Zobrazeno 1 - 10
of 1 273
pro vyhledávání: '"B, Schiller"'
Autor:
Fabiola Curion, Xichen Wu, Lukas Heumos, Mylene Mariana Gonzales André, Lennard Halle, Matiss Ozols, Melissa Grant-Peters, Charlotte Rich-Griffin, Hing-Yuen Yeung, Calliope A. Dendrou, Herbert B. Schiller, Fabian J. Theis
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-22 (2024)
Abstract Single-cell multiplexing techniques (cell hashing and genetic multiplexing) combine multiple samples, optimizing sample processing and reducing costs. Cell hashing conjugates antibody-tags or chemical-oligonucleotides to cell membranes, whil
Externí odkaz:
https://doaj.org/article/42d6e98537b54ce08caa92cd642b91db
Autor:
Shruthi Kalgudde Gopal, Ruoxuan Dai, Ania Maria Stefanska, Meshal Ansari, Jiakuan Zhao, Pushkar Ramesh, Johannes W. Bagnoli, Donovan Correa-Gallegos, Yue Lin, Simon Christ, Ilias Angelidis, Valerio Lupperger, Carsten Marr, Lindsay C. Davies, Wolfgang Enard, Hans-Günther Machens, Herbert B. Schiller, Dongsheng Jiang, Yuval Rinkevich
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The origins of wound myofibroblasts and scar tissue remains unclear, but it is assumed to involve conversion of adipocytes into myofibroblasts. Here, we directly explore the potential plasticity of adipocytes and fibroblasts after skin injur
Externí odkaz:
https://doaj.org/article/555bd59cdc42402d93754aed435aa3b6
Autor:
Francesca Calicchio, Lisa J. Lim, Danielle Cross, Dwight Bibby, Qizhi Fang, Karl Meisel, Nelson B. Schiller, Francesca N. Delling
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
Background and purposeMitral valve prolapse (MVP) has been associated with an increased risk of ischemic stroke. Older age, thicker mitral leaflets, and significant mitral regurgitation (MR) leading to atrial fibrillation have been traditionally cons
Externí odkaz:
https://doaj.org/article/062e499b2bd44f93984a36efc52d5109
Autor:
Theodore S. Kapellos, Kevin Baßler, Wataru Fujii, Christina Nalkurthi, Anna C. Schaar, Lorenzo Bonaguro, Tal Pecht, Izabela Galvao, Shobhit Agrawal, Adem Saglam, Erica Dudkin, Amit Frishberg, Elena de Domenico, Arik Horne, Chantal Donovan, Richard Y. Kim, David Gallego-Ortega, Tessa E. Gillett, Meshal Ansari, Jonas Schulte-Schrepping, Nina Offermann, Ignazio Antignano, Burcu Sivri, Wenying Lu, Mathew S. Eapen, Martina van Uelft, Collins Osei-Sarpong, Maarten van den Berge, Hylke C. Donker, Harry J.M. Groen, Sukhwinder S. Sohal, Johanna Klein, Tina Schreiber, Andreas Feißt, Ali Önder Yildirim, Herbert B. Schiller, Martijn C. Nawijn, Matthias Becker, Kristian Händler, Marc Beyer, Melania Capasso, Thomas Ulas, Jan Hasenauer, Carmen Pizarro, Fabian J. Theis, Philip M. Hansbro, Dirk Skowasch, Joachim L. Schultze
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112525- (2023)
Summary: Systemic inflammation is established as part of late-stage severe lung disease, but molecular, functional, and phenotypic changes in peripheral immune cells in early disease stages remain ill defined. Chronic obstructive pulmonary disease (C
Externí odkaz:
https://doaj.org/article/de07677bc6c241f3a6d5cd66f2c12fd0
Autor:
Gizem Günes Günsel, Thomas M. Conlon, Aicha Jeridi, Rinho Kim, Zeynep Ertüz, Niklas J. Lang, Meshal Ansari, Mariia Novikova, Dongsheng Jiang, Maximilian Strunz, Mariia Gaianova, Christine Hollauer, Christina Gabriel, Ilias Angelidis, Sebastian Doll, Jeanine C. Pestoni, Stephanie L. Edelmann, Marlene Sophia Kohlhepp, Adrien Guillot, Kevin Bassler, Hannelore P. Van Eeckhoutte, Özgecan Kayalar, Nur Konyalilar, Tamara Kanashova, Sophie Rodius, Carolina Ballester-López, Carlos M. Genes Robles, Natalia Smirnova, Markus Rehberg, Charu Agarwal, Ioanna Krikki, Benoit Piavaux, Stijn E. Verleden, Bart Vanaudenaerde, Melanie Königshoff, Gunnar Dittmar, Ken R. Bracke, Joachim L. Schultze, Henrik Watz, Oliver Eickelberg, Tobias Stoeger, Gerald Burgstaller, Frank Tacke, Vigo Heissmeyer, Yuval Rinkevich, Hasan Bayram, Herbert B. Schiller, Marcus Conrad, Robert Schneider, Ali Önder Yildirim
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Chronic obstructive pulmonary disease is a progressive and incurable chronic condition that involves accumulation of inflammatory macrophages in the lung tissue. Authors here show in mouse models of lung disease that PRMT7, a protein arginine methylt
Externí odkaz:
https://doaj.org/article/a84378847bdf46488a490ed2e06676b9
Autor:
Barbara Spix, Elisabeth S. Butz, Cheng-Chang Chen, Anna Scotto Rosato, Rachel Tang, Aicha Jeridi, Veronika Kudrina, Eva Plesch, Philipp Wartenberg, Elisabeth Arlt, Daria Briukhovetska, Meshal Ansari, Gizem Günes Günsel, Thomas M. Conlon, Amanda Wyatt, Sandra Wetzel, Daniel Teupser, Lesca M. Holdt, Fabien Ectors, Ingrid Boekhoff, Ulrich Boehm, Jaime García-Añoveros, Paul Saftig, Martin Giera, Sebastian Kobold, Herbert B. Schiller, Susanna Zierler, Thomas Gudermann, Christian Wahl-Schott, Franz Bracher, Ali Önder Yildirim, Martin Biel, Christian Grimm
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Excess macrophage elastase MMP-12 is a major driver of chronic obstructive pulmonary disease. Here the authors show that the endolysosomal ion channel TRPML3 is a regulator of the cellular reuptake of MMP-12, thus neutralizing harmful MMP-12 in the l
Externí odkaz:
https://doaj.org/article/7d029bd581f74fcaa96bcacc1faef5b8
Autor:
Jacqueline T. DesJardin, Yana Svetlichnaya, Nicholas A. Kolaitis, Steven R. Hays, Jasleen Kukreja, Nelson B. Schiller, Lucas S. Zier, Jonathan P. Singer, Teresa De Marco
Publikováno v:
Pulmonary Circulation, Vol 13, Iss 1, Pp n/a-n/a (2023)
Abstract Noninvasive assessment of pulmonary hemodynamics is often performed by echocardiographic estimation of the pulmonary artery systolic pressure (ePASP), despite limitations in the advanced lung disease population. Other noninvasive hemodynamic
Externí odkaz:
https://doaj.org/article/b12b90c63add41f6a19965d127ea30a5
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 17 (2022)
Background Systemic vascular resistance (SVR) is an integral component of the hemodynamic profile. Previous studies have demonstrated a close correlation between an estimated SVR analog (eSVR) based on echocardiographic methods and SVR by direct hemo
Externí odkaz:
https://doaj.org/article/0f814b48bc004d318da4413033ce0f43
Autor:
David S. Fischer, Meshal Ansari, Karolin I. Wagner, Sebastian Jarosch, Yiqi Huang, Christoph H. Mayr, Maximilian Strunz, Niklas J. Lang, Elvira D’Ippolito, Monika Hammel, Laura Mateyka, Simone Weber, Lisa S. Wolff, Klaus Witter, Isis E. Fernandez, Gabriela Leuschner, Katrin Milger, Marion Frankenberger, Lorenz Nowak, Katharina Heinig-Menhard, Ina Koch, Mircea G. Stoleriu, Anne Hilgendorff, Jürgen Behr, Andreas Pichlmair, Benjamin Schubert, Fabian J. Theis, Dirk H. Busch, Herbert B. Schiller, Kilian Schober
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
High resolution characterisation of the virus specific T cell response to SARS CoV2 provides further understanding to the immune response to the infection. Here the authors apply a reverse phenotyping approach to interrogate the SARS-CoV-2 T cell com
Externí odkaz:
https://doaj.org/article/84508b147f414165a4d89699fa0e872a
Autor:
Dongsheng Jiang, Simon Christ, Donovan Correa-Gallegos, Pushkar Ramesh, Shruthi Kalgudde Gopal, Juliane Wannemacher, Christoph H. Mayr, Valerio Lupperger, Qing Yu, Haifeng Ye, Martin Mück-Häusl, Vijayanand Rajendran, Li Wan, Juan Liu, Ursula Mirastschijski, Thomas Volz, Carsten Marr, Herbert B. Schiller, Yuval Rinkevich
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Extensive scars develop in deep wounds as opposed to superficial wounds but it is unclear why. Here, the authors use live imaging of physiologic wounds and scars formed ex vivo to show that fascia fibroblasts upregulate N-cadherin allowing coordinate
Externí odkaz:
https://doaj.org/article/6eca455309404024a7a128b6fcc9370e