Zobrazeno 1 - 10
of 1 375
pro vyhledávání: '"B, Sauer"'
Autor:
Huanyu Z. Li, Ashley C. W. Pike, Irina Lotsaris, Gamma Chi, Jesper S. Hansen, Sarah C. Lee, Karin E. J. Rödström, Simon R. Bushell, David Speedman, Adam Evans, Dong Wang, Didi He, Leela Shrestha, Chady Nasrallah, Nicola A. Burgess-Brown, Robert J. Vandenberg, Timothy R. Dafforn, Elisabeth P. Carpenter, David B. Sauer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Proline is widely known as the only proteogenic amino acid with a secondary amine. In addition to its crucial role in protein structure, the secondary amino acid modulates neurotransmission and regulates the kinetics of signaling proteins. T
Externí odkaz:
https://doaj.org/article/32dcb0d22d77485888ff653efcd48c4e
Autor:
Qiansheng Liang, Gamma Chi, Leonardo Cirqueira, Lianteng Zhi, Agostino Marasco, Nadia Pilati, Martin J. Gunthorpe, Giuseppe Alvaro, Charles H. Large, David B. Sauer, Werner Treptow, Manuel Covarrubias
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Small-molecule modulators of diverse voltage-gated K+ (Kv) channels may help treat a wide range of neurological disorders. However, developing effective modulators requires understanding of their mechanism of action. We apply an orthogonal a
Externí odkaz:
https://doaj.org/article/cd3c8dd7577c4ee08657c1ab9f7f472d
Autor:
Daniela Digles, Alvaro Ingles-Prieto, Vojtech Dvorak, Tamara A. M. Mocking, Ulrich Goldmann, Andrea Garofoli, Evert J. Homan, Alberto Di Silvio, Lucia Azzollini, Francesca Sassone, Mario Fogazza, Felix Bärenz, Antje Pommereau, Yasmin Zuschlag, Jasper F. Ooms, Jeppe Tranberg-Jensen, Jesper S. Hansen, Josefina Stanka, Hubert J. Sijben, Helena Batoulis, Eckhard Bender, Riccardo Martini, Adriaan P. IJzerman, David B. Sauer, Laura H. Heitman, Vania Manolova, Juergen Reinhardt, Alexander Ehrmann, Philipp Leippe, Gerhard F. Ecker, Kilian V. M. Huber, Thomas Licher, Lia Scarabottolo, Tabea Wiedmer, Giulio Superti-Furga
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
With over 450 genes, solute carriers (SLCs) constitute the largest transporter superfamily responsible for the uptake and efflux of nutrients, metabolites, and xenobiotics in human cells. SLCs are associated with a wide variety of human diseases, inc
Externí odkaz:
https://doaj.org/article/d3ca8f18dbc2476ea3722a966b570ca6
Autor:
David B. Sauer, Jennifer J. Marden, Joseph C. Sudar, Jinmei Song, Christopher Mulligan, Da-Neng Wang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
DASS carboxylate transporters linked to metabolic diseases couple the Na+ gradient to nutrient uptake. Here, the authors unravel the structural basis by which Na+ binding coordinates substrate interactions, revealing a distinct coupling mechanism.
Externí odkaz:
https://doaj.org/article/91c93804bc594b8eab63527045308f23
Autor:
Roman O. Kowalchuk, MD, Kathryn M. Van Abel, MD, Adam B. Sauer, BS, Linda X. Yin, MD, Joaquin J. Garcia, MD, William S. Harmsen, MS, Eric J. Moore, MD, Daniel L. Price, MD, Ashish V. Chintakuntlawar, MD, Katharine R. Price, MD, Scott C. Lester, MD, Michelle Neben Wittich, MD, Samir H. Patel, MD, Robert L. Foote, MD, Daniel M. Ma, MD, Alex A. Nagelschneider, MD, David M. Routman, MD
Publikováno v:
Advances in Radiation Oncology, Vol 7, Iss 4, Pp 100926- (2022)
Purpose: Human papillomavirus–associated oropharyngeal squamous cell carcinoma (HPV[+]OPSCC) requires further study to optimize the existing clinical staging system and guide treatment selection. We hypothesize that incorporation of the number of r
Externí odkaz:
https://doaj.org/article/a940f1c8ede3433dbf3bc725aa815a6b
Autor:
David B Sauer, Noah Trebesch, Jennifer J Marden, Nicolette Cocco, Jinmei Song, Akiko Koide, Shohei Koide, Emad Tajkhorshid, Da-Neng Wang
Publikováno v:
eLife, Vol 9 (2020)
Citrate, α-ketoglutarate and succinate are TCA cycle intermediates that also play essential roles in metabolic signaling and cellular regulation. These di- and tricarboxylates are imported into the cell by the divalent anion sodium symporter (DASS)
Externí odkaz:
https://doaj.org/article/539d34b7a7c747f68b846074d27714c4
Autor:
Dante J. Merlino, Caitlin J. Vander Wert, Adam B. Sauer, Linda X. Yin, Eric J. Moore, Jonathan M. Morris, Kathryn M. Van Abel
Publikováno v:
Operative Techniques in Otolaryngology-Head and Neck Surgery. 33:272-280
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0126956518a89d4bb88b686e5d838a30
https://doi.org/10.1016/j.otot.2022.10.007
https://doi.org/10.1016/j.otot.2022.10.007
Autor:
Huanyu Z. Li, Ashley C.W. Pike, Gamma Chi, Jesper S. Hansen, Sarah G. Lee, Karin E.J. Rödström, Simon R. Bushell, David Speedman, Adam Evans, Dong Wang, Didi He, Leela Shrestha, Chady Nasrallah, Nicola A. Burgess-Brown, Timothy R. Dafforn, Elisabeth P. Carpenter, David B. Sauer
Proline is widely known as the only proteogenic amino acid with a secondary amine. In addition to its crucial role in protein structure, the secondary amino acid modulates neurotransmission and regulates the kinetics of signaling proteins. To underst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dd0b3c1551d3725c4f410b48f6a6e46
https://doi.org/10.1101/2023.05.17.541173
https://doi.org/10.1101/2023.05.17.541173
Akademický článek
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Autor:
Douglas N. Brawley, David B. Sauer, Jianping Li, Xuhui Zheng, Akiko Koide, Ganesh S. Jedhe, Tiffany Suwatthee, Jinmei Song, Zheng Liu, Paramjit S. Arora, Shohei Koide, Victor J. Torres, Da-Neng Wang, Nathaniel J. Traaseth
Publikováno v:
Nature Chemical Biology. 18:706-712
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1db806ee90dc70d50dd3d48cdf5c98e2
https://doi.org/10.1038/s41589-022-00994-9
https://doi.org/10.1038/s41589-022-00994-9