. Methods Male and female patients with mild to mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5416d347536127bcd460b6ed34841a3
https://doi.org/10.1046/j.1365-2125.1998.t01-1-00785.x
https://doi.org/10.1046/j.1365-2125.1998.t01-1-00785.x
Publikováno v:
British journal of clinical pharmacology. 46(4)
The aim of this study was to determine the potential impact of age on the pharmacokinetics of temocapril and its pharmacologically active diacid metabolite, temocaprilat, in hypertensive patients.Male and female patients with mild to moderate essenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f64130712b9d36fcd97b99fc37c4b135
https://pubmed.ncbi.nlm.nih.gov/9803985
https://pubmed.ncbi.nlm.nih.gov/9803985
Autor:
A. T. J. Lavrijssen, Hans-Hellmut Neumayer, K. Püchler, B. Sierakowski, Lutz Fritsche, T. Thomsen, K. M. Eckl, Ivar Roots, K. Renneisen
Publikováno v:
British journal of clinical pharmacology. 44(6)
AIMS The aim of this study was to determine the potential influence of renal impairment on the pharmacokinetics of temocapril and its pharmacologically active diacid metabolite, temocaprilat. METHODS Non-compartmental pharmacokinetics were assessed i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f478e87dbbb8b0a949185c60287d8eb
https://pubmed.ncbi.nlm.nih.gov/9431827
https://pubmed.ncbi.nlm.nih.gov/9431827
Publikováno v:
European journal of clinical pharmacology. 53(3-4)
The aim of this study was to determine the influence of renal impairment on the single-dose pharmacokinetics of temocapril and its pharmacologically active metabolite, temocapril diacid.A single oral dose of 20 mg temocapril hydrochloride was given a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15c91ff07cb7e98329511832d0fe89e2
https://pubmed.ncbi.nlm.nih.gov/9476034
https://pubmed.ncbi.nlm.nih.gov/9476034
Publikováno v:
Medizinische Klinik (Munich, Germany : 1983). 89(8)
Spirapril is a recent ACE inhibitor with a both renal and hepatic elimination pathway. In order to determine its tolerability, primarily the impact on renal function, Spirapril was tested in a single-blind trial with a 2-week placebo run-in phase and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c0368f17013981ecb8c8935ce233c03f
https://pubmed.ncbi.nlm.nih.gov/7968874
https://pubmed.ncbi.nlm.nih.gov/7968874
Publikováno v:
Blood pressure. Supplement. 2
In this single-blind trial with a 2-week placebo run-in followed by a 4-week active-treatment period, patients were given 6 mg of spirapril once daily. Forty-nine hypertensive men and women were recruited; all had pretreatment diastolic blood pressur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2d699a094c686f48a460faf9066d471f
https://pubmed.ncbi.nlm.nih.gov/8061846
https://pubmed.ncbi.nlm.nih.gov/8061846
Publikováno v:
Blood pressure. Supplement. 2
A total of 171 male and female patients with mild-to-moderate hypertension [diastolic blood pressure (DBP) 100-115 mmHg] entered this randomized, double-blind, multicentre study. A 3-week placebo run-in period was followed by a 5-week active-treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7deec03ed3a02fd31b20d47bb56f408d
https://pubmed.ncbi.nlm.nih.gov/8061845
https://pubmed.ncbi.nlm.nih.gov/8061845
Publikováno v:
Blood pressure. Supplement. 2
In a single-blind trial with a 2-week placebo run-in phase and a 4-week active-treatment period, spirapril at 6 mg once daily was administered to 49 consecutive hypertensive patients (34 men and 15 women). All had pretreatment diastolic blood pressur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::585be61ddcc0c9850f6ce43f0417b221
https://pubmed.ncbi.nlm.nih.gov/8061847
https://pubmed.ncbi.nlm.nih.gov/8061847
Publikováno v:
Blood pressure. Supplement. 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3d7e006a6f5088aa3bc585f841ac4454
https://pubmed.ncbi.nlm.nih.gov/8061856
https://pubmed.ncbi.nlm.nih.gov/8061856